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• W2889890338 abstract "Abstract Objective The prognostic value of cerebrospinal fluid neurofilament light chain, total tau, phosphorylated tau 181 , and amyloid beta 1‐42 was examined in frontotemporal dementia subtypes. Methods We compared baseline biomarkers between 49 controls, 40 patients with behavioral variant frontotemporal dementia, 24 with semantic variant primary progressive aphasia, and 26 with nonfluent variant primary progressive aphasia. Linear mixed effect models were used to assess the value of baseline biomarkers in predicting clinical and radiographic change in patient cohorts over multiple yearly follow up visits. Results Neurofilament light chain concentrations were lowest in controls. Elevated baseline neurofilament light chain predicted faster worsening in clinical severity, frontotemporal volume and frontotemporal fractional anisotropy in patients with behavioral variant frontotemporal dementia and nonfluent variant primary progressive aphasia. High total tau similarly predicted faster progression in nonfluent variant primary progressive aphasia. In behavioral variant frontotemporal dementia, higher phosphorylated tau 181 predicted faster clinical progression whereas lower amyloid beta 1‐42 predicted faster volumetric and fractional anisotropy reduction. Neurofilament light chain and phosphorylated tau 181 were of greater predictive value in patients with tau pathology as compared to TDP ‐43 pathology. Baseline neurofilament light chain correlated with baseline clinical severity and frontotemporal volume in behavioral variant frontotemporal dementia. Baseline total tau correlated with baseline clinical severity in semantic variant primary progressive aphasia. Interpretation High cerebrospinal fluid neurofilament light chain predicts more aggressive disease in behavioral variant frontotemporal dementia and nonfluent variant primary progressive aphasia. Total tau, phosphorylated tau 181 , and amyloid beta 1‐42 also predict some measures of disease aggressiveness in frontotemporal dementia." @default.
• W2889890338 created "2018-09-27" @default.
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• W2889890338 date "2018-09-20" @default.
• W2889890338 modified "2023-10-16" @default.
• W2889890338 title "Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory" @default.
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• W2889890338 doi "https://doi.org/10.1002/acn3.643" @default.
• W2889890338 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6186942" @default.
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• W2889890338 hasPublicationYear "2018" @default.
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