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- W2889975327 abstract "T follicular helper cells (Tfh) play crucial roles in the development of humoral immunity. In the B cell-rich germinal center of lymphoid organs, they select for high-affinity B cells and aid in their maturation. While Tfh have known roles in B cell malignancies and have prognostic value in some epithelial cancers, their role in lung tumour initiation and development is unknown. Through immune cell deconvolution, we observed significantly increased Tfh in tumours from two independent cohorts of lung adenocarcinomas and found that this upregulation occurs early in tumour development. A subset of tumours were stained for T and B cells using multicolour immunohistochemistry, which revealed the presence of tumour-adjacent tertiary lymphoid organs in 17/20 cases each with an average of 16 Tfh observed in the germinal center. Importantly, Tfh levels were correlated with tumour mutational load and immunogenic cancer testis antigens, suggesting their involvement in mounting an active immune response against tumour neoantigens." @default.
- W2889975327 created "2018-09-27" @default.
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- W2889975327 date "2018-09-06" @default.
- W2889975327 modified "2023-10-16" @default.
- W2889975327 title "Somatic mutation-associated T follicular helper cell elevation in lung adenocarcinoma" @default.
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- W2889975327 doi "https://doi.org/10.1080/2162402x.2018.1504728" @default.
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