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• W2890122780 abstract "Cotranslational folding (CTF) is a fundamental molecular process that ensures efficient protein biosynthesis and minimizes the formation of misfolded states. However, the complexity of this process makes it extremely challenging to obtain structural characterizations of CTF pathways. Here, we correlate observations of translationally arrested nascent chains with those of a systematic C-terminal truncation strategy. We create a detailed description of chain length-dependent free energy landscapes associated with folding of the FLN5 filamin domain, in isolation and on the ribosome, and thus, quantify a substantial destabilization of the native structure on the ribosome. We identify and characterize two folding intermediates formed in isolation, including a partially folded intermediate associated with the isomerization of a conserved cis proline residue. The slow folding associated with this process raises the prospect that neighboring unfolded domains might accumulate and misfold during biosynthesis. We develop a simple model to quantify the risk of misfolding in this situation and show that catalysis of folding by peptidyl-prolyl isomerases is sufficient to eliminate this hazard." @default.
• W2890122780 created "2018-09-27" @default.
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• W2890122780 date "2018-09-10" @default.
• W2890122780 modified "2023-10-18" @default.
• W2890122780 title "Systematic mapping of free energy landscapes of a growing filamin domain during biosynthesis" @default.
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• W2890122780 doi "https://doi.org/10.1073/pnas.1716252115" @default.
• W2890122780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6166796" @default.
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