Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890112656> ?p ?o ?g. }
- W2890112656 abstract "Coxsackievirus A10 (CVA10) recently emerged as a major pathogen of hand, foot, and mouth disease and herpangina in children worldwide, and lack of a vaccine or a cure against CVA10 infections has made therapeutic antibody identification a public health priority. By targeting a local isolate, CVA10-FJ-01, we obtained a potent antibody, 2G8, against all three capsid forms of CVA10. We show that 2G8 exhibited both 100% preventive and 100% therapeutic efficacy against CVA10 infection in mice. Comparisons of the near-atomic cryo-electron microscopy structures of the three forms of CVA10 capsid and their complexes with 2G8 Fab reveal that a single Fab binds a border region across the three capsid proteins (VP1 to VP3) and explain 2G8's remarkable cross-reactivities against all three capsid forms. The atomic structures of this first neutralizing antibody of CVA10 should inform strategies for designing vaccines and therapeutics against CVA10 infections." @default.
- W2890112656 created "2018-09-27" @default.
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- W2890112656 date "2018-09-07" @default.
- W2890112656 modified "2023-10-10" @default.
- W2890112656 title "Discovery and structural characterization of a therapeutic antibody against coxsackievirus A10" @default.
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- W2890112656 doi "https://doi.org/10.1126/sciadv.aat7459" @default.
- W2890112656 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6155056" @default.
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- W2890112656 hasPublicationYear "2018" @default.
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