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• W2890119562 abstract "The characteristic fold of a protein is the decisive factor for its biological function. However, small structural changes to amino acids can also affect their function, for example in the case of post-translational modification (PTM). Many different types of PTMs are known, but for some, including chlorination, studies elucidating their importance are limited. A recent study revealed that the YjgF/YER057c/UK114 family (YjgF family) member RidA from Escherichia coli shows chaperone activity after chlorination. Thus, to identify the functional and structural differences of RidA upon chlorination, we studied an RidA homolog from Staphylococcus aureus: YabJ. The overall structure of S. aureus YabJ was similar to other members of the YjgF family, showing deep pockets on its surface, and the residues composing the pockets were well conserved. S. aureus YabJ was highly stable after chlorination, and the chlorinated state is reversible by treatment with DTT. However, it shows no chaperone activity after chlorination. Instead, YabJ from S. aureus shows chlorination-induced ribonuclease activity, and the activity is diminished after subsequent reduction. Even though the yabJ genes from Staphylococcus and Bacillus are clustered with regulators that are expected to code nucleic acid-interacting proteins, the nucleic acid-related activity of bacterial RidA has not been identified before. From our study, we revealed the structure and function of S. aureus YabJ as a novel chlorination-activated ribonuclease. The present study will contribute to an in-depth understanding of chlorination as a PTM." @default.
• W2890119562 created "2018-09-27" @default.
• W2890119562 creator A5023660159 @default.
• W2890119562 creator A5041633278 @default.
• W2890119562 creator A5086369397 @default.
• W2890119562 date "2018-10-17" @default.
• W2890119562 modified "2023-09-27" @default.
• W2890119562 title "A novel chlorination-induced ribonuclease YabJ from <i>Staphylococcus aureus</i>" @default.
• W2890119562 cites W1508587432 @default.
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• W2890119562 cites W1746790713 @default.
• W2890119562 cites W178521243 @default.
• W2890119562 cites W1887341968 @default.
• W2890119562 cites W1971030848 @default.
• W2890119562 cites W1974273168 @default.
• W2890119562 cites W1975459052 @default.
• W2890119562 cites W1979508554 @default.
• W2890119562 cites W1984658022 @default.
• W2890119562 cites W1985468934 @default.
• W2890119562 cites W1987053691 @default.
• W2890119562 cites W1987363291 @default.
• W2890119562 cites W1987434147 @default.
• W2890119562 cites W1992545031 @default.
• W2890119562 cites W1993094173 @default.
• W2890119562 cites W1994431202 @default.
• W2890119562 cites W1996607909 @default.
• W2890119562 cites W1999469282 @default.
• W2890119562 cites W2001326517 @default.
• W2890119562 cites W2003878905 @default.
• W2890119562 cites W2004175162 @default.
• W2890119562 cites W2005066584 @default.
• W2890119562 cites W2010182567 @default.
• W2890119562 cites W2017393660 @default.
• W2890119562 cites W2017589495 @default.
• W2890119562 cites W2018289835 @default.
• W2890119562 cites W2025938842 @default.
• W2890119562 cites W2030517878 @default.
• W2890119562 cites W2032327494 @default.
• W2890119562 cites W2035503835 @default.
• W2890119562 cites W2038840577 @default.
• W2890119562 cites W2039670099 @default.
• W2890119562 cites W2040447429 @default.
• W2890119562 cites W2045140968 @default.
• W2890119562 cites W2054395586 @default.
• W2890119562 cites W2055848875 @default.
• W2890119562 cites W2057616220 @default.
• W2890119562 cites W2059149560 @default.
• W2890119562 cites W2061002477 @default.
• W2890119562 cites W2070505577 @default.
• W2890119562 cites W2072284792 @default.
• W2890119562 cites W2074731332 @default.
• W2890119562 cites W2074978715 @default.
• W2890119562 cites W2084198524 @default.
• W2890119562 cites W2091400130 @default.
• W2890119562 cites W2092611950 @default.
• W2890119562 cites W2094476648 @default.
• W2890119562 cites W2098336516 @default.
• W2890119562 cites W2099861711 @default.
• W2890119562 cites W2100837269 @default.
• W2890119562 cites W2103056313 @default.
• W2890119562 cites W2103214923 @default.
• W2890119562 cites W2108921801 @default.
• W2890119562 cites W2123440974 @default.
• W2890119562 cites W2132629607 @default.
• W2890119562 cites W2132684936 @default.
• W2890119562 cites W2133827033 @default.
• W2890119562 cites W2140715870 @default.
• W2890119562 cites W2144081223 @default.
• W2890119562 cites W2144121476 @default.
• W2890119562 cites W2146080841 @default.
• W2890119562 cites W2154197653 @default.
• W2890119562 cites W2156944078 @default.
• W2890119562 cites W2159211495 @default.
• W2890119562 cites W2165100507 @default.
• W2890119562 cites W2168974130 @default.
• W2890119562 cites W2169173043 @default.
• W2890119562 cites W2172123465 @default.
• W2890119562 cites W2180229411 @default.
• W2890119562 cites W2237152926 @default.
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• W2890119562 doi "https://doi.org/10.1042/bsr20180768" @default.
• W2890119562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6435465" @default.
• W2890119562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30201692" @default.
• W2890119562 hasPublicationYear "2018" @default.
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