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- W2889934166 endingPage "R544" @default.
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- W2889934166 abstract "Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) represent a group of heterogeneous tumors whose incidence increased over the past few years. Around half of patients already present with metastatic disease at the initial diagnosis. Despite extensive efforts, cytotoxic and targeted therapies have provided only limited efficacy for patients with metastatic GEP-NETs, mainly due to the development of a certain state of resistance. One factor contributing to both the failure of systemic therapies and the emergence of an aggressive tumor phenotype may be the tumor microenvironment (TME), comprising dynamic and adaptative assortment of extracellular matrix components and non-neoplastic cells, which surround the tumor niche. Accumulating evidence shows that the TME can simultaneously support both tumor growth and metastasis and contribute to a certain state of resistance to treatment. In this review, we summarize the current knowledge of the TME of GEP-NETs and discuss the current therapeutic agents that target GEP-NETs and those that could be of interest in the (near) future." @default.
- W2889934166 created "2018-09-27" @default.
- W2889934166 creator A5006066076 @default.
- W2889934166 creator A5023205638 @default.
- W2889934166 creator A5023302477 @default.
- W2889934166 creator A5077474914 @default.
- W2889934166 date "2018-11-01" @default.
- W2889934166 modified "2023-10-15" @default.
- W2889934166 title "Role of the tumor microenvironment in digestive neuroendocrine tumors" @default.
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