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• W2889677551 startingPage "2772" @default.
• W2889677551 abstract "By manipulating the various physicochemical properties of amino acids, the design of peptides with specific self-assembling properties has been emerging for more than a decade. In this context, short peptides possessing detergent properties (so-called “peptergents”) have been developed to self-assemble into well-ordered nanostructures that can stabilize membrane proteins for crystallization. In this study, the peptide with “peptergency” properties, called ADA8 and extensively described by Tao et al., is studied by molecular dynamic simulations for its self-assembling properties in different conditions. In water, it spontaneously forms beta sheets with a β barrel-like structure. We next simulated the interaction of this peptide with a membrane protein, the bacteriorhodopsin, in the presence or absence of a micelle of dodecylphosphocholine. According to the literature, the peptergent ADA8 is thought to generate a belt of β structures around the hydrophobic helical domain that could help stabilize purified membrane proteins. Molecular dynamic simulations are here used to image this mechanism and provide further molecular details for the replacement of detergent molecules around the protein. In addition, we generalized this behavior by designing an amphipathic peptide with beta propensity, which was called ABZ12. Both peptides are able to surround the membrane protein and displace surfactant molecules. To our best knowledge, this is the first molecular mechanism proposed for “peptergency”." @default.
• W2889677551 created "2018-09-27" @default.
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• W2889677551 date "2018-09-14" @default.
• W2889677551 modified "2023-10-03" @default.
• W2889677551 title "Insight into the Self-Assembling Properties of Peptergents: A Molecular Dynamics Simulation Study" @default.
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• W2889677551 doi "https://doi.org/10.3390/ijms19092772" @default.
• W2889677551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6163580" @default.
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• W2889677551 hasPublicationYear "2018" @default.
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