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- W2890008542 abstract "Epilepsy is characterized by the regular occurrence of seizures, which follow a stereotypical sequence of alterations in the electroencephalogram. Seizures are typically a self limiting phenomenon, concluding finally in the cessation of hypersynchronous activity and followed by a state of decreased neuronal excitability which might underlie the cognitive and psychological symptoms the patients experience in the wake of seizures. Many efforts have been devoted to understand how seizures spontaneously stop in hope to exploit this knowledge in anticonvulsant or neuroprotective therapies. Besides the alterations in ion-channels, transmitters and neuromodulators, the successive build up of disturbances in energy metabolism have been suggested as a mechanism for seizure termination. Energy metabolism and substrate supply of the brain are tightly regulated by different mechanisms called neurometabolic and neurovascular coupling. Here we summarize the current knowledge whether these mechanisms are sufficient to cover the energy demand of hypersynchronous activity and whether a mismatch between energy need and supply could contribute to seizure control." @default.
- W2890008542 created "2018-09-27" @default.
- W2890008542 creator A5003585109 @default.
- W2890008542 creator A5021126315 @default.
- W2890008542 creator A5040811208 @default.
- W2890008542 creator A5058155157 @default.
- W2890008542 creator A5071194180 @default.
- W2890008542 creator A5071327842 @default.
- W2890008542 creator A5084514547 @default.
- W2890008542 date "2018-10-08" @default.
- W2890008542 modified "2023-10-17" @default.
- W2890008542 title "Bioenergetic Mechanisms of Seizure Control" @default.
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