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- W2890130855 abstract "Carnosine (β-alanyl-L-histidine) is synthesized in the olfactory system, has antioxidant activity as a scavenger of free radicals and has been reported to have neuroprotective action in diseases which have been attributed to oxidative damage. In neurodegenerative disorders, such as Parkinson's and Alzheimer's diseases, impairment of olfactory function has been described. Vanadium derivatives are environmental pollutants, and its toxicity has been associated with oxidative stress. Vanadium toxicity on the olfactory bulb was reported previously. This study investigates the neuroprotective effect of carnosine on the olfactory bulb in a mice model of vanadium inhalation. Male mice were divided into four groups: vanadium pentoxide (V2 O5 ) [0.02 mol/L] inhalation for one hour twice a week; V2 O5 inhalation plus 1 mg/kg of carnosine administered daily; carnosine only, and the control group that inhaled saline. The olfactory function was evaluated using the odorant test. Animals were sacrificed four weeks after exposure. The olfactory bulbs were dissected and processed using the rapid Golgi method; cytological and ultrastructural analysis was performed and malondialdehyde (MDA) concentrations were measured. The results showed evidence of olfactory dysfunction caused by vanadium exposure and also an increase in MDA levels, loss of dendritic spines and necrotic neuronal death in the granule cells. But, in contrast, vanadium-exposed mice treated with carnosine showed an increase in dendritic spines and a decrease in neuronal death and in MDA levels when compared with the group exposed to vanadium without carnosine. These results suggest that dendritic spine loss and ultrastructural alterations in the granule cells induced by vanadium are mediated by oxidative stress and that carnosine may modulate the neurotoxic vanadium action, improving the olfactory function." @default.
- W2890130855 created "2018-09-27" @default.
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- W2890130855 date "2018-08-01" @default.
- W2890130855 modified "2023-10-18" @default.
- W2890130855 title "Neuroprotective effect of carnosine in the olfactory bulb after vanadium inhalation in a mouse model" @default.
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- W2890130855 doi "https://doi.org/10.1111/iep.12285" @default.
- W2890130855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6157302" @default.
- W2890130855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30198103" @default.
- W2890130855 hasPublicationYear "2018" @default.
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