FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889921316> ?p ?o ?g. }

• W2889921316 endingPage "312" @default.
• W2889921316 startingPage "303" @default.
• W2889921316 abstract "Mitochondria are metabolic organelles that are essential for mammalian life, but the dynamics of mitochondrial metabolism within mammalian tissues in vivo remains incompletely understood. While whole-tissue metabolite profiling has been useful for studying metabolism in vivo, such an approach lacks resolution at the cellular and subcellular level. In vivo methods for interrogating organellar metabolites in specific cell types within mammalian tissues have been limited. To address this, we built on prior work in which we exploited a mitochondrially localized 3XHA epitope tag (MITO-Tag) for the fast isolation of mitochondria from cultured cells to generate MITO-Tag Mice. Affording spatiotemporal control over MITO-Tag expression, these transgenic animals enable the rapid, cell-type-specific immunoisolation of mitochondria from tissues, which we verified using a combination of proteomic and metabolomic approaches. Using MITO-Tag Mice and targeted and untargeted metabolite profiling, we identified changes during fasted and refed conditions in a diverse array of mitochondrial metabolites in hepatocytes and found metabolites that behaved differently at the mitochondrial versus whole-tissue level. MITO-Tag Mice should have utility for studying mitochondrial physiology, and our strategy should be generally applicable for studying other mammalian organelles in specific cell types in vivo." @default.
• W2889921316 created "2018-09-27" @default.
• W2889921316 creator A5013013308 @default.
• W2889921316 creator A5013036635 @default.
• W2889921316 creator A5013582936 @default.
• W2889921316 creator A5020220514 @default.
• W2889921316 creator A5029795445 @default.
• W2889921316 creator A5041351477 @default.
• W2889921316 creator A5043439701 @default.
• W2889921316 creator A5043976055 @default.
• W2889921316 creator A5045437960 @default.
• W2889921316 creator A5072729553 @default.
• W2889921316 creator A5083891173 @default.
• W2889921316 date "2018-12-12" @default.
• W2889921316 modified "2023-10-15" @default.
• W2889921316 title "MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo" @default.
• W2889921316 cites W1503760388 @default.
• W2889921316 cites W1568300712 @default.
• W2889921316 cites W1982555544 @default.
• W2889921316 cites W1987064503 @default.
• W2889921316 cites W1994873852 @default.
• W2889921316 cites W1995856733 @default.
• W2889921316 cites W2004148053 @default.
• W2889921316 cites W2009885573 @default.
• W2889921316 cites W2012966224 @default.
• W2889921316 cites W2017455861 @default.
• W2889921316 cites W2019370546 @default.
• W2889921316 cites W2043866373 @default.
• W2889921316 cites W2048633779 @default.
• W2889921316 cites W2067822001 @default.
• W2889921316 cites W2069860553 @default.
• W2889921316 cites W2094244157 @default.
• W2889921316 cites W2104696999 @default.
• W2889921316 cites W2122091775 @default.
• W2889921316 cites W2150626351 @default.
• W2889921316 cites W2154194922 @default.
• W2889921316 cites W2180760460 @default.
• W2889921316 cites W2465187827 @default.
• W2889921316 cites W2517861725 @default.
• W2889921316 cites W2562858475 @default.
• W2889921316 cites W2607778027 @default.
• W2889921316 cites W2758922213 @default.
• W2889921316 cites W2765934351 @default.
• W2889921316 cites W2766243612 @default.
• W2889921316 cites W2791400496 @default.
• W2889921316 cites W2794361030 @default.
• W2889921316 cites W2802593879 @default.
• W2889921316 cites W2889104191 @default.
• W2889921316 cites W4256316091 @default.
• W2889921316 cites W94071454 @default.
• W2889921316 doi "https://doi.org/10.1073/pnas.1816656115" @default.
• W2889921316 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6320505" @default.
• W2889921316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30541894" @default.
• W2889921316 hasPublicationYear "2018" @default.
• W2889921316 type Work @default.
• W2889921316 sameAs 2889921316 @default.
• W2889921316 citedByCount "73" @default.
• W2889921316 countsByYear W28899213162018 @default.
• W2889921316 countsByYear W28899213162019 @default.
• W2889921316 countsByYear W28899213162020 @default.
• W2889921316 countsByYear W28899213162021 @default.
• W2889921316 countsByYear W28899213162022 @default.
• W2889921316 countsByYear W28899213162023 @default.
• W2889921316 crossrefType "journal-article" @default.
• W2889921316 hasAuthorship W2889921316A5013013308 @default.
• W2889921316 hasAuthorship W2889921316A5013036635 @default.
• W2889921316 hasAuthorship W2889921316A5013582936 @default.
• W2889921316 hasAuthorship W2889921316A5020220514 @default.
• W2889921316 hasAuthorship W2889921316A5029795445 @default.
• W2889921316 hasAuthorship W2889921316A5041351477 @default.
• W2889921316 hasAuthorship W2889921316A5043439701 @default.
• W2889921316 hasAuthorship W2889921316A5043976055 @default.
• W2889921316 hasAuthorship W2889921316A5045437960 @default.
• W2889921316 hasAuthorship W2889921316A5072729553 @default.
• W2889921316 hasAuthorship W2889921316A5083891173 @default.
• W2889921316 hasBestOaLocation W28899213161 @default.
• W2889921316 hasConcept C104317684 @default.
• W2889921316 hasConcept C1491633281 @default.
• W2889921316 hasConcept C168240541 @default.
• W2889921316 hasConcept C189014844 @default.
• W2889921316 hasConcept C207001950 @default.
• W2889921316 hasConcept C21565614 @default.
• W2889921316 hasConcept C2777477808 @default.
• W2889921316 hasConcept C28859421 @default.
• W2889921316 hasConcept C46111723 @default.
• W2889921316 hasConcept C54355233 @default.
• W2889921316 hasConcept C55493867 @default.
• W2889921316 hasConcept C60644358 @default.
• W2889921316 hasConcept C70721500 @default.
• W2889921316 hasConcept C86803240 @default.
• W2889921316 hasConcept C95444343 @default.
• W2889921316 hasConceptScore W2889921316C104317684 @default.
• W2889921316 hasConceptScore W2889921316C1491633281 @default.
• W2889921316 hasConceptScore W2889921316C168240541 @default.
• W2889921316 hasConceptScore W2889921316C189014844 @default.
• W2889921316 hasConceptScore W2889921316C207001950 @default.
• W2889921316 hasConceptScore W2889921316C21565614 @default.
• W2889921316 hasConceptScore W2889921316C2777477808 @default.

• next