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- W2890123251 abstract "The gut microbiome, a diverse microbial community in the gastrointestinal tract, plays a pivotal role in the maintenance of health. The gut microbiome metabolizes dietary and host-derived molecules to produce bioactive metabolites, which have a wide array of effects on host metabolism and immunity. 'Dysbiosis' of the gut microbiome, commonly considered as perturbation of microbiome diversity and composition, has been associated with intestinal and extra-intestinal diseases, including nonalcoholic fatty liver disease (NAFLD). A number of endogenous and exogenous factors, such as nutritional intake and xenobiotic exposure, can alter the gut microbiome. We will review the evolving methods for studying the gut microbiome and how these profiling techniques have been utilized to further our understanding of the gut microbial community composition and functional potential in the clinical spectrum of NAFLD. We will highlight microbiome-host interactions that may contribute to the pathogenesis of NAFLD, with a primary focus on mechanisms related to the metabolic output of the gut microbiome. Finally, we will discuss potential therapeutic implications of the gut microbiome in NAFLD." @default.
- W2890123251 created "2018-09-27" @default.
- W2890123251 creator A5028383260 @default.
- W2890123251 creator A5034333660 @default.
- W2890123251 creator A5052059601 @default.
- W2890123251 date "2019-01-01" @default.
- W2890123251 modified "2023-09-29" @default.
- W2890123251 title "Emerging Role of the Gut Microbiome in Nonalcoholic Fatty Liver Disease: From Composition to Function" @default.
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- W2890123251 doi "https://doi.org/10.1016/j.cgh.2018.08.065" @default.
- W2890123251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6314895" @default.
- W2890123251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30196156" @default.
- W2890123251 hasPublicationYear "2019" @default.
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