Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889988932> ?p ?o ?g. }
- W2889988932 endingPage "2667" @default.
- W2889988932 startingPage "2667" @default.
- W2889988932 abstract "Melanin, the pigment produced by specialized cells, melanocytes, is responsible for skin and hair color. Skin pigmentation is an important protective mechanism against the DNA damaging and mutagenic effects of solar ultraviolet radiation (UV). It is acknowledged that exposure to UV is the main etiological environmental factor for all forms of skin cancer, including melanoma. DNA repair capacity is another major factor that determines the risk for skin cancer. Human melanocytes synthesize eumelanin, the dark brown form of melanin, as well as pheomelanin, which is reddish-yellow in color. The relative rates of eumelanin and pheomelanin synthesis by melanocytes determine skin color and the sensitivity of skin to the drastic effects of solar UV. Understanding the complex regulation of melanocyte function and how it responds to solar UV has a huge impact on developing novel photoprotective strategies to prevent skin cancer, particularly melanoma, the most fatal form, which originates from melanocytes. This review provides an overview of the known differences in the photoprotective effects of eumelanin versus pheomelanin, how these two forms of melanin are regulated genetically and biochemically, and their impact on the DNA damaging effects of UV exposure. Additionally, this review briefly discusses the role of paracrine factors, focusing on α-melanocortin (α-melanocyte stimulating hormone; α-MSH), in regulating melanogenesis and the response of melanocytes to UV, and describes a chemoprevention strategy based on targeting the melanocortin 1 receptor (MC1R) by analogs of its physiological agonist α-MSH." @default.
- W2889988932 created "2018-09-27" @default.
- W2889988932 creator A5000061916 @default.
- W2889988932 creator A5071835813 @default.
- W2889988932 date "2018-09-08" @default.
- W2889988932 modified "2023-10-17" @default.
- W2889988932 title "MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA Repair" @default.
- W2889988932 cites W1498791370 @default.
- W2889988932 cites W1524775751 @default.
- W2889988932 cites W1549263005 @default.
- W2889988932 cites W1639637038 @default.
- W2889988932 cites W1926874813 @default.
- W2889988932 cites W1938542587 @default.
- W2889988932 cites W1946161494 @default.
- W2889988932 cites W1964075996 @default.
- W2889988932 cites W1965740176 @default.
- W2889988932 cites W1969631786 @default.
- W2889988932 cites W1970716955 @default.
- W2889988932 cites W1971050728 @default.
- W2889988932 cites W1972828805 @default.
- W2889988932 cites W1972944775 @default.
- W2889988932 cites W1975658662 @default.
- W2889988932 cites W1977538828 @default.
- W2889988932 cites W1977632208 @default.
- W2889988932 cites W1979276428 @default.
- W2889988932 cites W1979420492 @default.
- W2889988932 cites W1979580952 @default.
- W2889988932 cites W1980720462 @default.
- W2889988932 cites W1982527304 @default.
- W2889988932 cites W1984482017 @default.
- W2889988932 cites W1985975702 @default.
- W2889988932 cites W1986702270 @default.
- W2889988932 cites W1989041278 @default.
- W2889988932 cites W1990492207 @default.
- W2889988932 cites W1995126053 @default.
- W2889988932 cites W1996393189 @default.
- W2889988932 cites W2000890539 @default.
- W2889988932 cites W2006809167 @default.
- W2889988932 cites W2006985041 @default.
- W2889988932 cites W2007821779 @default.
- W2889988932 cites W2008120376 @default.
- W2889988932 cites W2008663448 @default.
- W2889988932 cites W2011187106 @default.
- W2889988932 cites W2011531736 @default.
- W2889988932 cites W2020055953 @default.
- W2889988932 cites W2020078623 @default.
- W2889988932 cites W2020404856 @default.
- W2889988932 cites W2022205990 @default.
- W2889988932 cites W2022212425 @default.
- W2889988932 cites W2022732422 @default.
- W2889988932 cites W2028083892 @default.
- W2889988932 cites W2029980168 @default.
- W2889988932 cites W2032252903 @default.
- W2889988932 cites W2035825200 @default.
- W2889988932 cites W2038180878 @default.
- W2889988932 cites W2040527045 @default.
- W2889988932 cites W2040619287 @default.
- W2889988932 cites W2045853302 @default.
- W2889988932 cites W2047241095 @default.
- W2889988932 cites W2048019711 @default.
- W2889988932 cites W2048566663 @default.
- W2889988932 cites W2049581949 @default.
- W2889988932 cites W2050275563 @default.
- W2889988932 cites W2050938455 @default.
- W2889988932 cites W2051112657 @default.
- W2889988932 cites W2051361428 @default.
- W2889988932 cites W2055235209 @default.
- W2889988932 cites W2056019859 @default.
- W2889988932 cites W2059287983 @default.
- W2889988932 cites W2059304490 @default.
- W2889988932 cites W2059538032 @default.
- W2889988932 cites W2060573548 @default.
- W2889988932 cites W2064209090 @default.
- W2889988932 cites W2065243562 @default.
- W2889988932 cites W2066179353 @default.
- W2889988932 cites W2067390087 @default.
- W2889988932 cites W2069089202 @default.
- W2889988932 cites W2069423064 @default.
- W2889988932 cites W2072328142 @default.
- W2889988932 cites W2073962547 @default.
- W2889988932 cites W2078820161 @default.
- W2889988932 cites W2078880170 @default.
- W2889988932 cites W2080349213 @default.
- W2889988932 cites W2080559511 @default.
- W2889988932 cites W2082966799 @default.
- W2889988932 cites W2085408843 @default.
- W2889988932 cites W2088861488 @default.
- W2889988932 cites W2089951482 @default.
- W2889988932 cites W2093971029 @default.
- W2889988932 cites W2094828639 @default.
- W2889988932 cites W2101852419 @default.
- W2889988932 cites W2102568364 @default.
- W2889988932 cites W2103633212 @default.
- W2889988932 cites W2103667120 @default.
- W2889988932 cites W2109511835 @default.
- W2889988932 cites W2115022580 @default.
- W2889988932 cites W2116893702 @default.
- W2889988932 cites W2123439746 @default.