FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889804921> ?p ?o ?g. }

• W2889804921 endingPage "250" @default.
• W2889804921 startingPage "242" @default.
• W2889804921 abstract "Summary To study glycolysis/glycogenesis‐related genes expression in childhood B‐cell acute lymphoblastic leukaemia (B‐ ALL ), we performed a microarray‐based analysis using published gene expression profiles. We found that SLC 2A5 , which encodes solute carrier family 2 member 5 ( SLC 2A5, previously termed GLUT 5) that facilitates cell fructose uptake, was up‐regulated in Philadelphia chromosome‐positive ALL (Ph+ ALL ). Microarray‐based analyses also suggested that SLC 2A5 expression was significantly down‐regulated in childhood B‐ ALL with t(1;19) or 11q23 mutation. High SLC 2A5 expression was found in patients who had disease recurrence within 3 years, early relapse, shortened complete remission duration and positive minimal residue disease ( MRD ) status after treatment. SLC 2A5 overexpression at both the mRNA and protein level in Ph+ ALL was confirmed in a validation cohort of childhood B‐ ALL . We also validated the correlation of SLC 2A5 expression and MRD status. A mechanistic study using a human Ph+ ALL cell line showed that BCR ‐ ABL 1 kinase might regulate SLC 2A5 expression via MYC . The tyrosine kinase inhibitors ( TKI s) imatinib and dasatinib repressed SLC 2A5 expression and the cell uptake of fructose. Fructose protected the tumour cells from nutrition deficiency and drug‐induced cell death. Overall, our findings showed that SLC 2A5 was up‐regulated in childhood Ph+ ALL . SLC 2A5 expression correlated with childhood B‐ ALL clinical factors, such as MRD status. Given that TKI s could inhibit SLC 2A5 expression, repression of fructose utility after TKI treatment contributes to TKI ‐induced Ph+ ALL cytotoxicity. Targeting SLC 2A5 might be promising in B‐ ALL treatment, especially for Ph+ ALL patients with high SLC 2A5 expression." @default.
• W2889804921 created "2018-09-27" @default.
• W2889804921 creator A5027657713 @default.
• W2889804921 creator A5030283083 @default.
• W2889804921 creator A5040279346 @default.
• W2889804921 creator A5044524874 @default.
• W2889804921 creator A5046418414 @default.
• W2889804921 creator A5060394961 @default.
• W2889804921 creator A5065791654 @default.
• W2889804921 creator A5077666079 @default.
• W2889804921 creator A5083437982 @default.
• W2889804921 creator A5083930709 @default.
• W2889804921 creator A5086559201 @default.
• W2889804921 date "2018-09-11" @default.
• W2889804921 modified "2023-10-18" @default.
• W2889804921 title "<i>SLC2A5</i> overexpression in childhood philadelphia chromosome-positive acute lymphoblastic leukaemia" @default.
• W2889804921 cites W1737014051 @default.
• W2889804921 cites W1971859682 @default.
• W2889804921 cites W1978260286 @default.
• W2889804921 cites W1991870868 @default.
• W2889804921 cites W1994041743 @default.
• W2889804921 cites W2012690941 @default.
• W2889804921 cites W2037233980 @default.
• W2889804921 cites W2054691377 @default.
• W2889804921 cites W2060605982 @default.
• W2889804921 cites W2065815553 @default.
• W2889804921 cites W2105469447 @default.
• W2889804921 cites W2107398329 @default.
• W2889804921 cites W2117725451 @default.
• W2889804921 cites W2121411163 @default.
• W2889804921 cites W2125277492 @default.
• W2889804921 cites W2129898733 @default.
• W2889804921 cites W2130503287 @default.
• W2889804921 cites W2134118606 @default.
• W2889804921 cites W2135840621 @default.
• W2889804921 cites W2138218344 @default.
• W2889804921 cites W2140306503 @default.
• W2889804921 cites W2145678539 @default.
• W2889804921 cites W2154354914 @default.
• W2889804921 cites W2159754384 @default.
• W2889804921 cites W2166830325 @default.
• W2889804921 cites W2169808956 @default.
• W2889804921 cites W2176791592 @default.
• W2889804921 cites W2277930726 @default.
• W2889804921 cites W2395626624 @default.
• W2889804921 cites W2531874824 @default.
• W2889804921 cites W2737285006 @default.
• W2889804921 cites W2790196090 @default.
• W2889804921 cites W4243761960 @default.
• W2889804921 doi "https://doi.org/10.1111/bjh.15580" @default.
• W2889804921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30272826" @default.
• W2889804921 hasPublicationYear "2018" @default.
• W2889804921 type Work @default.
• W2889804921 sameAs 2889804921 @default.
• W2889804921 citedByCount "14" @default.
• W2889804921 countsByYear W28898049212019 @default.
• W2889804921 countsByYear W28898049212020 @default.
• W2889804921 countsByYear W28898049212021 @default.
• W2889804921 countsByYear W28898049212022 @default.
• W2889804921 countsByYear W28898049212023 @default.
• W2889804921 crossrefType "journal-article" @default.
• W2889804921 hasAuthorship W2889804921A5027657713 @default.
• W2889804921 hasAuthorship W2889804921A5030283083 @default.
• W2889804921 hasAuthorship W2889804921A5040279346 @default.
• W2889804921 hasAuthorship W2889804921A5044524874 @default.
• W2889804921 hasAuthorship W2889804921A5046418414 @default.
• W2889804921 hasAuthorship W2889804921A5060394961 @default.
• W2889804921 hasAuthorship W2889804921A5065791654 @default.
• W2889804921 hasAuthorship W2889804921A5077666079 @default.
• W2889804921 hasAuthorship W2889804921A5083437982 @default.
• W2889804921 hasAuthorship W2889804921A5083930709 @default.
• W2889804921 hasAuthorship W2889804921A5086559201 @default.
• W2889804921 hasBestOaLocation W28898049211 @default.
• W2889804921 hasConcept C104317684 @default.
• W2889804921 hasConcept C126322002 @default.
• W2889804921 hasConcept C150194340 @default.
• W2889804921 hasConcept C153911025 @default.
• W2889804921 hasConcept C2777583451 @default.
• W2889804921 hasConcept C2778461978 @default.
• W2889804921 hasConcept C2778729363 @default.
• W2889804921 hasConcept C2779536868 @default.
• W2889804921 hasConcept C2781107101 @default.
• W2889804921 hasConcept C2909962599 @default.
• W2889804921 hasConcept C42362537 @default.
• W2889804921 hasConcept C502942594 @default.
• W2889804921 hasConcept C54355233 @default.
• W2889804921 hasConcept C62478195 @default.
• W2889804921 hasConcept C71924100 @default.
• W2889804921 hasConcept C8415881 @default.
• W2889804921 hasConcept C86803240 @default.
• W2889804921 hasConceptScore W2889804921C104317684 @default.
• W2889804921 hasConceptScore W2889804921C126322002 @default.
• W2889804921 hasConceptScore W2889804921C150194340 @default.
• W2889804921 hasConceptScore W2889804921C153911025 @default.
• W2889804921 hasConceptScore W2889804921C2777583451 @default.
• W2889804921 hasConceptScore W2889804921C2778461978 @default.
• W2889804921 hasConceptScore W2889804921C2778729363 @default.
• W2889804921 hasConceptScore W2889804921C2779536868 @default.

• next