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• W2889898520 abstract "Rod-shaped mycobacteria expand from their poles, yet d-amino acid probes label cell wall peptidoglycan in this genus at both the poles and sidewall. We sought to clarify the metabolic fates of these probes. Monopeptide incorporation was decreased by antibiotics that block peptidoglycan synthesis or l,d-transpeptidation and in an l,d-transpeptidase mutant. Dipeptides complemented defects in d-alanine synthesis or ligation and were present in lipid-linked peptidoglycan precursors. Characterizing probe uptake pathways allowed us to localize peptidoglycan metabolism with precision: monopeptide-marked l,d-transpeptidase remodeling and dipeptide-marked synthesis were coincident with mycomembrane metabolism at the poles, septum and sidewall. Fluorescent pencillin-marked d,d-transpeptidation around the cell perimeter further suggested that the mycobacterial sidewall is a site of cell wall assembly. While polar peptidoglycan synthesis was associated with cell elongation, sidewall synthesis responded to cell wall damage. Peptidoglycan editing along the sidewall may support cell wall robustness in pole-growing mycobacteria." @default.
• W2889898520 created "2018-09-27" @default.
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• W2889898520 date "2018-09-10" @default.
• W2889898520 modified "2023-10-10" @default.
• W2889898520 title "Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria" @default.
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• W2889898520 doi "https://doi.org/10.7554/elife.37243" @default.
• W2889898520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6191288" @default.
• W2889898520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30198841" @default.
• W2889898520 hasPublicationYear "2018" @default.
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