FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890112005> ?p ?o ?g. }

• W2890112005 abstract "Sight is a major sense for human and visual impairment profoundly affects quality of life, especially retinal degenerative diseases which are the leading cause of irreversible blindness worldwide. As for other neurodegenerative disorders, almost all retinal dystrophies are characterized by the specific loss of one or two cell types, such as retinal ganglion cells, photoreceptor cells, or retinal pigmented epithelial cells. This feature is a critical point when dealing with cell replacement strategies considering that the preservation of other cell types and retinal circuitry is a prerequisite. Retinal ganglion cells are particularly vulnerable to degenerative process and glaucoma, the most common optic neuropathy, is a frequent retinal dystrophy. Cell replacement has been proposed as a potential approach to take on the challenge of visual restoration, but its application to optic neuropathies is particularly challenging. Many obstacles need to be overcome before any clinical application. Beyond their survival and differentiation, engrafted cells have to reconnect with both upstream synaptic retinal cell partners and specific targets in the brain. To date, reconnection of retinal ganglion cells with distal central targets appears unrealistic since central nervous system is refractory to regenerative processes. Significant progress on the understanding of molecular mechanisms that prevent central nervous system regeneration offer hope to overcome this obstacle in the future. At the same time, emergence of reprogramming of human somatic cells into pluripotent stem cells has facilitated both the generation of new source of cells with therapeutic potential and the development of innovative methods for the generation of transplantable cells. In this review, we discuss the feasibility of stem cell-based strategies applied to retinal ganglion cells and optic nerve impairment. We present the different strategies for the generation, characterization and the delivery of transplantable retinal ganglion cells derived from pluripotent stem cells. The relevance of pluripotent stem cell-derived retinal organoid and retinal ganglion cells for disease modeling or drug screening will be also introduced in the context of optic neuropathies." @default.
• W2890112005 created "2018-09-27" @default.
• W2890112005 creator A5001520283 @default.
• W2890112005 creator A5016756958 @default.
• W2890112005 creator A5065963816 @default.
• W2890112005 date "2018-09-20" @default.
• W2890112005 modified "2023-10-16" @default.
• W2890112005 title "Pluripotent Stem Cell-Based Approaches to Explore and Treat Optic Neuropathies" @default.
• W2890112005 cites W1231432958 @default.
• W2890112005 cites W146281717 @default.
• W2890112005 cites W1483496013 @default.
• W2890112005 cites W1509287381 @default.
• W2890112005 cites W1509884519 @default.
• W2890112005 cites W1523693806 @default.
• W2890112005 cites W1555080212 @default.
• W2890112005 cites W1563169973 @default.
• W2890112005 cites W1596255224 @default.
• W2890112005 cites W1600830780 @default.
• W2890112005 cites W1608783464 @default.
• W2890112005 cites W1653914365 @default.
• W2890112005 cites W1872187949 @default.
• W2890112005 cites W1895408795 @default.
• W2890112005 cites W1898957235 @default.
• W2890112005 cites W1915110676 @default.
• W2890112005 cites W1917188074 @default.
• W2890112005 cites W1934209312 @default.
• W2890112005 cites W1963804798 @default.
• W2890112005 cites W1966089167 @default.
• W2890112005 cites W1967445833 @default.
• W2890112005 cites W1969811289 @default.
• W2890112005 cites W1970977410 @default.
• W2890112005 cites W1972343445 @default.
• W2890112005 cites W1973005952 @default.
• W2890112005 cites W1973029281 @default.
• W2890112005 cites W1974663075 @default.
• W2890112005 cites W1976200396 @default.
• W2890112005 cites W1979509436 @default.
• W2890112005 cites W1982606894 @default.
• W2890112005 cites W1982938145 @default.
• W2890112005 cites W1983128785 @default.
• W2890112005 cites W1983713659 @default.
• W2890112005 cites W1984567171 @default.
• W2890112005 cites W1986595047 @default.
• W2890112005 cites W1987035937 @default.
• W2890112005 cites W1988939522 @default.
• W2890112005 cites W1989324842 @default.
• W2890112005 cites W1990433739 @default.
• W2890112005 cites W1991536078 @default.
• W2890112005 cites W1991938466 @default.
• W2890112005 cites W1994009311 @default.
• W2890112005 cites W1994548430 @default.
• W2890112005 cites W1995545448 @default.
• W2890112005 cites W1998025788 @default.
• W2890112005 cites W2001030512 @default.
• W2890112005 cites W2001503236 @default.
• W2890112005 cites W2002385895 @default.
• W2890112005 cites W2003994112 @default.
• W2890112005 cites W2004538934 @default.
• W2890112005 cites W2005001826 @default.
• W2890112005 cites W2005626802 @default.
• W2890112005 cites W2006520238 @default.
• W2890112005 cites W2008607886 @default.
• W2890112005 cites W2011418014 @default.
• W2890112005 cites W2012363742 @default.
• W2890112005 cites W2014987484 @default.
• W2890112005 cites W2015162112 @default.
• W2890112005 cites W2015966587 @default.
• W2890112005 cites W2016397514 @default.
• W2890112005 cites W2016722318 @default.
• W2890112005 cites W2017030433 @default.
• W2890112005 cites W2017347785 @default.
• W2890112005 cites W2017350075 @default.
• W2890112005 cites W2018165416 @default.
• W2890112005 cites W2018286352 @default.
• W2890112005 cites W2018985172 @default.
• W2890112005 cites W2019116868 @default.
• W2890112005 cites W2021814062 @default.
• W2890112005 cites W2023583278 @default.
• W2890112005 cites W2026770509 @default.
• W2890112005 cites W2030648800 @default.
• W2890112005 cites W2031050651 @default.
• W2890112005 cites W2031166546 @default.
• W2890112005 cites W2031173953 @default.
• W2890112005 cites W2036505824 @default.
• W2890112005 cites W2037390777 @default.
• W2890112005 cites W2039798198 @default.
• W2890112005 cites W2040250052 @default.
• W2890112005 cites W2040434386 @default.
• W2890112005 cites W2041302930 @default.
• W2890112005 cites W2041742383 @default.
• W2890112005 cites W2042727933 @default.
• W2890112005 cites W2044858838 @default.
• W2890112005 cites W2047392405 @default.
• W2890112005 cites W2049279317 @default.
• W2890112005 cites W2049677403 @default.
• W2890112005 cites W2050065221 @default.
• W2890112005 cites W2050330067 @default.
• W2890112005 cites W2054645266 @default.
• W2890112005 cites W2054750473 @default.
• W2890112005 cites W2056117418 @default.

• next