Matches in SemOpenAlex for { <https://semopenalex.org/work/W2889996140> ?p ?o ?g. }
- W2889996140 endingPage "183" @default.
- W2889996140 startingPage "177" @default.
- W2889996140 abstract "Systemic sclerosis (SSc) is a rare autoimmune disease that is characterized by fibrosis, inflammation, and vasculopathy of the skin and internal organs. The etiopathogenesis of SSc remains unclear. However, the pivotal role of T lymphocytes with an aberrant immune response in SSc is well established. Among T cells, IL-17-producing helper T (Th17) cell and regulatory T (Treg) cell subsets have recently been found to play crucial roles in SSc pathogenesis. Generally speaking, Th17 cell subsets up-regulate inflammation, fibrosis, and autoimmunity, which are present in SSc, while Treg cell subsets have an immunosuppressive function and resist the immunological performance of Th17 cells. Up-to-date evidence has pointed out that the imbalance and abnormal functions of Th17/Treg cells may contribute to SSc. Therefore, this review aims to summarize the current understanding of the vital cytokines and signaling pathways that are involved in Th17/Treg differentiation and functions, and their roles in the pathogenesis of SSc, thus providing novel insights about targeting the Th17/Treg balance as a potential therapy for SSc treatment in the near future." @default.
- W2889996140 created "2018-09-27" @default.
- W2889996140 creator A5006121037 @default.
- W2889996140 creator A5013735636 @default.
- W2889996140 creator A5016288034 @default.
- W2889996140 creator A5039556450 @default.
- W2889996140 creator A5061550044 @default.
- W2889996140 date "2018-12-01" @default.
- W2889996140 modified "2023-10-18" @default.
- W2889996140 title "Imbalance between T helper 17 and regulatory T cell subsets plays a significant role in the pathogenesis of systemic sclerosis" @default.
- W2889996140 cites W1505701939 @default.
- W2889996140 cites W1557073002 @default.
- W2889996140 cites W1587788435 @default.
- W2889996140 cites W1842591800 @default.
- W2889996140 cites W1895601060 @default.
- W2889996140 cites W1964002654 @default.
- W2889996140 cites W1967350651 @default.
- W2889996140 cites W1971079822 @default.
- W2889996140 cites W1973107366 @default.
- W2889996140 cites W1978675331 @default.
- W2889996140 cites W1980962072 @default.
- W2889996140 cites W1986017638 @default.
- W2889996140 cites W1988193674 @default.
- W2889996140 cites W1991268098 @default.
- W2889996140 cites W1991381323 @default.
- W2889996140 cites W1992465548 @default.
- W2889996140 cites W1993740812 @default.
- W2889996140 cites W1995153287 @default.
- W2889996140 cites W1996032049 @default.
- W2889996140 cites W1998481877 @default.
- W2889996140 cites W2005903993 @default.
- W2889996140 cites W2006249161 @default.
- W2889996140 cites W2007662048 @default.
- W2889996140 cites W2008279293 @default.
- W2889996140 cites W2008512592 @default.
- W2889996140 cites W2009155133 @default.
- W2889996140 cites W2014540704 @default.
- W2889996140 cites W2014750930 @default.
- W2889996140 cites W2018166175 @default.
- W2889996140 cites W2020483976 @default.
- W2889996140 cites W2025375121 @default.
- W2889996140 cites W2025928292 @default.
- W2889996140 cites W2029520442 @default.
- W2889996140 cites W2033329215 @default.
- W2889996140 cites W2035286023 @default.
- W2889996140 cites W2036383793 @default.
- W2889996140 cites W2041179006 @default.
- W2889996140 cites W2042586707 @default.
- W2889996140 cites W2045752938 @default.
- W2889996140 cites W2045995185 @default.
- W2889996140 cites W2054131359 @default.
- W2889996140 cites W2059158081 @default.
- W2889996140 cites W2062194717 @default.
- W2889996140 cites W2063203559 @default.
- W2889996140 cites W2064645845 @default.
- W2889996140 cites W2065949135 @default.
- W2889996140 cites W2067885308 @default.
- W2889996140 cites W2074780505 @default.
- W2889996140 cites W2074851020 @default.
- W2889996140 cites W2076234796 @default.
- W2889996140 cites W2078871554 @default.
- W2889996140 cites W2078918202 @default.
- W2889996140 cites W2080941879 @default.
- W2889996140 cites W2082225392 @default.
- W2889996140 cites W2082329311 @default.
- W2889996140 cites W2087472552 @default.
- W2889996140 cites W2087637747 @default.
- W2889996140 cites W2089810611 @default.
- W2889996140 cites W2095301638 @default.
- W2889996140 cites W2099092772 @default.
- W2889996140 cites W2099495167 @default.
- W2889996140 cites W2102010541 @default.
- W2889996140 cites W2103760280 @default.
- W2889996140 cites W2104383189 @default.
- W2889996140 cites W2109414252 @default.
- W2889996140 cites W2110873592 @default.
- W2889996140 cites W2111028384 @default.
- W2889996140 cites W2112119237 @default.
- W2889996140 cites W2112220475 @default.
- W2889996140 cites W2115634207 @default.
- W2889996140 cites W2116118634 @default.
- W2889996140 cites W2119186342 @default.
- W2889996140 cites W2120010406 @default.
- W2889996140 cites W2134641700 @default.
- W2889996140 cites W2135735750 @default.
- W2889996140 cites W2141649011 @default.
- W2889996140 cites W2142877732 @default.
- W2889996140 cites W2143168086 @default.
- W2889996140 cites W2145152452 @default.
- W2889996140 cites W2146945647 @default.
- W2889996140 cites W2147993391 @default.
- W2889996140 cites W2151226131 @default.
- W2889996140 cites W2155779547 @default.
- W2889996140 cites W2156039834 @default.
- W2889996140 cites W2162843964 @default.
- W2889996140 cites W2163938125 @default.
- W2889996140 cites W2166503846 @default.
- W2889996140 cites W2167297937 @default.