Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890106957> ?p ?o ?g. }
- W2890106957 endingPage "3007.e3" @default.
- W2890106957 startingPage "3000" @default.
- W2890106957 abstract "Rhinovirus is a leading cause of acute respiratory infections and asthma attacks, but infections are also frequently cleared from the nasal mucosa without causing symptoms. We sought to better understand host defense against rhinovirus by investigating antiviral defense in primary human nasal and bronchial airway epithelial cells cultured ex vivo. Surprisingly, upon rhinovirus infection or RIG-I stimulation, nasal-derived epithelial cells exhibited much more robust antiviral responses than bronchial-derived cells. Conversely, RIG-I stimulation triggered more robust activation of the NRF2-dependent oxidative stress response in bronchial cells compared to nasal cells. NRF2 activation dampened epithelial antiviral responses, whereas NRF2 knockdown enhanced antiviral responses and was protective during rhinovirus infection. These findings demonstrate a tradeoff in epithelial defense against distinct types of airway damage, namely, viral versus oxidative, and reveal differential calibration of defense responses in cells derived from different airway microenvironments." @default.
- W2890106957 created "2018-09-27" @default.
- W2890106957 creator A5003399137 @default.
- W2890106957 creator A5003740904 @default.
- W2890106957 creator A5007909912 @default.
- W2890106957 creator A5010263068 @default.
- W2890106957 creator A5016891336 @default.
- W2890106957 creator A5023884031 @default.
- W2890106957 creator A5081608753 @default.
- W2890106957 creator A5088010294 @default.
- W2890106957 date "2018-09-01" @default.
- W2890106957 modified "2023-10-15" @default.
- W2890106957 title "Regional Differences in Airway Epithelial Cells Reveal Tradeoff between Defense against Oxidative Stress and Defense against Rhinovirus" @default.
- W2890106957 cites W1912934531 @default.
- W2890106957 cites W2004765105 @default.
- W2890106957 cites W2007736853 @default.
- W2890106957 cites W2012382065 @default.
- W2890106957 cites W2020541351 @default.
- W2890106957 cites W2023620934 @default.
- W2890106957 cites W2039569747 @default.
- W2890106957 cites W2043161346 @default.
- W2890106957 cites W2050317906 @default.
- W2890106957 cites W2060261524 @default.
- W2890106957 cites W2062762897 @default.
- W2890106957 cites W2064176746 @default.
- W2890106957 cites W2065445260 @default.
- W2890106957 cites W2065864183 @default.
- W2890106957 cites W2070077343 @default.
- W2890106957 cites W2080958324 @default.
- W2890106957 cites W2096261918 @default.
- W2890106957 cites W2101412709 @default.
- W2890106957 cites W2103567438 @default.
- W2890106957 cites W2103649986 @default.
- W2890106957 cites W2106106042 @default.
- W2890106957 cites W2107286925 @default.
- W2890106957 cites W2107533173 @default.
- W2890106957 cites W2112024809 @default.
- W2890106957 cites W2112433605 @default.
- W2890106957 cites W2112602467 @default.
- W2890106957 cites W2117800935 @default.
- W2890106957 cites W2127036378 @default.
- W2890106957 cites W2140729960 @default.
- W2890106957 cites W2179438025 @default.
- W2890106957 cites W2400239628 @default.
- W2890106957 cites W2429603187 @default.
- W2890106957 cites W2463635797 @default.
- W2890106957 cites W2516140428 @default.
- W2890106957 cites W2548618596 @default.
- W2890106957 cites W2557403528 @default.
- W2890106957 cites W2748586815 @default.
- W2890106957 cites W2750054522 @default.
- W2890106957 cites W2780398602 @default.
- W2890106957 cites W4243831105 @default.
- W2890106957 cites W952491933 @default.
- W2890106957 doi "https://doi.org/10.1016/j.celrep.2018.08.033" @default.
- W2890106957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6190718" @default.
- W2890106957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30208323" @default.
- W2890106957 hasPublicationYear "2018" @default.
- W2890106957 type Work @default.
- W2890106957 sameAs 2890106957 @default.
- W2890106957 citedByCount "42" @default.
- W2890106957 countsByYear W28901069572019 @default.
- W2890106957 countsByYear W28901069572020 @default.
- W2890106957 countsByYear W28901069572021 @default.
- W2890106957 countsByYear W28901069572022 @default.
- W2890106957 countsByYear W28901069572023 @default.
- W2890106957 crossrefType "journal-article" @default.
- W2890106957 hasAuthorship W2890106957A5003399137 @default.
- W2890106957 hasAuthorship W2890106957A5003740904 @default.
- W2890106957 hasAuthorship W2890106957A5007909912 @default.
- W2890106957 hasAuthorship W2890106957A5010263068 @default.
- W2890106957 hasAuthorship W2890106957A5016891336 @default.
- W2890106957 hasAuthorship W2890106957A5023884031 @default.
- W2890106957 hasAuthorship W2890106957A5081608753 @default.
- W2890106957 hasAuthorship W2890106957A5088010294 @default.
- W2890106957 hasBestOaLocation W28901069571 @default.
- W2890106957 hasConcept C105702510 @default.
- W2890106957 hasConcept C105922876 @default.
- W2890106957 hasConcept C141071460 @default.
- W2890106957 hasConcept C142724271 @default.
- W2890106957 hasConcept C169760540 @default.
- W2890106957 hasConcept C203014093 @default.
- W2890106957 hasConcept C24998067 @default.
- W2890106957 hasConcept C2522874641 @default.
- W2890106957 hasConcept C2776151105 @default.
- W2890106957 hasConcept C2776914184 @default.
- W2890106957 hasConcept C2779278377 @default.
- W2890106957 hasConcept C529295009 @default.
- W2890106957 hasConcept C534529494 @default.
- W2890106957 hasConcept C55493867 @default.
- W2890106957 hasConcept C71924100 @default.
- W2890106957 hasConcept C86803240 @default.
- W2890106957 hasConcept C87568996 @default.
- W2890106957 hasConceptScore W2890106957C105702510 @default.
- W2890106957 hasConceptScore W2890106957C105922876 @default.
- W2890106957 hasConceptScore W2890106957C141071460 @default.
- W2890106957 hasConceptScore W2890106957C142724271 @default.
- W2890106957 hasConceptScore W2890106957C169760540 @default.