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- W2889956673 abstract "Thioquinomycins A-D (1–4), four novel naphthothiophenediones were isolated from the rice-based medium of the marine-derived Streptomyces sp. SS17F. Their structures were elucidated by spectroscopic methods and HRESIMS data. The absolute configurations of all the compounds were elucidated by X-ray diffraction analysis, ECD and Mosher's method combined with 19F-NMR. Compounds 1–4 showed moderate cytotoxicity against NCI-H1975 with IC50 values from 17.5 to 50 μM. In addition, compounds 1–4 also exhibited inhibitory activities against PKCα and ROCK2 protein kinase." @default.
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- W2889956673 date "2018-10-01" @default.
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- W2889956673 title "Thioquinomycins A-D, novel naphthothiophenediones from the marine-derived Streptomyces sp. SS17F" @default.
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- W2889956673 doi "https://doi.org/10.1016/j.tet.2018.09.007" @default.
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