FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890070691> ?p ?o ?g. }

• W2890070691 abstract "Innate antiviral immunity establishes first line of defence against invading pathogens through sensing their molecular structures such as viral RNA. This antiviral potential of innate immunity is mainly attributed to a myriad of IFN-stimulated genes (ISGs). Amongst well-characterized ISGs, we have previously shown that antiviral potential of chicken IFN-induced proteins with tetratricopeptides repeats 5 (chIFIT5) is determined by its interaction potential with 5’ppp containing viral RNA. Here, we generated transgenic chickens using avian sarcoma-leukosis virus (RCAS)-based gene transfer system that constitutively and stably express chIFIT5. The transgenic chickens infected with clinical dose (EID50 104 for HPAIV and 105 EID50 for vNDV) of high pathogenicity avian influenza virus (HPAIV; H5N1) or velogenic strain of Newcastle disease virus (vNDV; Genotype VII) showed marked resistance against infections. While transgenic chickens failed to sustain a lethal dose of these viruses (EID50 105 for HPAIV and 106 EID50 for vNDV), a delayed and lower level of clinical disease and mortality, reduced virus shedding and tissue damage was observed compared to non-transgenic control chickens. These observations suggest that stable expression of chIFIT5 alone is potentially insufficient in providing sterile protection against these highly virulent viruses; however, it is sufficient to ameliorate the clinical outcome of these RNA viruses. These findings propose the potential of innate immune genes in conferring genetic resistance in chickens against highly pathogenic and zoonotic viral pathogens causing sever disease in both animals and humans." @default.
• W2890070691 created "2018-09-27" @default.
• W2890070691 creator A5004611972 @default.
• W2890070691 creator A5020955241 @default.
• W2890070691 creator A5023689347 @default.
• W2890070691 creator A5031219376 @default.
• W2890070691 creator A5034814485 @default.
• W2890070691 creator A5048996229 @default.
• W2890070691 date "2018-09-14" @default.
• W2890070691 modified "2023-10-17" @default.
• W2890070691 title "Chickens Expressing IFIT5 Ameliorate Clinical Outcome and Pathology of Highly Pathogenic Avian Influenza and Velogenic Newcastle Disease Viruses" @default.
• W2890070691 cites W1843467217 @default.
• W2890070691 cites W1966902552 @default.
• W2890070691 cites W1967310385 @default.
• W2890070691 cites W1979838502 @default.
• W2890070691 cites W1993450831 @default.
• W2890070691 cites W2004727967 @default.
• W2890070691 cites W2013688915 @default.
• W2890070691 cites W2044818544 @default.
• W2890070691 cites W2063310200 @default.
• W2890070691 cites W206794969 @default.
• W2890070691 cites W2074399085 @default.
• W2890070691 cites W2076039408 @default.
• W2890070691 cites W2076198632 @default.
• W2890070691 cites W2079510563 @default.
• W2890070691 cites W2086004955 @default.
• W2890070691 cites W2096372976 @default.
• W2890070691 cites W2104373123 @default.
• W2890070691 cites W2121608531 @default.
• W2890070691 cites W2141659272 @default.
• W2890070691 cites W2146046197 @default.
• W2890070691 cites W2154107622 @default.
• W2890070691 cites W2156286727 @default.
• W2890070691 cites W2256756668 @default.
• W2890070691 cites W2274721624 @default.
• W2890070691 cites W2580190897 @default.
• W2890070691 cites W2802897459 @default.
• W2890070691 doi "https://doi.org/10.3389/fimmu.2018.02025" @default.
• W2890070691 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6149294" @default.
• W2890070691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30271403" @default.
• W2890070691 hasPublicationYear "2018" @default.
• W2890070691 type Work @default.
• W2890070691 sameAs 2890070691 @default.
• W2890070691 citedByCount "23" @default.
• W2890070691 countsByYear W28900706912018 @default.
• W2890070691 countsByYear W28900706912019 @default.
• W2890070691 countsByYear W28900706912020 @default.
• W2890070691 countsByYear W28900706912021 @default.
• W2890070691 countsByYear W28900706912022 @default.
• W2890070691 crossrefType "journal-article" @default.
• W2890070691 hasAuthorship W2890070691A5004611972 @default.
• W2890070691 hasAuthorship W2890070691A5020955241 @default.
• W2890070691 hasAuthorship W2890070691A5023689347 @default.
• W2890070691 hasAuthorship W2890070691A5031219376 @default.
• W2890070691 hasAuthorship W2890070691A5034814485 @default.
• W2890070691 hasAuthorship W2890070691A5048996229 @default.
• W2890070691 hasBestOaLocation W28900706911 @default.
• W2890070691 hasConcept C102230213 @default.
• W2890070691 hasConcept C104317684 @default.
• W2890070691 hasConcept C12914427 @default.
• W2890070691 hasConcept C136449434 @default.
• W2890070691 hasConcept C159047783 @default.
• W2890070691 hasConcept C203014093 @default.
• W2890070691 hasConcept C2522874641 @default.
• W2890070691 hasConcept C2778116459 @default.
• W2890070691 hasConcept C2779341262 @default.
• W2890070691 hasConcept C519248777 @default.
• W2890070691 hasConcept C54355233 @default.
• W2890070691 hasConcept C86803240 @default.
• W2890070691 hasConcept C8891405 @default.
• W2890070691 hasConceptScore W2890070691C102230213 @default.
• W2890070691 hasConceptScore W2890070691C104317684 @default.
• W2890070691 hasConceptScore W2890070691C12914427 @default.
• W2890070691 hasConceptScore W2890070691C136449434 @default.
• W2890070691 hasConceptScore W2890070691C159047783 @default.
• W2890070691 hasConceptScore W2890070691C203014093 @default.
• W2890070691 hasConceptScore W2890070691C2522874641 @default.
• W2890070691 hasConceptScore W2890070691C2778116459 @default.
• W2890070691 hasConceptScore W2890070691C2779341262 @default.
• W2890070691 hasConceptScore W2890070691C519248777 @default.
• W2890070691 hasConceptScore W2890070691C54355233 @default.
• W2890070691 hasConceptScore W2890070691C86803240 @default.
• W2890070691 hasConceptScore W2890070691C8891405 @default.
• W2890070691 hasFunder F4320334629 @default.
• W2890070691 hasLocation W28900706911 @default.
• W2890070691 hasLocation W28900706912 @default.
• W2890070691 hasLocation W28900706913 @default.
• W2890070691 hasLocation W28900706914 @default.
• W2890070691 hasLocation W28900706915 @default.
• W2890070691 hasOpenAccess W2890070691 @default.
• W2890070691 hasPrimaryLocation W28900706911 @default.
• W2890070691 hasRelatedWork W2010010813 @default.
• W2890070691 hasRelatedWork W2038228839 @default.
• W2890070691 hasRelatedWork W2299844689 @default.
• W2890070691 hasRelatedWork W2353059136 @default.
• W2890070691 hasRelatedWork W2765734579 @default.
• W2890070691 hasRelatedWork W2905557232 @default.
• W2890070691 hasRelatedWork W2948121398 @default.
• W2890070691 hasRelatedWork W2991182793 @default.
• W2890070691 hasRelatedWork W3025407957 @default.

• next