Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890074320> ?p ?o ?g. }
- W2890074320 endingPage "246" @default.
- W2890074320 startingPage "230" @default.
- W2890074320 abstract "A perturbed maternal metabolic environment such as chronically elevated circulating free fatty acids have been shown to affect stem cell fate during embryonic neurogenesis. However, molecular mechanisms behind this are not well defined, especially in human. Here in using directed differentiation of human embryonic stem cells (hESCs) into cortical neurons as model, we show that chronically elevated saturated fatty acid (palmitate) results in decreased proliferation of neural stem cells and increased differentiation into neurons. This phenotype could be due to palmitate mediated increased expression of key genes needed for neuronal differentiation such as EOMES, TBR1, NEUROD1 and RELN and reduced expression of SREBP regulated lipogenic genes at early stages of cortical differentiation. Furthermore, palmitate treatment increased histone acetylation globally and at select gene promoters among affected genes. We also found differential expression of several lncRNAs associated with cellular stress and metabolic diseases in the presence of palmitate including BDNF-AS suggesting the contribution of additional epigenetic regulatory mechanisms. Together, our results show that saturated fatty acid affects developmental neurogenesis through modulation of gene expression and through epigenetic regulatory mechanisms." @default.
- W2890074320 created "2018-09-27" @default.
- W2890074320 creator A5019624734 @default.
- W2890074320 creator A5035537833 @default.
- W2890074320 creator A5049245142 @default.
- W2890074320 creator A5066216564 @default.
- W2890074320 creator A5083920789 @default.
- W2890074320 date "2018-12-01" @default.
- W2890074320 modified "2023-10-18" @default.
- W2890074320 title "Saturated fatty acid alters embryonic cortical neurogenesis through modulation of gene expression in neural stem cells" @default.
- W2890074320 cites W1829176850 @default.
- W2890074320 cites W1861340857 @default.
- W2890074320 cites W1911930811 @default.
- W2890074320 cites W1930479200 @default.
- W2890074320 cites W1960956557 @default.
- W2890074320 cites W1966955323 @default.
- W2890074320 cites W1982761508 @default.
- W2890074320 cites W1984413737 @default.
- W2890074320 cites W1986062299 @default.
- W2890074320 cites W1986458716 @default.
- W2890074320 cites W1990935914 @default.
- W2890074320 cites W1994083528 @default.
- W2890074320 cites W1994580320 @default.
- W2890074320 cites W1995540659 @default.
- W2890074320 cites W1996613017 @default.
- W2890074320 cites W1996849842 @default.
- W2890074320 cites W1996897145 @default.
- W2890074320 cites W2001730700 @default.
- W2890074320 cites W2007154912 @default.
- W2890074320 cites W2012795308 @default.
- W2890074320 cites W2013101568 @default.
- W2890074320 cites W2019348805 @default.
- W2890074320 cites W2029812020 @default.
- W2890074320 cites W2032804593 @default.
- W2890074320 cites W2035242839 @default.
- W2890074320 cites W2043439734 @default.
- W2890074320 cites W2051393353 @default.
- W2890074320 cites W2058697507 @default.
- W2890074320 cites W2068989963 @default.
- W2890074320 cites W2069139855 @default.
- W2890074320 cites W2079965790 @default.
- W2890074320 cites W2080818732 @default.
- W2890074320 cites W2086507603 @default.
- W2890074320 cites W2092537435 @default.
- W2890074320 cites W2093296161 @default.
- W2890074320 cites W2096589182 @default.
- W2890074320 cites W2101284986 @default.
- W2890074320 cites W2104490470 @default.
- W2890074320 cites W2110778540 @default.
- W2890074320 cites W2114413271 @default.
- W2890074320 cites W2114763647 @default.
- W2890074320 cites W2117993672 @default.
- W2890074320 cites W2120495406 @default.
- W2890074320 cites W2120667767 @default.
- W2890074320 cites W2143981060 @default.
- W2890074320 cites W2145757273 @default.
- W2890074320 cites W2152294954 @default.
- W2890074320 cites W2152552164 @default.
- W2890074320 cites W2158880125 @default.
- W2890074320 cites W2159999899 @default.
- W2890074320 cites W2161612015 @default.
- W2890074320 cites W2162187216 @default.
- W2890074320 cites W2163484250 @default.
- W2890074320 cites W2166552936 @default.
- W2890074320 cites W2169162266 @default.
- W2890074320 cites W2171253460 @default.
- W2890074320 cites W2171460953 @default.
- W2890074320 cites W2257408058 @default.
- W2890074320 cites W2270074037 @default.
- W2890074320 cites W2280199365 @default.
- W2890074320 cites W2343887501 @default.
- W2890074320 cites W2525747862 @default.
- W2890074320 cites W2547714582 @default.
- W2890074320 cites W2549902875 @default.
- W2890074320 cites W2558874063 @default.
- W2890074320 cites W2559618992 @default.
- W2890074320 cites W2576246142 @default.
- W2890074320 cites W2579993209 @default.
- W2890074320 cites W2615184377 @default.
- W2890074320 cites W2615783764 @default.
- W2890074320 cites W2619972691 @default.
- W2890074320 cites W2750665224 @default.
- W2890074320 cites W2757619255 @default.
- W2890074320 cites W2763087558 @default.
- W2890074320 cites W2780630613 @default.
- W2890074320 cites W2790720651 @default.
- W2890074320 cites W2792873661 @default.
- W2890074320 cites W2898416867 @default.
- W2890074320 doi "https://doi.org/10.1016/j.jnutbio.2018.09.006" @default.
- W2890074320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30317068" @default.
- W2890074320 hasPublicationYear "2018" @default.
- W2890074320 type Work @default.
- W2890074320 sameAs 2890074320 @default.
- W2890074320 citedByCount "11" @default.
- W2890074320 countsByYear W28900743202018 @default.
- W2890074320 countsByYear W28900743202019 @default.
- W2890074320 countsByYear W28900743202020 @default.
- W2890074320 countsByYear W28900743202021 @default.