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- W2889870564 abstract "We investigate the potential association between leucine-rich repeat kinase 2 (LRRK2) mutations and voice. Sustained phonations (‘aaah’ sounds) were recorded from 7 individuals with LRRK2-associated Parkinson’s disease (PD), 17 participants with idiopathic PD (iPD), 20 non-manifesting LRRK2-mutatio n carriers, 25 related non-carriers, and 26 controls. In distinguishing LRRK2-associated PD and iPD, the mean sensitivity was 95.4% (SD 17.8%) and mean specificity was 89.6% (SD 26.5%). Voice features for non-manifesting carriers, related non-carriers, and controls were much less discriminatory. Vocal deficits in LRRK2-associated PD may be different than those in iPD. These preliminary results warrant longitudinal analyses and replication in larger cohorts." @default.
- W2889870564 created "2018-09-27" @default.
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- W2889870564 date "2018-10-17" @default.
- W2889870564 modified "2023-09-29" @default.
- W2889870564 title "Investigating Voice as a Biomarker for Leucine-Rich Repeat Kinase 2-Associated Parkinson’s Disease" @default.
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- W2889870564 doi "https://doi.org/10.3233/jpd-181389" @default.
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