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- W2890112377 abstract "Abstract Assessing target occupancy is critical for establishing proof-of-mechanism for novel inhibitors and to determine whether robust target inhibition can be achieved at tolerated doses. This is challenging in the clinic using conventional methods due to the need for untreated controls. We describe a new mass spectrometry approach to quantitatively assess target occupancy for covalent inhibitors that does not require untreated controls, and apply the method to the KRAS G12C inhibitor ARS-1620." @default.
- W2890112377 created "2018-09-27" @default.
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- W2890112377 date "2018-09-25" @default.
- W2890112377 modified "2023-10-18" @default.
- W2890112377 title "An Internally Controlled Quantitative Target Occupancy Assay for Covalent Inhibitors" @default.
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- W2890112377 doi "https://doi.org/10.1038/s41598-018-32683-w" @default.
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