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• W2889971454 abstract "Hereditary retinal degenerations result from varied pathophysiologic mechanisms, all ultimately characterized by photoreceptor dysfunction and death. Hence, much research on these diseases has concentrated on the outer retina. Over the past decade or so increasing attention has focused on concomitant changes in complex inner retinal neural circuits that process visual signals for transmission to the brain. One striking abnormality develops before the ultimately profound anatomic disruption of the inner retina. Highly elevated spontaneous activity was first demonstrated in central nervous system visual centers in vivo by Dräger and Hubel in 1978(Dräger and Hubel, 1978), and subsequently has been confirmed in vitro, now in multiple animal models and by multiple investigators (see other contributions to this Research Topic). What evidence exists that this phenomenon occurs in human patients with retinal degeneration , and what is the ultimate effect of spontaneous hyperactivity in the output neurons, the retinal ganglion cells? Here I summarize abnormalities of visual perception among patients with retinal degeneration that may arise from hyperactivity. Next, I consider the disruption of neural encoding and anatomic connectivity that may result within the retina and in downstream visual centers of the brain. I then consider how specific characteristics of hyperactivity may distinguish various forms or stages of retinal degeneration, potentially helping in the near future to refine diagnosis and/or treatment choices for different patients. Finally, I review how consideration of these features may help optimize pharmacologic, gene, stem cell, prosthetic or other therapies to forestall visual loss or restore sight." @default.
• W2889971454 created "2018-09-27" @default.
• W2889971454 creator A5023317256 @default.
• W2889971454 date "2018-09-10" @default.
• W2889971454 modified "2023-10-01" @default.
• W2889971454 title "Clinical Impact of Spontaneous Hyperactivity in Degenerating Retinas: Significance for Diagnosis, Symptoms, and Treatment" @default.
• W2889971454 cites W1524052462 @default.
• W2889971454 cites W1531428978 @default.
• W2889971454 cites W1555595315 @default.
• W2889971454 cites W1598740767 @default.
• W2889971454 cites W1601236881 @default.
• W2889971454 cites W1879003774 @default.
• W2889971454 cites W1909528068 @default.
• W2889971454 cites W1940907196 @default.
• W2889971454 cites W1970139807 @default.
• W2889971454 cites W1972094787 @default.
• W2889971454 cites W1972183128 @default.
• W2889971454 cites W1975606674 @default.
• W2889971454 cites W1978023046 @default.
• W2889971454 cites W1979152012 @default.
• W2889971454 cites W1985304131 @default.
• W2889971454 cites W1986162039 @default.
• W2889971454 cites W1992566820 @default.
• W2889971454 cites W1995875735 @default.
• W2889971454 cites W1997881805 @default.
• W2889971454 cites W2005171083 @default.
• W2889971454 cites W2006028506 @default.
• W2889971454 cites W2008693831 @default.
• W2889971454 cites W2010402950 @default.
• W2889971454 cites W2010667821 @default.
• W2889971454 cites W2014326203 @default.
• W2889971454 cites W2015127069 @default.
• W2889971454 cites W2030493365 @default.
• W2889971454 cites W2031017184 @default.
• W2889971454 cites W2038348058 @default.
• W2889971454 cites W2042090335 @default.
• W2889971454 cites W2045871212 @default.
• W2889971454 cites W2047719630 @default.
• W2889971454 cites W2048044998 @default.
• W2889971454 cites W2050215536 @default.
• W2889971454 cites W2057897219 @default.
• W2889971454 cites W2060742949 @default.
• W2889971454 cites W2066249645 @default.
• W2889971454 cites W2068459627 @default.
• W2889971454 cites W2069601330 @default.
• W2889971454 cites W2070521662 @default.
• W2889971454 cites W2075922024 @default.
• W2889971454 cites W2076550589 @default.
• W2889971454 cites W2079319133 @default.
• W2889971454 cites W2084232668 @default.
• W2889971454 cites W2087888706 @default.
• W2889971454 cites W2088454995 @default.
• W2889971454 cites W2098702533 @default.
• W2889971454 cites W2098834080 @default.
• W2889971454 cites W2101101880 @default.
• W2889971454 cites W2112165219 @default.
• W2889971454 cites W2119899246 @default.
• W2889971454 cites W2119912664 @default.
• W2889971454 cites W2147599445 @default.
• W2889971454 cites W2149243039 @default.
• W2889971454 cites W2149384040 @default.
• W2889971454 cites W2162290849 @default.
• W2889971454 cites W2162937730 @default.
• W2889971454 cites W2165154967 @default.
• W2889971454 cites W2201974140 @default.
• W2889971454 cites W2233854491 @default.
• W2889971454 cites W2261405855 @default.
• W2889971454 cites W227032276 @default.
• W2889971454 cites W2277274190 @default.
• W2889971454 cites W2282996874 @default.
• W2889971454 cites W2301247560 @default.
• W2889971454 cites W2324015353 @default.
• W2889971454 cites W2344933577 @default.
• W2889971454 cites W2371684294 @default.
• W2889971454 cites W2467199527 @default.
• W2889971454 cites W2510234293 @default.
• W2889971454 cites W2515985278 @default.
• W2889971454 cites W2521966295 @default.
• W2889971454 cites W2535577615 @default.
• W2889971454 cites W2555558852 @default.
• W2889971454 cites W2593082467 @default.
• W2889971454 cites W2594644573 @default.
• W2889971454 cites W2605702013 @default.
• W2889971454 cites W2619941164 @default.
• W2889971454 cites W2955336695 @default.
• W2889971454 doi "https://doi.org/10.3389/fncel.2018.00298" @default.
• W2889971454 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6139326" @default.
• W2889971454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30250425" @default.
• W2889971454 hasPublicationYear "2018" @default.
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