Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889930424> ?p ?o ?g. }
- W2889930424 abstract "Abstract Heat shock induces a conserved transcriptional program regulated by heat shock factor 1 (Hsf1) in eukaryotic cells. Activation of this heat-shock response is triggered by heat-induced misfolding of newly synthesized polypeptides, and so has been thought to depend on ongoing protein synthesis. Here, using the the budding yeast Saccharomyces cerevisiae , we report the discovery that Hsf1 can be robustly activated when protein synthesis is inhibited, so long as cells undergo cytosolic acidification. Heat shock has long been known to cause transient intracellular acidification which, for reasons which have remained unclear, is associated with increased stress resistance in eukaryotes. We demonstrate that acidification is required for heat shock response induction in translationally inhibited cells, and specifically affects Hsf1 activation. Physiological heat-triggered acidification also increases population fitness and promotes cell cycle reentry following heat shock. Our results uncover a previously unknown adaptive dimension of the well-studied eukaryotic heat shock response." @default.
- W2889930424 created "2018-09-27" @default.
- W2889930424 creator A5035035885 @default.
- W2889930424 creator A5040351730 @default.
- W2889930424 creator A5057885534 @default.
- W2889930424 creator A5075498364 @default.
- W2889930424 date "2018-09-12" @default.
- W2889930424 modified "2023-10-05" @default.
- W2889930424 title "Transient intracellular acidification regulates the core transcriptional heat shock response" @default.
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- W2889930424 doi "https://doi.org/10.1101/414706" @default.
- W2889930424 hasPublicationYear "2018" @default.
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