FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890107192> ?p ?o ?g. }

• W2890107192 endingPage "9660" @default.
• W2890107192 startingPage "9658" @default.
• W2890107192 abstract "Tuberculosis (TB) is currently the leading cause of mortality from a single infectious agent, resulting in more than 1.5 million deaths annually. In 2016, 10.4 million people developed the disease (1), of whom 490,000 had multidrug-resistant TB, defined as resistant to the two first-line drugs, isoniazid (INH) and rifampicin. Given that combination chemotherapies against the causative agent, Mycobacterium tuberculosis ( Mtb ), form the cornerstone of TB control, these stark statistics underscore the urgent need for new drugs to tackle this global health scourge. In response to this need, a pipeline has been established that has begun to deliver new and repurposed TB drugs (2). Key attributes for new drugs include efficacy against drug-resistant as well as drug-sensitive TB and an ability to effect a rapid, relapse-free (i.e., sterilizing) cure. These requirements have placed a high premium on the identification and validation of new targets, which differ from those of existing TB drugs, coupled with the development of potent compounds that will kill Mtb rapidly upon target engagement. This is a tall order for a notoriously underresourced field of research (3).In PNAS, Tiwari et al. (4) contribute to this endeavor by reporting the identification of two promising new TB drug targets: acetyl glutamate kinase (ArgB) and ornithine carbamoyl transferase (ArgF). These enzymes catalyze the second and sixth steps, respectively, in the pathway for the de novo biosynthesis of the amino acid l-arginine, from l-glutamate in Mtb (Fig. 1). The work of Tiwari et al. began with the observation that a feature common to the mycobactericidal agents, INH and vitamin C, is an ability to kill Mtb rapidly via a mechanism associated with the production of reactive oxygen species (ROS) (5). Using transcriptional profiling to investigate the effects of INH and vitamin C exposure on mycobacterial cellular metabolism, Tiwari … [↵][1]1To whom correspondence should be addressed. Email: valerie.mizrahi{at}uct.ac.za. [1]: #xref-corresp-1-1" @default.
• W2890107192 created "2018-09-27" @default.
• W2890107192 creator A5057584977 @default.
• W2890107192 creator A5072243737 @default.
• W2890107192 date "2018-09-06" @default.
• W2890107192 modified "2023-10-15" @default.
• W2890107192 title "Death of <i>Mycobacterium tuberculosis</i> by <scp>l</scp> -arginine starvation" @default.
• W2890107192 cites W1983275536 @default.
• W2890107192 cites W2064939702 @default.
• W2890107192 cites W2114902148 @default.
• W2890107192 cites W2127639177 @default.
• W2890107192 cites W2140867711 @default.
• W2890107192 cites W2144173375 @default.
• W2890107192 cites W2167156367 @default.
• W2890107192 cites W2526044420 @default.
• W2890107192 cites W2528123476 @default.
• W2890107192 cites W2599413193 @default.
• W2890107192 cites W2624822716 @default.
• W2890107192 cites W2728618210 @default.
• W2890107192 cites W2786275130 @default.
• W2890107192 cites W2788749261 @default.
• W2890107192 cites W2790000240 @default.
• W2890107192 cites W2792950947 @default.
• W2890107192 cites W2793848865 @default.
• W2890107192 cites W2795343849 @default.
• W2890107192 cites W2888763868 @default.
• W2890107192 doi "https://doi.org/10.1073/pnas.1813587115" @default.
• W2890107192 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6166815" @default.
• W2890107192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30190428" @default.
• W2890107192 hasPublicationYear "2018" @default.
• W2890107192 type Work @default.
• W2890107192 sameAs 2890107192 @default.
• W2890107192 citedByCount "9" @default.
• W2890107192 countsByYear W28901071922019 @default.
• W2890107192 countsByYear W28901071922020 @default.
• W2890107192 countsByYear W28901071922021 @default.
• W2890107192 countsByYear W28901071922023 @default.
• W2890107192 crossrefType "journal-article" @default.
• W2890107192 hasAuthorship W2890107192A5057584977 @default.
• W2890107192 hasAuthorship W2890107192A5072243737 @default.
• W2890107192 hasBestOaLocation W28901071921 @default.
• W2890107192 hasConcept C134018914 @default.
• W2890107192 hasConcept C142724271 @default.
• W2890107192 hasConcept C185592680 @default.
• W2890107192 hasConcept C2777468819 @default.
• W2890107192 hasConcept C2777975735 @default.
• W2890107192 hasConcept C2780606744 @default.
• W2890107192 hasConcept C2781069245 @default.
• W2890107192 hasConcept C515207424 @default.
• W2890107192 hasConcept C523546767 @default.
• W2890107192 hasConcept C54355233 @default.
• W2890107192 hasConcept C55493867 @default.
• W2890107192 hasConcept C71924100 @default.
• W2890107192 hasConcept C86803240 @default.
• W2890107192 hasConcept C89423630 @default.
• W2890107192 hasConceptScore W2890107192C134018914 @default.
• W2890107192 hasConceptScore W2890107192C142724271 @default.
• W2890107192 hasConceptScore W2890107192C185592680 @default.
• W2890107192 hasConceptScore W2890107192C2777468819 @default.
• W2890107192 hasConceptScore W2890107192C2777975735 @default.
• W2890107192 hasConceptScore W2890107192C2780606744 @default.
• W2890107192 hasConceptScore W2890107192C2781069245 @default.
• W2890107192 hasConceptScore W2890107192C515207424 @default.
• W2890107192 hasConceptScore W2890107192C523546767 @default.
• W2890107192 hasConceptScore W2890107192C54355233 @default.
• W2890107192 hasConceptScore W2890107192C55493867 @default.
• W2890107192 hasConceptScore W2890107192C71924100 @default.
• W2890107192 hasConceptScore W2890107192C86803240 @default.
• W2890107192 hasConceptScore W2890107192C89423630 @default.
• W2890107192 hasFunder F4320306082 @default.
• W2890107192 hasFunder F4320306137 @default.
• W2890107192 hasFunder F4320320671 @default.
• W2890107192 hasFunder F4320320672 @default.
• W2890107192 hasIssue "39" @default.
• W2890107192 hasLocation W28901071921 @default.
• W2890107192 hasLocation W28901071922 @default.
• W2890107192 hasLocation W28901071923 @default.
• W2890107192 hasLocation W28901071924 @default.
• W2890107192 hasOpenAccess W2890107192 @default.
• W2890107192 hasPrimaryLocation W28901071921 @default.
• W2890107192 hasRelatedWork W2001160858 @default.
• W2890107192 hasRelatedWork W2038745382 @default.
• W2890107192 hasRelatedWork W2533416995 @default.
• W2890107192 hasRelatedWork W2677838751 @default.
• W2890107192 hasRelatedWork W2749691721 @default.
• W2890107192 hasRelatedWork W2890107192 @default.
• W2890107192 hasRelatedWork W2952047223 @default.
• W2890107192 hasRelatedWork W2972094210 @default.
• W2890107192 hasRelatedWork W3029116816 @default.
• W2890107192 hasRelatedWork W4308058527 @default.
• W2890107192 hasVolume "115" @default.
• W2890107192 isParatext "false" @default.
• W2890107192 isRetracted "false" @default.
• W2890107192 magId "2890107192" @default.
• W2890107192 workType "article" @default.