FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889921543> ?p ?o ?g. }

• W2889921543 abstract "Pathogenic Gram-negative bacteria interact with their eukaryotic hosts by deploying the type III translocon to inject effector proteins into the cytosol of eukaryotic cells. The translocon compositions, the number and biochemical characteristics of type III translocators in animal-pathogenic bacteria have been well elucidated, but information is lacking for plant-pathogenic bacteria. With extensive studies on biological functions of the Hpa1 protein secreted by the type III secretion system in Xanthomonas oryzae pv. oryzae (Xoo), we show here that Hpa1 is a type III translocator based on measurements of two proteins categorized as transcription activator-like (TAL) effector. Hpa1 was functionally associated with the TAL effector PthXo1 or AvrXa10 by genetic analysis of the wild-type Xoo strain and related mutants or recombinant strains. Inoculation experiments suggested that Hpa1 is required not only for the virulent role of PthXo1 in the susceptible rice variety Nipponbare, but also for the avirulent function of AvrXa10 on the resistant rice variety IRBB10. Hpa1 is unrelated to the secretion of PthXo1 and AvrXa10 out of bacterial cells. However, Hpa1 is critical for both TAL effectors to be translocated from bacterial cells into the cytosol of rice cells based on replicate experiments performed on the susceptible and resistant varieties, respectively. Hpa1-mediated translocation of PthXo1 is coincident with induced expression of rice SWEET11 gene, which is the regulatory target of PthXo1, resulting in the occurrence of the bacterial blight disease in the susceptible rice variety. By contrast, the immune hypersensitive response is induced in agreement with induced expression of rice Xa10 gene, which is the target of AvrXa10, only when AvrXa10 is translocated from bacteria into cells of the resistant rice variety. All the virulent or avirulent performances of the TAL effectors are nullified by directed mutation that removes the α-helix motif from the Hpa1 sequence. The genetic and biochemical data demonstrate that Hap1 is a type III translocator at least for TAL effectors PthXo1 and AvrXa10. The effect of the directed mutation suggests that Hpa1 depends on its α-helical motif to fulfil the translocator function." @default.
• W2889921543 created "2018-09-27" @default.
• W2889921543 creator A5007348590 @default.
• W2889921543 creator A5039734501 @default.
• W2889921543 creator A5070044389 @default.
• W2889921543 creator A5071951038 @default.
• W2889921543 creator A5075659421 @default.
• W2889921543 creator A5082815416 @default.
• W2889921543 creator A5088380856 @default.
• W2889921543 date "2018-09-04" @default.
• W2889921543 modified "2023-10-18" @default.
• W2889921543 title "Hpa1 is a type III translocator in Xanthomonas oryzae pv. oryzae" @default.
• W2889921543 cites W1611159429 @default.
• W2889921543 cites W1909012166 @default.
• W2889921543 cites W1965379264 @default.
• W2889921543 cites W1967563710 @default.
• W2889921543 cites W1980079387 @default.
• W2889921543 cites W1999248739 @default.
• W2889921543 cites W2000512457 @default.
• W2889921543 cites W2003265698 @default.
• W2889921543 cites W2006635484 @default.
• W2889921543 cites W2007276966 @default.
• W2889921543 cites W2021743399 @default.
• W2889921543 cites W2035983426 @default.
• W2889921543 cites W2038784347 @default.
• W2889921543 cites W2045372679 @default.
• W2889921543 cites W2048959467 @default.
• W2889921543 cites W2061142784 @default.
• W2889921543 cites W2064077407 @default.
• W2889921543 cites W2067732567 @default.
• W2889921543 cites W2076556358 @default.
• W2889921543 cites W2078508132 @default.
• W2889921543 cites W2081211654 @default.
• W2889921543 cites W2084825382 @default.
• W2889921543 cites W2084879868 @default.
• W2889921543 cites W2088816616 @default.
• W2889921543 cites W2089040112 @default.
• W2889921543 cites W2089502924 @default.
• W2889921543 cites W2095856124 @default.
• W2889921543 cites W2096793632 @default.
• W2889921543 cites W2100700006 @default.
• W2889921543 cites W2100836382 @default.
• W2889921543 cites W2110203890 @default.
• W2889921543 cites W2117956345 @default.
• W2889921543 cites W2119063553 @default.
• W2889921543 cites W2122741036 @default.
• W2889921543 cites W2130723259 @default.
• W2889921543 cites W2130931930 @default.
• W2889921543 cites W2135554057 @default.
• W2889921543 cites W2145163823 @default.
• W2889921543 cites W2168606129 @default.
• W2889921543 cites W2278826620 @default.
• W2889921543 cites W2291367804 @default.
• W2889921543 cites W2314185483 @default.
• W2889921543 cites W2417027072 @default.
• W2889921543 cites W2736504904 @default.
• W2889921543 doi "https://doi.org/10.1186/s12866-018-1251-3" @default.
• W2889921543 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6123991" @default.
• W2889921543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30180793" @default.
• W2889921543 hasPublicationYear "2018" @default.
• W2889921543 type Work @default.
• W2889921543 sameAs 2889921543 @default.
• W2889921543 citedByCount "24" @default.
• W2889921543 countsByYear W28899215432018 @default.
• W2889921543 countsByYear W28899215432019 @default.
• W2889921543 countsByYear W28899215432020 @default.
• W2889921543 countsByYear W28899215432021 @default.
• W2889921543 countsByYear W28899215432022 @default.
• W2889921543 countsByYear W28899215432023 @default.
• W2889921543 crossrefType "journal-article" @default.
• W2889921543 hasAuthorship W2889921543A5007348590 @default.
• W2889921543 hasAuthorship W2889921543A5039734501 @default.
• W2889921543 hasAuthorship W2889921543A5070044389 @default.
• W2889921543 hasAuthorship W2889921543A5071951038 @default.
• W2889921543 hasAuthorship W2889921543A5075659421 @default.
• W2889921543 hasAuthorship W2889921543A5082815416 @default.
• W2889921543 hasAuthorship W2889921543A5088380856 @default.
• W2889921543 hasBestOaLocation W28899215431 @default.
• W2889921543 hasConcept C104317684 @default.
• W2889921543 hasConcept C130211564 @default.
• W2889921543 hasConcept C2776460866 @default.
• W2889921543 hasConcept C2776964914 @default.
• W2889921543 hasConcept C2780746887 @default.
• W2889921543 hasConcept C2780785505 @default.
• W2889921543 hasConcept C49039625 @default.
• W2889921543 hasConcept C51785407 @default.
• W2889921543 hasConcept C523546767 @default.
• W2889921543 hasConcept C54355233 @default.
• W2889921543 hasConcept C55493867 @default.
• W2889921543 hasConcept C60987743 @default.
• W2889921543 hasConcept C86803240 @default.
• W2889921543 hasConcept C89423630 @default.
• W2889921543 hasConcept C95444343 @default.
• W2889921543 hasConceptScore W2889921543C104317684 @default.
• W2889921543 hasConceptScore W2889921543C130211564 @default.
• W2889921543 hasConceptScore W2889921543C2776460866 @default.
• W2889921543 hasConceptScore W2889921543C2776964914 @default.
• W2889921543 hasConceptScore W2889921543C2780746887 @default.
• W2889921543 hasConceptScore W2889921543C2780785505 @default.
• W2889921543 hasConceptScore W2889921543C49039625 @default.

• next