FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889687851> ?p ?o ?g. }

• W2889687851 endingPage "33499" @default.
• W2889687851 startingPage "33482" @default.
• W2889687851 abstract "Double-hit lymphoma (DHL) is a high-grade B-cell lymphoma that harbors concurrent MYC and BCL2 or BCL6 rearrangements. Because cases of MYC/BCL6 DHL are uncommon, most reported conclusions have been based on cases of MYC/BCL2 DHL. Lack of experimental MYC/BCL6 DHL models continues to hinder the pathophysiologic and therapeutic investigations of this disorder. We herein describe a novel MYC/BCL6 DHL cell line, designated DH-My6, carrying both the MYC-IGH and BCL6-IGH fusion genes. Interruptions of MYC and BCL6 expressions using short interfering RNAs and chemical inhibitors led to significant attenuation of DH-My6 cell growth. Greater antitumor effects were found when the cells were treated with a combination of MYC and BCL6 inhibitors. Moreover, the PLK1 inhibitor volasertib and the HDAC inhibitor vorinostat synergized strongly when combined with the bromodomain inhibitor JQ1. DH-My6 is a new well-validated MYC/BCL6 DHL cell line that will provide a useful model for studies of the pathogenesis and therapeutics for the less common DHL tumor type. The rationale for approaches targeting both MYC and BCL6, and in combination with PLK1 or HDAC inhibitors for superior suppression of the aggressive MYC/BCL6 DHL warrants further in vivo testing in a preclinical model." @default.
• W2889687851 created "2018-09-27" @default.
• W2889687851 creator A5010645468 @default.
• W2889687851 creator A5015079445 @default.
• W2889687851 creator A5036835585 @default.
• W2889687851 creator A5043908810 @default.
• W2889687851 creator A5050292463 @default.
• W2889687851 creator A5055750088 @default.
• W2889687851 creator A5058133640 @default.
• W2889687851 creator A5077807337 @default.
• W2889687851 creator A5082060300 @default.
• W2889687851 creator A5082495390 @default.
• W2889687851 date "2018-09-11" @default.
• W2889687851 modified "2023-10-18" @default.
• W2889687851 title "Generation and characteristics of a novel “double-hit” high grade B-cell lymphoma cell line DH-My6 with <i>MYC</i>/<i>IGH</i> and <i>BCL6</i>/<i>IGH</i> gene arrangements and potential molecular targeted therapies" @default.
• W2889687851 cites W1828036224 @default.
• W2889687851 cites W1929028280 @default.
• W2889687851 cites W1956719435 @default.
• W2889687851 cites W1968533894 @default.
• W2889687851 cites W1975776530 @default.
• W2889687851 cites W1983370435 @default.
• W2889687851 cites W1988190692 @default.
• W2889687851 cites W1999025078 @default.
• W2889687851 cites W2002395443 @default.
• W2889687851 cites W2004916962 @default.
• W2889687851 cites W2006070956 @default.
• W2889687851 cites W2008305182 @default.
• W2889687851 cites W2018313485 @default.
• W2889687851 cites W2018796139 @default.
• W2889687851 cites W2019135859 @default.
• W2889687851 cites W2037046216 @default.
• W2889687851 cites W2037479635 @default.
• W2889687851 cites W2055643760 @default.
• W2889687851 cites W2056936324 @default.
• W2889687851 cites W2061742404 @default.
• W2889687851 cites W2064223130 @default.
• W2889687851 cites W2070484767 @default.
• W2889687851 cites W2072924356 @default.
• W2889687851 cites W2073966063 @default.
• W2889687851 cites W2083263253 @default.
• W2889687851 cites W2086508416 @default.
• W2889687851 cites W2090714945 @default.
• W2889687851 cites W2096439168 @default.
• W2889687851 cites W2096797981 @default.
• W2889687851 cites W2097561270 @default.
• W2889687851 cites W2097870229 @default.
• W2889687851 cites W2107808656 @default.
• W2889687851 cites W2119661337 @default.
• W2889687851 cites W2119994239 @default.
• W2889687851 cites W2120572492 @default.
• W2889687851 cites W2125833389 @default.
• W2889687851 cites W2140364596 @default.
• W2889687851 cites W2145791257 @default.
• W2889687851 cites W2150916212 @default.
• W2889687851 cites W2150931624 @default.
• W2889687851 cites W2153422981 @default.
• W2889687851 cites W2155791494 @default.
• W2889687851 cites W2167831982 @default.
• W2889687851 cites W2169287961 @default.
• W2889687851 cites W2175416579 @default.
• W2889687851 cites W2216659987 @default.
• W2889687851 cites W2231127685 @default.
• W2889687851 cites W2310716991 @default.
• W2889687851 cites W2347151465 @default.
• W2889687851 cites W2473994771 @default.
• W2889687851 cites W2505733981 @default.
• W2889687851 cites W2554098092 @default.
• W2889687851 cites W2591459241 @default.
• W2889687851 cites W2724550850 @default.
• W2889687851 cites W2753847758 @default.
• W2889687851 cites W2771193451 @default.
• W2889687851 cites W2788380546 @default.
• W2889687851 doi "https://doi.org/10.18632/oncotarget.26060" @default.
• W2889687851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6173362" @default.
• W2889687851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30323893" @default.
• W2889687851 hasPublicationYear "2018" @default.
• W2889687851 type Work @default.
• W2889687851 sameAs 2889687851 @default.
• W2889687851 citedByCount "7" @default.
• W2889687851 countsByYear W28896878512019 @default.
• W2889687851 countsByYear W28896878512020 @default.
• W2889687851 countsByYear W28896878512021 @default.
• W2889687851 countsByYear W28896878512022 @default.
• W2889687851 countsByYear W28896878512023 @default.
• W2889687851 crossrefType "journal-article" @default.
• W2889687851 hasAuthorship W2889687851A5010645468 @default.
• W2889687851 hasAuthorship W2889687851A5015079445 @default.
• W2889687851 hasAuthorship W2889687851A5036835585 @default.
• W2889687851 hasAuthorship W2889687851A5043908810 @default.
• W2889687851 hasAuthorship W2889687851A5050292463 @default.
• W2889687851 hasAuthorship W2889687851A5055750088 @default.
• W2889687851 hasAuthorship W2889687851A5058133640 @default.
• W2889687851 hasAuthorship W2889687851A5077807337 @default.
• W2889687851 hasAuthorship W2889687851A5082060300 @default.
• W2889687851 hasAuthorship W2889687851A5082495390 @default.
• W2889687851 hasBestOaLocation W28896878511 @default.
• W2889687851 hasConcept C104317684 @default.
• W2889687851 hasConcept C159654299 @default.

• next