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• W2889862113 abstract "Substantial cancer genome sequencing efforts have discovered many important driver genes contributing to tumorigenesis. However, very little is known about the genetic alterations of long non‐coding RNA s (lnc RNA s) in cancer. Thus, there is a need for systematic surveys of driver lnc RNA s. Through integrative analysis of 5918 tumors across 11 cancer types, we revealed that lnc RNA s have undergone dramatic genomic alterations, many of which are mutually exclusive with well‐known cancer genes. Using the hypothesis of functional redundancy of mutual exclusivity, we developed a computational framework to identify driver lnc RNA s associated with different cancer hallmarks. Applying it to pan‐cancer data, we identified 378 candidate driver lnc RNA s whose genomic features highly resemble the known cancer driver genes (e.g. high conservation and early replication). We further validated the candidate driver lnc RNA s involved in ‘Tissue Invasion and Metastasis’ in lung adenocarcinoma and breast cancer, and also highlighted their potential roles in improving clinical outcomes. In summary, we have generated a comprehensive landscape of cancer candidate driver lnc RNA s that could act as a starting point for future functional explorations, as well as the identification of biomarkers and lnc RNA ‐based target therapy." @default.
• W2889862113 created "2018-09-27" @default.
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• W2889862113 date "2018-10-02" @default.
• W2889862113 modified "2023-10-06" @default.
• W2889862113 title "A pan‐cancer atlas of cancer hallmark‐associated candidate driver lnc <scp>RNA</scp> s" @default.
• W2889862113 cites W1771334570 @default.
• W2889862113 cites W1844327812 @default.
• W2889862113 cites W1892182006 @default.
• W2889862113 cites W1956871134 @default.
• W2889862113 cites W1957438118 @default.
• W2889862113 cites W1973675115 @default.
• W2889862113 cites W1977572305 @default.
• W2889862113 cites W1978944350 @default.
• W2889862113 cites W1987853946 @default.
• W2889862113 cites W1990347487 @default.
• W2889862113 cites W2004382890 @default.
• W2889862113 cites W2004966039 @default.
• W2889862113 cites W2008033547 @default.
• W2889862113 cites W2009720434 @default.
• W2889862113 cites W2013335792 @default.
• W2889862113 cites W2016661249 @default.
• W2889862113 cites W2027533075 @default.
• W2889862113 cites W2029919331 @default.
• W2889862113 cites W2031167624 @default.
• W2889862113 cites W2033073810 @default.
• W2889862113 cites W2033666853 @default.
• W2889862113 cites W2034269086 @default.
• W2889862113 cites W2035189255 @default.
• W2889862113 cites W2039877945 @default.
• W2889862113 cites W2042851051 @default.
• W2889862113 cites W2043398720 @default.
• W2889862113 cites W2044433401 @default.
• W2889862113 cites W2067768332 @default.
• W2889862113 cites W2088325873 @default.
• W2889862113 cites W2088544963 @default.
• W2889862113 cites W2089855871 @default.
• W2889862113 cites W2093158628 @default.
• W2889862113 cites W2096465161 @default.
• W2889862113 cites W2097065948 @default.
• W2889862113 cites W2097113581 @default.
• W2889862113 cites W2102140136 @default.
• W2889862113 cites W2105924489 @default.
• W2889862113 cites W2112012611 @default.
• W2889862113 cites W2113868616 @default.
• W2889862113 cites W2114104545 @default.
• W2889862113 cites W2114342401 @default.
• W2889862113 cites W2114843025 @default.
• W2889862113 cites W2116798163 @default.
• W2889862113 cites W2117307067 @default.
• W2889862113 cites W2117396697 @default.
• W2889862113 cites W2117692326 @default.
• W2889862113 cites W2124996418 @default.
• W2889862113 cites W2130925862 @default.
• W2889862113 cites W2133809584 @default.
• W2889862113 cites W2137526110 @default.
• W2889862113 cites W2137724360 @default.
• W2889862113 cites W2141811925 @default.
• W2889862113 cites W2144940507 @default.
• W2889862113 cites W2145191876 @default.
• W2889862113 cites W2146512944 @default.
• W2889862113 cites W2147900600 @default.
• W2889862113 cites W2147985894 @default.
• W2889862113 cites W2148883613 @default.
• W2889862113 cites W2149082178 @default.
• W2889862113 cites W2149441684 @default.
• W2889862113 cites W2150836292 @default.
• W2889862113 cites W2157852151 @default.
• W2889862113 cites W2159380507 @default.
• W2889862113 cites W2162547088 @default.
• W2889862113 cites W2167230556 @default.
• W2889862113 cites W2168303063 @default.
• W2889862113 cites W2170000375 @default.
• W2889862113 cites W2172896922 @default.
• W2889862113 cites W2174049393 @default.
• W2889862113 cites W2216283224 @default.
• W2889862113 cites W2231690112 @default.
• W2889862113 cites W2259938310 @default.
• W2889862113 cites W2262212683 @default.
• W2889862113 cites W2262414037 @default.
• W2889862113 cites W2269199783 @default.
• W2889862113 cites W2293799788 @default.
• W2889862113 cites W2295971206 @default.
• W2889862113 cites W2302541819 @default.
• W2889862113 cites W2311921258 @default.
• W2889862113 cites W2327590178 @default.

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