Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889877109> ?p ?o ?g. }
- W2889877109 abstract "The standard model of multiple myeloma (MM) oncogenesis is based on the genetic instability of MM cells and presents its evolution as the emergence of clones with more and more aggressive genotypes, giving them surviving and proliferating advantage. The micro-environment has a passive role. In contrast, many works have shown that the progression of MM is also characterized by the selection of clones with extended phenotypes able to destroy bone trabeculae, suggesting a major role for early micro-environmental disruption. We present a model of MM oncogenesis in which genetic instability is the consequence of the disruption of normal interactions between plasma cells and their environment, the bone remodeling compartment. These interactions, which normally ensure the stability of the genotypes and phenotypes of normal plasma cells could be disrupted by many factors as soon as the early steps of the disease (MGUS, pre-MGUS states). Therapeutical implications of the model are presented." @default.
- W2889877109 created "2018-09-27" @default.
- W2889877109 creator A5072235870 @default.
- W2889877109 creator A5074449943 @default.
- W2889877109 date "2018-09-10" @default.
- W2889877109 modified "2023-10-15" @default.
- W2889877109 title "Multiple Myeloma Exemplifies a Model of Cancer Based on Tissue Disruption as the Initiator Event" @default.
- W2889877109 cites W1484498617 @default.
- W2889877109 cites W1484502710 @default.
- W2889877109 cites W1609171779 @default.
- W2889877109 cites W1685814017 @default.
- W2889877109 cites W1783306815 @default.
- W2889877109 cites W1912299294 @default.
- W2889877109 cites W1920131111 @default.
- W2889877109 cites W1933867057 @default.
- W2889877109 cites W1956871134 @default.
- W2889877109 cites W1968121313 @default.
- W2889877109 cites W1973328408 @default.
- W2889877109 cites W1979104000 @default.
- W2889877109 cites W1985365629 @default.
- W2889877109 cites W1988170766 @default.
- W2889877109 cites W1989257040 @default.
- W2889877109 cites W1989343687 @default.
- W2889877109 cites W1990522010 @default.
- W2889877109 cites W1995573845 @default.
- W2889877109 cites W1997324903 @default.
- W2889877109 cites W2014051864 @default.
- W2889877109 cites W2014053946 @default.
- W2889877109 cites W2014434727 @default.
- W2889877109 cites W2014887548 @default.
- W2889877109 cites W2017614316 @default.
- W2889877109 cites W2020846591 @default.
- W2889877109 cites W2024234501 @default.
- W2889877109 cites W2025391134 @default.
- W2889877109 cites W2027280031 @default.
- W2889877109 cites W2030525152 @default.
- W2889877109 cites W2035238501 @default.
- W2889877109 cites W2036986058 @default.
- W2889877109 cites W2047794102 @default.
- W2889877109 cites W2056265113 @default.
- W2889877109 cites W2058555823 @default.
- W2889877109 cites W2066758340 @default.
- W2889877109 cites W2068578858 @default.
- W2889877109 cites W2070114538 @default.
- W2889877109 cites W2070323900 @default.
- W2889877109 cites W2072066100 @default.
- W2889877109 cites W2074784947 @default.
- W2889877109 cites W2087485599 @default.
- W2889877109 cites W2089608956 @default.
- W2889877109 cites W2093049840 @default.
- W2889877109 cites W2095491090 @default.
- W2889877109 cites W2096127904 @default.
- W2889877109 cites W2104958967 @default.
- W2889877109 cites W2111159843 @default.
- W2889877109 cites W2112598631 @default.
- W2889877109 cites W2114409684 @default.
- W2889877109 cites W2124911327 @default.
- W2889877109 cites W2125734502 @default.
- W2889877109 cites W2126369996 @default.
- W2889877109 cites W2130419960 @default.
- W2889877109 cites W2136683669 @default.
- W2889877109 cites W2137318638 @default.
- W2889877109 cites W2146118002 @default.
- W2889877109 cites W2146994105 @default.
- W2889877109 cites W2148417840 @default.
- W2889877109 cites W2157155777 @default.
- W2889877109 cites W2164174012 @default.
- W2889877109 cites W2168221215 @default.
- W2889877109 cites W2178975387 @default.
- W2889877109 cites W2194404144 @default.
- W2889877109 cites W2204695746 @default.
- W2889877109 cites W2260034029 @default.
- W2889877109 cites W2263219150 @default.
- W2889877109 cites W2270513992 @default.
- W2889877109 cites W2331840806 @default.
- W2889877109 cites W2335662053 @default.
- W2889877109 cites W2341474791 @default.
- W2889877109 cites W2346990949 @default.
- W2889877109 cites W2511571730 @default.
- W2889877109 cites W2529884397 @default.
- W2889877109 cites W2531485251 @default.
- W2889877109 cites W2551754010 @default.
- W2889877109 cites W2570629027 @default.
- W2889877109 cites W2570693521 @default.
- W2889877109 cites W2591058932 @default.
- W2889877109 cites W2737272162 @default.
- W2889877109 cites W2741486044 @default.
- W2889877109 cites W2744373774 @default.
- W2889877109 cites W2752074361 @default.
- W2889877109 cites W2755640313 @default.
- W2889877109 cites W2767028732 @default.
- W2889877109 cites W2803031230 @default.
- W2889877109 cites W2950647373 @default.
- W2889877109 cites W4211058750 @default.
- W2889877109 cites W784052289 @default.
- W2889877109 cites W164752069 @default.
- W2889877109 doi "https://doi.org/10.3389/fonc.2018.00355" @default.
- W2889877109 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6140628" @default.
- W2889877109 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30250824" @default.
- W2889877109 hasPublicationYear "2018" @default.