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- W2890120056 abstract "Response to targeted therapies is limited by the activation or inhibition of feedback loops. Here we report the ubiquitin specific peptidase 28/F-box WD repeat-containing protein 7 (USP28/FBW7) complex functions as a negative regulator of mitogen-activated protein kinase (MAPK) pathway by targeting v-raf murine sarcoma viral oncogene homolog B (BRAF) for degradation, a process which is lost in a large proportion of BRAF mutant melanoma patients, resulting in resistance to BRAF inhibitor therapies." @default.
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- W2890120056 date "2018-09-03" @default.
- W2890120056 modified "2023-10-03" @default.
- W2890120056 title "Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma" @default.
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- W2890120056 doi "https://doi.org/10.1080/23723556.2018.1497862" @default.
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