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- W2889687588 abstract "Background: Four independent groups have reported de- creased error-related negativity (ERN) amplitude in schizophrenia (Kopp and Rist, 1999; Mathalon et al., 2002; Alain et al., 2002; Bates et al., 2002). Error-related negativity is a response-locked event-related potential (ERP) that reflects activity in the anterior cingulate cortex that is thought to be part of an error detection system (Falkenstein et al., 2000). It has recently been suggested that evoked theta oscillations underlie the ERN (Luu and Tucker, 2001; Luu et al., 2003). This suggests that patients with schizophrenia may be unable to efficiently recruit theta activity during error detection. Methods: We performed power spectrum and wavelet analyses on EEG/ERP data collected during performance of a visual go/no- go task designed to elicit errors in 21 patients with schizophrenia and 21 healthy people. Results: Our findings show that evoked delta and theta oscillations are not coordinated effectively in schizophrenia during error detection. Conversely, there is evidence that in a resting state, patients with schizophrenia show increased slow-wave (delta and theta) activity (Fehr et al., 2003). Conclusion: Perhaps pathological slow-wave activity during resting states inhibits efficient recruitment of slow oscillations for specific functions." @default.
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- W2889687588 date "2004-01-01" @default.
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- W2889687588 title "Inefficient coordination of slow oscillations in schizophrenia" @default.
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