FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889878770> ?p ?o ?g. }

• W2889878770 endingPage "293" @default.
• W2889878770 startingPage "283" @default.
• W2889878770 abstract "Nanomedicines for controlled drug release provide temporal and spatial regulation of drug bioavailability in the body. The timing of drug release is usually engineered either for slow gradual release over an extended period of time or for rapid release triggered by a specific change in its physicochemical environment. However, between these two extremes, there is the desirable possibility of adaptive nanomedicines that dynamically modulate drug release in tune with its changing environment. Adaptation and response through communication with its environment is a fundamental trait of living systems; therefore, the design of biomimetic nanomedicines through the approaches of bottom-up synthetic biology provides a viable route to this goal. This could enable drug delivery systems to optimize release in synchronicity with the body’s natural biological rhythms and the personalized physiological characteristics of the patient, e.g. their metabolic rate. Living systems achieve this responsiveness through feedback-controlled biochemical processes that regulate their functional outputs. Towards this goal of adaptive drug delivery systems, we review the general benefits of nanomedicine formulations, provide existing examples of experimental nanomedicines that encapsulate the metabolic function of enzymes, and give relevant examples of feedback-controlled chemical systems. These are the underpinning concepts that hold promise to be combined to form novel adaptive release systems. Furthermore, we motivate the advantages of adaptive release through chronobiological examples. By providing a brief review of these topics and an assessment of the state of the art, we aim to provide a useful resource to accelerate developments in this field. Impact statement The timing and rate of release of pharmaceuticals from advanced drug delivery systems is an important property that has received considerable attention in the scientific literature. Broadly, these mostly fall into two classes: controlled release with a prolonged release rate or triggered release where the drug is rapidly released in response to an environmental stimulus. This review aims to highlight the potential for developing adaptive release systems that more subtlety modulate the drug release profile through continuous communication with its environment facilitated through feedback control. By reviewing the key elements of this approach in one place (fundamental principles of nanomedicine, enzymatic nanoreactors for medical therapies and feedback-controlled chemical systems) and providing additional motivating case studies in the context of chronobiology, we hope to inspire innovative development of novel “chrononanomedicines.”" @default.
• W2889878770 created "2018-09-27" @default.
• W2889878770 creator A5036800703 @default.
• W2889878770 creator A5043727730 @default.
• W2889878770 creator A5084025033 @default.
• W2889878770 date "2018-09-11" @default.
• W2889878770 modified "2023-10-16" @default.
• W2889878770 title "Towards feedback-controlled nanomedicines for smart, adaptive delivery" @default.
• W2889878770 cites W1615752531 @default.
• W2889878770 cites W1967148095 @default.
• W2889878770 cites W1967921248 @default.
• W2889878770 cites W1968487347 @default.
• W2889878770 cites W1968720341 @default.
• W2889878770 cites W1968940071 @default.
• W2889878770 cites W1976041621 @default.
• W2889878770 cites W1977168590 @default.
• W2889878770 cites W1977688569 @default.
• W2889878770 cites W1979333743 @default.
• W2889878770 cites W1980923443 @default.
• W2889878770 cites W1982576308 @default.
• W2889878770 cites W1983345272 @default.
• W2889878770 cites W1984207232 @default.
• W2889878770 cites W1989230986 @default.
• W2889878770 cites W1990016432 @default.
• W2889878770 cites W1992533252 @default.
• W2889878770 cites W1992865052 @default.
• W2889878770 cites W1995185717 @default.
• W2889878770 cites W1998318331 @default.
• W2889878770 cites W2001316795 @default.
• W2889878770 cites W2003302378 @default.
• W2889878770 cites W2005693445 @default.
• W2889878770 cites W2005761035 @default.
• W2889878770 cites W2007344686 @default.
• W2889878770 cites W2007382692 @default.
• W2889878770 cites W2008536525 @default.
• W2889878770 cites W2009400453 @default.
• W2889878770 cites W2009444873 @default.
• W2889878770 cites W2010008279 @default.
• W2889878770 cites W2012440525 @default.
• W2889878770 cites W2013765163 @default.
• W2889878770 cites W2015712188 @default.
• W2889878770 cites W2024663449 @default.
• W2889878770 cites W2024738831 @default.
• W2889878770 cites W2026455198 @default.
• W2889878770 cites W2030945597 @default.
• W2889878770 cites W2031183376 @default.
• W2889878770 cites W2032760352 @default.
• W2889878770 cites W2033736907 @default.
• W2889878770 cites W2036904104 @default.
• W2889878770 cites W2038307452 @default.
• W2889878770 cites W2039910311 @default.
• W2889878770 cites W2040430641 @default.
• W2889878770 cites W2043844582 @default.
• W2889878770 cites W2047681925 @default.
• W2889878770 cites W2047997534 @default.
• W2889878770 cites W2048829256 @default.
• W2889878770 cites W2050140383 @default.
• W2889878770 cites W2052831989 @default.
• W2889878770 cites W2053019592 @default.
• W2889878770 cites W2057119480 @default.
• W2889878770 cites W2058465502 @default.
• W2889878770 cites W2060614446 @default.
• W2889878770 cites W2061498410 @default.
• W2889878770 cites W2061772705 @default.
• W2889878770 cites W2064390452 @default.
• W2889878770 cites W2070445081 @default.
• W2889878770 cites W2070802265 @default.
• W2889878770 cites W2071636590 @default.
• W2889878770 cites W2073432826 @default.
• W2889878770 cites W2077023123 @default.
• W2889878770 cites W2079258400 @default.
• W2889878770 cites W2081208715 @default.
• W2889878770 cites W2083651852 @default.
• W2889878770 cites W2084596253 @default.
• W2889878770 cites W2087372079 @default.
• W2889878770 cites W2088407563 @default.
• W2889878770 cites W2093065590 @default.
• W2889878770 cites W2094608596 @default.
• W2889878770 cites W2099376929 @default.
• W2889878770 cites W2099787805 @default.
• W2889878770 cites W2101275678 @default.
• W2889878770 cites W2102449174 @default.
• W2889878770 cites W2105517087 @default.
• W2889878770 cites W2106362845 @default.
• W2889878770 cites W2107660675 @default.
• W2889878770 cites W2108605961 @default.
• W2889878770 cites W2109239812 @default.
• W2889878770 cites W2111261780 @default.
• W2889878770 cites W2111403841 @default.
• W2889878770 cites W2113999268 @default.
• W2889878770 cites W2114597423 @default.
• W2889878770 cites W2115752416 @default.
• W2889878770 cites W2116067233 @default.
• W2889878770 cites W2120983965 @default.
• W2889878770 cites W2122414822 @default.
• W2889878770 cites W2126600254 @default.
• W2889878770 cites W2130166533 @default.
• W2889878770 cites W2132859930 @default.

• next