FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890120322> ?p ?o ?g. }

• W2890120322 abstract "Type 2 diabetes mellitus (T2D), rapidly increasing to epidemic proportions, globally escalates cardiovascular disease risk. Although intensive interventions and comprehensive management of environmental risks factors for T2D are associated with reduced cardiovascular disease, such approaches are limited for individuals with high genetic T2D risk. In this study we investigated possible associations of ACE2 polymorphisms and cardiovascular risks in Uygur patients with T2D. 275 Uygur T2D patients and 272 non-diabetic Uygur individuals were enrolled as study participants. 14 ACE2 polymorphisms were genotyped by Matrix-assisted laser desorption ionization time-of-flight mass spectrometry. ACE2 SNP rs1978124, rs2048683, rs2074192, rs233575, rs4240157, rs4646156, rs4646188 and rs879922 were associated with T2D (all P < 0.05). The 8 diabetic risk related ACE2 SNPs were further associated with diabetic related cardiovascular complications or events but exhibited heterogeneity as fellows: firstly, almost all diabetic risk related ACE2 SNPs (all P < 0.05) were associated with increased SBP except rs1978124 and rs2074192, while rs2074192, rs4646188 and rs879922 were associated elevated DBP (all P < 0.05). Secondly, SNP rs4646188 was not correlated with any type of dyslipidemia (TRIG, HDL-C, LDL-C or CHOL), and the other 7 diabetic risk related loci were at least correlated with one type of dyslipidemia (all P < 0.05). In particular, rs879922 were simultaneously correlated with four type of dyslipidemia (all P < 0.05). Thirdly, ACE2 SNP rs2074192 and rs879922 were associated with carotid arteriosclerosis stenosis (CAS) ≥ 50% (both P < 0.05). Fourthly, ACE2 SNP rs2074192, rs4240157, rs4646188 and 879922 were associated with increased MAU (all P < 0.05). In addition, ACE2 SNP rs2048683, rs4240157, rs4646156, rs4646188 and rs879922 were linked to heavier LVMI (all P < 0.05), but only rs4240157, rs4646156 and rs4646188 were associated with lower LVEF (all P < 0.05). ACE2 SNP rs879922 may be a common genetic loci and optimal genetic susceptibility marker for T2D and T2D related cardiovascular risks in Uygurs." @default.
• W2890120322 created "2018-09-27" @default.
• W2890120322 creator A5015069162 @default.
• W2890120322 creator A5030131824 @default.
• W2890120322 creator A5036399586 @default.
• W2890120322 creator A5043219536 @default.
• W2890120322 creator A5044650830 @default.
• W2890120322 creator A5047697862 @default.
• W2890120322 creator A5047916176 @default.
• W2890120322 creator A5054121557 @default.
• W2890120322 creator A5068242622 @default.
• W2890120322 date "2018-09-18" @default.
• W2890120322 modified "2023-10-18" @default.
• W2890120322 title "ACE2 polymorphisms associated with cardiovascular risk in Uygurs with type 2 diabetes mellitus" @default.
• W2890120322 cites W1581896140 @default.
• W2890120322 cites W1766960367 @default.
• W2890120322 cites W182112830 @default.
• W2890120322 cites W1966328542 @default.
• W2890120322 cites W1968181432 @default.
• W2890120322 cites W1979488003 @default.
• W2890120322 cites W1981694088 @default.
• W2890120322 cites W1991838665 @default.
• W2890120322 cites W2006697646 @default.
• W2890120322 cites W2025072503 @default.
• W2890120322 cites W2047955620 @default.
• W2890120322 cites W2053898563 @default.
• W2890120322 cites W2054815225 @default.
• W2890120322 cites W2064837935 @default.
• W2890120322 cites W2104103470 @default.
• W2890120322 cites W2108657492 @default.
• W2890120322 cites W2109740270 @default.
• W2890120322 cites W2116047107 @default.
• W2890120322 cites W2124624517 @default.
• W2890120322 cites W2125065061 @default.
• W2890120322 cites W2140415161 @default.
• W2890120322 cites W2145487661 @default.
• W2890120322 cites W2168261002 @default.
• W2890120322 cites W2170069518 @default.
• W2890120322 cites W2216924858 @default.
• W2890120322 cites W2227548958 @default.
• W2890120322 cites W2255580400 @default.
• W2890120322 cites W2346808375 @default.
• W2890120322 cites W2409181047 @default.
• W2890120322 cites W2412117889 @default.
• W2890120322 cites W2441391782 @default.
• W2890120322 cites W2462883443 @default.
• W2890120322 cites W2503450476 @default.
• W2890120322 cites W2508716146 @default.
• W2890120322 cites W2519497864 @default.
• W2890120322 cites W2520709760 @default.
• W2890120322 cites W2558617381 @default.
• W2890120322 cites W2569189597 @default.
• W2890120322 cites W2580928085 @default.
• W2890120322 cites W2586320696 @default.
• W2890120322 cites W2606251550 @default.
• W2890120322 cites W2609543937 @default.
• W2890120322 cites W2729472155 @default.
• W2890120322 cites W2731349674 @default.
• W2890120322 cites W2755474558 @default.
• W2890120322 cites W2777213061 @default.
• W2890120322 cites W2777641772 @default.
• W2890120322 cites W2778032307 @default.
• W2890120322 cites W2788267568 @default.
• W2890120322 cites W2882972976 @default.
• W2890120322 cites W2888814360 @default.
• W2890120322 cites W2916481903 @default.
• W2890120322 cites W4249896096 @default.
• W2890120322 doi "https://doi.org/10.1186/s12933-018-0771-3" @default.
• W2890120322 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6142339" @default.
• W2890120322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30227878" @default.
• W2890120322 hasPublicationYear "2018" @default.
• W2890120322 type Work @default.
• W2890120322 sameAs 2890120322 @default.
• W2890120322 citedByCount "67" @default.
• W2890120322 countsByYear W28901203222019 @default.
• W2890120322 countsByYear W28901203222020 @default.
• W2890120322 countsByYear W28901203222021 @default.
• W2890120322 countsByYear W28901203222022 @default.
• W2890120322 countsByYear W28901203222023 @default.
• W2890120322 crossrefType "journal-article" @default.
• W2890120322 hasAuthorship W2890120322A5015069162 @default.
• W2890120322 hasAuthorship W2890120322A5030131824 @default.
• W2890120322 hasAuthorship W2890120322A5036399586 @default.
• W2890120322 hasAuthorship W2890120322A5043219536 @default.
• W2890120322 hasAuthorship W2890120322A5044650830 @default.
• W2890120322 hasAuthorship W2890120322A5047697862 @default.
• W2890120322 hasAuthorship W2890120322A5047916176 @default.
• W2890120322 hasAuthorship W2890120322A5054121557 @default.
• W2890120322 hasAuthorship W2890120322A5068242622 @default.
• W2890120322 hasBestOaLocation W28901203221 @default.
• W2890120322 hasConcept C104317684 @default.
• W2890120322 hasConcept C126322002 @default.
• W2890120322 hasConcept C134018914 @default.
• W2890120322 hasConcept C135763542 @default.
• W2890120322 hasConcept C139275648 @default.
• W2890120322 hasConcept C153209595 @default.
• W2890120322 hasConcept C2777180221 @default.
• W2890120322 hasConcept C2778096610 @default.
• W2890120322 hasConcept C2779134260 @default.
• W2890120322 hasConcept C2910068830 @default.

• next