FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889978063> ?p ?o ?g. }

• W2889978063 endingPage "67" @default.
• W2889978063 startingPage "61" @default.
• W2889978063 abstract "Intracerebral haemorrhage (ICH) is a common and devastating cerebrovascular disease with high morbidity and mortality, and its pathophysiological mechanisms were complex and still unclear. Increasing researches reported that microRNAs (miRNAs) played an important role in ICH-induced brain injury and microglial activation. In this study, we investigated the biological function of miR-590-5p and explored its molecular mechanism in ICH mice. The results of qRT-PCR showed that miR-590-5p expression level was down-regulated in perihematomal brain samples of ICH mice compared with that of sham group. In LPS-induced microglia cells, miR-590-5p level was also down-regulated at 24 h post-LPS compared with that of control group. Moreover, miR-590-5p overexpression remarkably increased the cerebral water content and neurological severity scores compared with that of scramble group in ICH mice. The production of inflammatory cytokine including IL-6, interleukin (IL)-1β, and tumor necrosis factor (TNF)-α in ICH mice was notably inhibited by miR-590-5p overexpression. Furthermore, the results of dual-luciferase reporter assay indicated that Pellino-1 (Peli1) was a direct target of miR-590-5p. MiR-590-5p overexpression remarkably inhibited the Peli1 gene expression both mRNA and protein levels. In addition, Peli1 overexpression partly abrogated the inhibitory effect of miR-590-5p mimic. Taken together, these datas suggested that miR-590-5p attenuated brain injury in ICH mice through inhibiting Peli1 gene expression, indicating that miR-590-5p may be a promising molecular target for ICH treatment." @default.
• W2889978063 created "2018-09-27" @default.
• W2889978063 creator A5049324634 @default.
• W2889978063 creator A5068586862 @default.
• W2889978063 creator A5070418184 @default.
• W2889978063 creator A5089051100 @default.
• W2889978063 creator A5090521812 @default.
• W2889978063 date "2018-09-01" @default.
• W2889978063 modified "2023-10-14" @default.
• W2889978063 title "MiR-590-5p alleviates intracerebral hemorrhage-induced brain injury through targeting Peli1 gene expression" @default.
• W2889978063 cites W1980443290 @default.
• W2889978063 cites W1981406821 @default.
• W2889978063 cites W1996003447 @default.
• W2889978063 cites W2000121863 @default.
• W2889978063 cites W2046379971 @default.
• W2889978063 cites W2047402120 @default.
• W2889978063 cites W2056034889 @default.
• W2889978063 cites W2060481603 @default.
• W2889978063 cites W2061415222 @default.
• W2889978063 cites W2078959438 @default.
• W2889978063 cites W2080548171 @default.
• W2889978063 cites W2089818768 @default.
• W2889978063 cites W2110572579 @default.
• W2889978063 cites W2112979354 @default.
• W2889978063 cites W2115445409 @default.
• W2889978063 cites W2123301364 @default.
• W2889978063 cites W2130894628 @default.
• W2889978063 cites W2136587148 @default.
• W2889978063 cites W2142878546 @default.
• W2889978063 cites W2165843498 @default.
• W2889978063 cites W2311134695 @default.
• W2889978063 cites W2334048186 @default.
• W2889978063 cites W2340113998 @default.
• W2889978063 cites W2417633482 @default.
• W2889978063 cites W2570334148 @default.
• W2889978063 cites W2606538712 @default.
• W2889978063 cites W2762753311 @default.
• W2889978063 cites W2769429041 @default.
• W2889978063 cites W2782074226 @default.
• W2889978063 cites W2786829261 @default.
• W2889978063 doi "https://doi.org/10.1016/j.bbrc.2018.08.121" @default.
• W2889978063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30190124" @default.
• W2889978063 hasPublicationYear "2018" @default.
• W2889978063 type Work @default.
• W2889978063 sameAs 2889978063 @default.
• W2889978063 citedByCount "15" @default.
• W2889978063 countsByYear W28899780632019 @default.
• W2889978063 countsByYear W28899780632020 @default.
• W2889978063 countsByYear W28899780632021 @default.
• W2889978063 countsByYear W28899780632022 @default.
• W2889978063 countsByYear W28899780632023 @default.
• W2889978063 crossrefType "journal-article" @default.
• W2889978063 hasAuthorship W2889978063A5049324634 @default.
• W2889978063 hasAuthorship W2889978063A5068586862 @default.
• W2889978063 hasAuthorship W2889978063A5070418184 @default.
• W2889978063 hasAuthorship W2889978063A5089051100 @default.
• W2889978063 hasAuthorship W2889978063A5090521812 @default.
• W2889978063 hasConcept C10162356 @default.
• W2889978063 hasConcept C104317684 @default.
• W2889978063 hasConcept C105580179 @default.
• W2889978063 hasConcept C126322002 @default.
• W2889978063 hasConcept C145059251 @default.
• W2889978063 hasConcept C150194340 @default.
• W2889978063 hasConcept C17991360 @default.
• W2889978063 hasConcept C203014093 @default.
• W2889978063 hasConcept C2776914184 @default.
• W2889978063 hasConcept C2777094939 @default.
• W2889978063 hasConcept C2777736543 @default.
• W2889978063 hasConcept C2778690821 @default.
• W2889978063 hasConcept C2779830541 @default.
• W2889978063 hasConcept C502942594 @default.
• W2889978063 hasConcept C55493867 @default.
• W2889978063 hasConcept C71924100 @default.
• W2889978063 hasConcept C86803240 @default.
• W2889978063 hasConcept C98274493 @default.
• W2889978063 hasConceptScore W2889978063C10162356 @default.
• W2889978063 hasConceptScore W2889978063C104317684 @default.
• W2889978063 hasConceptScore W2889978063C105580179 @default.
• W2889978063 hasConceptScore W2889978063C126322002 @default.
• W2889978063 hasConceptScore W2889978063C145059251 @default.
• W2889978063 hasConceptScore W2889978063C150194340 @default.
• W2889978063 hasConceptScore W2889978063C17991360 @default.
• W2889978063 hasConceptScore W2889978063C203014093 @default.
• W2889978063 hasConceptScore W2889978063C2776914184 @default.
• W2889978063 hasConceptScore W2889978063C2777094939 @default.
• W2889978063 hasConceptScore W2889978063C2777736543 @default.
• W2889978063 hasConceptScore W2889978063C2778690821 @default.
• W2889978063 hasConceptScore W2889978063C2779830541 @default.
• W2889978063 hasConceptScore W2889978063C502942594 @default.
• W2889978063 hasConceptScore W2889978063C55493867 @default.
• W2889978063 hasConceptScore W2889978063C71924100 @default.
• W2889978063 hasConceptScore W2889978063C86803240 @default.
• W2889978063 hasConceptScore W2889978063C98274493 @default.
• W2889978063 hasIssue "1" @default.
• W2889978063 hasLocation W28899780631 @default.
• W2889978063 hasLocation W28899780632 @default.
• W2889978063 hasOpenAccess W2889978063 @default.
• W2889978063 hasPrimaryLocation W28899780631 @default.

• next