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- W2890127569 endingPage "17" @default.
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- W2890127569 abstract "Recent approvals of several blockers of the cytotoxic T lymphocyte (CTL)-associated antigen-4—CD80/CD86 pathway (Ipilimumab/Yervoy) and the PD-1—PD-L1/PD-L2 pathway, such as nivolumab (Opdivo), pembrolizumab (Keytruda), or atezolizumab (Tecentriq), ushered immune checkpoint (IC) inhibitors (ICIs) as the key component of advanced cancer treatment. Checkpoint blockers can induce complete and long lasting responses in high proportion of patients with advanced melanoma and other cancers. However, even in melanoma, most patients show only limited or transient response, while such common cancers as breast, prostate, or colon cancer respond only sporadically. Three groups of factors relevant to the biology of cancer cells and local tumor microenvironment (TME) predict the clinical benefit of ICIs in individual patients: the mutation load of cancer cells, local density of cytotoxic T lymphocytes (CTLs) in the TME, and local expression of PD-1 and PD-L1.1, 2, 3 Within this chapter, we discuss the mechanism of action ICIs, factors affecting their antitumor effectiveness, and emerging strategies to enhance their therapeutic benefit." @default.
- W2890127569 created "2018-09-27" @default.
- W2890127569 creator A5057788524 @default.
- W2890127569 creator A5075501671 @default.
- W2890127569 date "2019-01-01" @default.
- W2890127569 modified "2023-09-26" @default.
- W2890127569 title "Immune Checkpoint Inhibitors" @default.
- W2890127569 cites W1480698358 @default.
- W2890127569 cites W1498093713 @default.
- W2890127569 cites W1498931318 @default.
- W2890127569 cites W1533335323 @default.
- W2890127569 cites W1538902372 @default.
- W2890127569 cites W1568317937 @default.
- W2890127569 cites W1571009899 @default.
- W2890127569 cites W1749548564 @default.
- W2890127569 cites W1809627231 @default.
- W2890127569 cites W1817318311 @default.
- W2890127569 cites W1856892620 @default.
- W2890127569 cites W1880594232 @default.
- W2890127569 cites W1885439970 @default.
- W2890127569 cites W1889753107 @default.
- W2890127569 cites W1908442436 @default.
- W2890127569 cites W1912124796 @default.
- W2890127569 cites W1933761723 @default.
- W2890127569 cites W1940241680 @default.
- W2890127569 cites W1955548161 @default.
- W2890127569 cites W1963861811 @default.
- W2890127569 cites W1965184762 @default.
- W2890127569 cites W1972073222 @default.
- W2890127569 cites W1973488436 @default.
- W2890127569 cites W1975352805 @default.
- W2890127569 cites W1977521348 @default.
- W2890127569 cites W1977818265 @default.
- W2890127569 cites W1980137951 @default.
- W2890127569 cites W1982969810 @default.
- W2890127569 cites W1983838712 @default.
- W2890127569 cites W1984198270 @default.
- W2890127569 cites W1984642649 @default.
- W2890127569 cites W1985532701 @default.
- W2890127569 cites W1988361291 @default.
- W2890127569 cites W1992699637 @default.
- W2890127569 cites W1993127492 @default.
- W2890127569 cites W1993596892 @default.
- W2890127569 cites W1996830477 @default.
- W2890127569 cites W2000609012 @default.
- W2890127569 cites W2001131198 @default.
- W2890127569 cites W2002293894 @default.
- W2890127569 cites W2002879831 @default.
- W2890127569 cites W2003579048 @default.
- W2890127569 cites W2004896918 @default.
- W2890127569 cites W2005158904 @default.
- W2890127569 cites W2007427978 @default.
- W2890127569 cites W2009124646 @default.
- W2890127569 cites W2009423208 @default.
- W2890127569 cites W2010121426 @default.
- W2890127569 cites W2011826559 @default.
- W2890127569 cites W2013090484 @default.
- W2890127569 cites W2016983859 @default.
- W2890127569 cites W2018192635 @default.
- W2890127569 cites W2021065674 @default.
- W2890127569 cites W2022580424 @default.
- W2890127569 cites W2028240889 @default.
- W2890127569 cites W2028376975 @default.
- W2890127569 cites W2035252444 @default.
- W2890127569 cites W2035562653 @default.
- W2890127569 cites W2036806228 @default.
- W2890127569 cites W2036958461 @default.
- W2890127569 cites W2038914273 @default.
- W2890127569 cites W2039072654 @default.
- W2890127569 cites W2039123767 @default.
- W2890127569 cites W2040793402 @default.
- W2890127569 cites W2043398751 @default.
- W2890127569 cites W2043843121 @default.
- W2890127569 cites W2047502920 @default.
- W2890127569 cites W2049491375 @default.
- W2890127569 cites W2049553585 @default.
- W2890127569 cites W2050457398 @default.
- W2890127569 cites W2050689883 @default.
- W2890127569 cites W2051083170 @default.
- W2890127569 cites W2053353274 @default.
- W2890127569 cites W2053366731 @default.
- W2890127569 cites W2053627244 @default.
- W2890127569 cites W2056535502 @default.
- W2890127569 cites W2057670039 @default.
- W2890127569 cites W2057968168 @default.
- W2890127569 cites W2058820448 @default.
- W2890127569 cites W2061817584 @default.
- W2890127569 cites W2063452120 @default.
- W2890127569 cites W2065202184 @default.
- W2890127569 cites W2066002010 @default.
- W2890127569 cites W2066671159 @default.
- W2890127569 cites W2069220906 @default.
- W2890127569 cites W2070631889 @default.
- W2890127569 cites W2071105396 @default.
- W2890127569 cites W2072448714 @default.
- W2890127569 cites W2074699765 @default.
- W2890127569 cites W2079936875 @default.
- W2890127569 cites W2081187505 @default.