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• W2889766174 abstract "Montelukast (MK),a cysteinyl leukotriene (CysLT1) receptor antagonist, latterly exhibited a remarkable neuroprotective activity in various neurodegenerative disorders. This study aims to elucidate the neuroprotective effect of MK in rotenone-induced Parkinson's disease(PD) model in rats. Ninety six male rats were split into four groups: vehicle control (0.2 ml/kg/48 h, sc), MK (10 mg/kg/day, ip), rotenone (1.5 mg/kg/48 h, sc.) and rotenone pretreated with MK. Rotenone treatment led to significant reduction in motor functioning and elevation in oxidative stress markers. Additionally, upregulation of p38 mitogen-activated protein kinase (p38 MAPK) and CysLT1 receptor expressions were anchored with enhanced striatal microglial activation generating a severe neuro-inflammatory milieu. Furthermore, an augmentation in p53 expression and cleaved caspases-3 activity increased apoptotic neurodegeneration synchronized with reduction of striatal tyrosine hydroxylase (TH) content. Changes in neuronal morphology was also noted. MK administration significantly mitigated motor impairment and rise in oxidative stress mediators. As well, the anti-inflammatory activity of MK was manifested by hindering the principal controller of inflammatory pathway, nuclear factor-kappa B, followed by its downstream pro-inflammatory cytokines (tumor necrosis factor-alpha and interleukin-1 beta), by attenuating striatal microglial activation and hampering the expression of both p38 MAPK and CysLT1. Moreover, MK revealed a decline in p53 expression with its downstream cleaved caspases-3 which resulted in preservation of striatal TH terminals as verified by increased striatal TH content and improvement in the histopathological changes incited by rotenone. In conclusion, MK endowed neuroprotective effects in rotenone-induced PD animal model via attenuation of microglial cell activation and p38 MAPK expression." @default.
• W2889766174 created "2018-09-27" @default.
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• W2889766174 date "2018-11-01" @default.
• W2889766174 modified "2023-10-17" @default.
• W2889766174 title "Montelukast attenuates rotenone-induced microglial activation/p38 MAPK expression in rats: Possible role of its antioxidant, anti-inflammatory and antiapoptotic effects" @default.
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• W2889766174 cites W1970272398 @default.
• W2889766174 cites W1972364546 @default.
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• W2889766174 cites W1981711965 @default.
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• W2889766174 cites W1982666490 @default.
• W2889766174 cites W1984403162 @default.
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• W2889766174 cites W1999970418 @default.
• W2889766174 cites W2005182420 @default.
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• W2889766174 cites W2008252631 @default.
• W2889766174 cites W2013847035 @default.
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• W2889766174 cites W2028591298 @default.
• W2889766174 cites W2029503022 @default.
• W2889766174 cites W2029637220 @default.
• W2889766174 cites W2031651670 @default.
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• W2889766174 doi "https://doi.org/10.1016/j.taap.2018.09.012" @default.
• W2889766174 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30222980" @default.
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