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• W2890122887 abstract "Anthracyclines rank among the most efficacious anticancer medications. However, their clinical utility and oncologic efficacy are severely compromised by the cardiotoxicity risk facing the early-diagnosis difficulty and their unclear molecular mechanism. Herein, a two-photon-excitable and near-infrared-emissive fluorescent probe, TPNIR-FP, was fabricated and endowed with extraordinary specificity and sensitivity and a rapid response toward peroxynitrite (ONOO–), as well as mitochondria-targeting ability. With the aid of TPNIR-FP, we demonstrate that mitochondrial ONOO– is upregulated in the early stage and contributes to the onset and progression of anthracycline cardiotoxicity in cardiomyocyte and mouse models; therefore, it represents an early biomarker to predict subclinical cardiotoxicity induced by drug challenge. Furthermore, TPNIR-FP is proved to be a robust imaging tool to provide critical insights into drug-induced cardiotoxicity and other ONOO–-related pathophysiological processes." @default.
• W2890122887 created "2018-09-27" @default.
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• W2890122887 date "2018-09-10" @default.
• W2890122887 modified "2023-10-18" @default.
• W2890122887 title "Mitochondrial Peroxynitrite Mediation of Anthracycline-Induced Cardiotoxicity as Visualized by a Two-Photon Near-Infrared Fluorescent Probe" @default.
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• W2890122887 doi "https://doi.org/10.1021/acs.analchem.8b03207" @default.
• W2890122887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30196694" @default.
• W2890122887 hasPublicationYear "2018" @default.
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