Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890104859> ?p ?o ?g. }
- W2890104859 abstract "Significance Mast cells are mandatory for allergic reactions and participate in inflammatory responses in which the peptide substance P (SP) and the cytokine IL-33 are involved. This report shows that SP administered together with IL-33 to cultured human mast cells causes a marked increase in the secretion and gene expression of IL-1β. These responses are mediated via the activation of the SP receptor NK-1 and the IL-33 receptor ST2 and can be inhibited by the natural flavonoid methoxyluteolin. These findings highlight the important role of SP and IL-33 in mast cell secretion of IL-1β and point to targets for the development of therapies for inflammatory diseases." @default.
- W2890104859 created "2018-09-27" @default.
- W2890104859 creator A5053523675 @default.
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- W2890104859 creator A5079468194 @default.
- W2890104859 creator A5085356549 @default.
- W2890104859 creator A5086565751 @default.
- W2890104859 date "2018-09-19" @default.
- W2890104859 modified "2023-10-13" @default.
- W2890104859 title "Substance P and IL-33 administered together stimulate a marked secretion of IL-1β from human mast cells, inhibited by methoxyluteolin" @default.
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- W2890104859 doi "https://doi.org/10.1073/pnas.1810133115" @default.
- W2890104859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6176605" @default.
- W2890104859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30232261" @default.
- W2890104859 hasPublicationYear "2018" @default.
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