FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890109603> ?p ?o ?g. }

• W2890109603 endingPage "500" @default.
• W2890109603 startingPage "491" @default.
• W2890109603 abstract "Metabolomics offers the opportunity to uncover endogenous biomarkers that can lead to metabolic pathways and networks and that underpin drug toxicity mechanisms. A novel protocol is presented and discussed that is applicable to drugs which generate urinary metabolites when administered to mice sensitive to its toxicity. The protocol would not apply to drugs that are not metabolized or eliminated by a different route. Separate stable isotope-labeled and unlabeled drug administration to mice is made together with collection of urines from control animals. Untargeted mass spectrometry-based metabolomic analysis of these three urine groups is conducted in addition to principal components analysis (PCA). In the case of unlabeled acetaminophen and [acetyl-2H3]acetaminophen, each given at a hepatotoxic dose (400 mg/kg i.p.) to the sensitive mouse strain (wild-type 129), the PCA loadings plot showed a distribution of ions in the shape of a fallen-Y with the deuterated metabolites in one arm and the paired nondeuterated metabolites in the other arm of the fallen-Y. Ions corresponding to the endogenous toxicity biomarkers sat in the mouth of the fallen-Y. This protocol represents an innovative means to separate endogenous biomarkers from drug metabolites, thereby aiding the identification of biomarkers of drug toxicity. For acetaminophen, increased hepatic oxidative stress, mitochondrial damage, Ca2+ signaling, heme catabolism, and saturation of glucuronidation, together with decreased fatty acid β-oxidation and cellular energy dysregulation were all implied from the discovered biomarkers. The protocol can be applied to other drugs and may now be translated to clinical studies." @default.
• W2890109603 created "2018-09-27" @default.
• W2890109603 creator A5067640436 @default.
• W2890109603 creator A5073190439 @default.
• W2890109603 creator A5085813496 @default.
• W2890109603 creator A5090549749 @default.
• W2890109603 date "2018-10-01" @default.
• W2890109603 modified "2023-09-28" @default.
• W2890109603 title "Mass isotopomer-guided decluttering of metabolomic data to visualize endogenous biomarkers of drug toxicity" @default.
• W2890109603 cites W147391422 @default.
• W2890109603 cites W1549912426 @default.
• W2890109603 cites W1560669295 @default.
• W2890109603 cites W1597285948 @default.
• W2890109603 cites W1906559125 @default.
• W2890109603 cites W1914762032 @default.
• W2890109603 cites W1964423187 @default.
• W2890109603 cites W1965321163 @default.
• W2890109603 cites W1968813633 @default.
• W2890109603 cites W1980736088 @default.
• W2890109603 cites W1982772252 @default.
• W2890109603 cites W1992243524 @default.
• W2890109603 cites W1994768228 @default.
• W2890109603 cites W2006248898 @default.
• W2890109603 cites W2017246842 @default.
• W2890109603 cites W2022147764 @default.
• W2890109603 cites W2026375486 @default.
• W2890109603 cites W2029257563 @default.
• W2890109603 cites W2033798327 @default.
• W2890109603 cites W2035398957 @default.
• W2890109603 cites W2040147755 @default.
• W2890109603 cites W2044992357 @default.
• W2890109603 cites W2045335969 @default.
• W2890109603 cites W2047223158 @default.
• W2890109603 cites W2054120770 @default.
• W2890109603 cites W2055923752 @default.
• W2890109603 cites W2059655597 @default.
• W2890109603 cites W2071580170 @default.
• W2890109603 cites W2077304657 @default.
• W2890109603 cites W2079350327 @default.
• W2890109603 cites W2082920045 @default.
• W2890109603 cites W2084375915 @default.
• W2890109603 cites W2086714780 @default.
• W2890109603 cites W2088876950 @default.
• W2890109603 cites W2092355725 @default.
• W2890109603 cites W2093277237 @default.
• W2890109603 cites W2095529373 @default.
• W2890109603 cites W2111792754 @default.
• W2890109603 cites W2113038192 @default.
• W2890109603 cites W2129314769 @default.
• W2890109603 cites W2130382164 @default.
• W2890109603 cites W2131572567 @default.
• W2890109603 cites W2136022660 @default.
• W2890109603 cites W2143873144 @default.
• W2890109603 cites W2147605431 @default.
• W2890109603 cites W2149657578 @default.
• W2890109603 cites W2163790438 @default.
• W2890109603 cites W2169958072 @default.
• W2890109603 cites W2183008024 @default.
• W2890109603 cites W2304702132 @default.
• W2890109603 cites W2341031032 @default.
• W2890109603 cites W2462514513 @default.
• W2890109603 cites W2495332292 @default.
• W2890109603 cites W2519211245 @default.
• W2890109603 cites W2560620714 @default.
• W2890109603 cites W2592430768 @default.
• W2890109603 cites W2614761965 @default.
• W2890109603 cites W2620881667 @default.
• W2890109603 cites W2737385463 @default.
• W2890109603 cites W2738663389 @default.
• W2890109603 cites W2764011553 @default.
• W2890109603 cites W2786710826 @default.
• W2890109603 cites W2805550741 @default.
• W2890109603 cites W2844741379 @default.
• W2890109603 cites W961595205 @default.
• W2890109603 doi "https://doi.org/10.1016/j.bcp.2018.09.022" @default.
• W2890109603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30243960" @default.
• W2890109603 hasPublicationYear "2018" @default.
• W2890109603 type Work @default.
• W2890109603 sameAs 2890109603 @default.
• W2890109603 citedByCount "9" @default.
• W2890109603 countsByYear W28901096032020 @default.
• W2890109603 countsByYear W28901096032021 @default.
• W2890109603 countsByYear W28901096032022 @default.
• W2890109603 countsByYear W28901096032023 @default.
• W2890109603 crossrefType "journal-article" @default.
• W2890109603 hasAuthorship W2890109603A5067640436 @default.
• W2890109603 hasAuthorship W2890109603A5073190439 @default.
• W2890109603 hasAuthorship W2890109603A5085813496 @default.
• W2890109603 hasAuthorship W2890109603A5090549749 @default.
• W2890109603 hasConcept C135870905 @default.
• W2890109603 hasConcept C16613235 @default.
• W2890109603 hasConcept C178790620 @default.
• W2890109603 hasConcept C181199279 @default.
• W2890109603 hasConcept C185592680 @default.
• W2890109603 hasConcept C21565614 @default.
• W2890109603 hasConcept C2777477808 @default.
• W2890109603 hasConcept C2778722691 @default.
• W2890109603 hasConcept C2779907587 @default.

• next