Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890131010> ?p ?o ?g. }
- W2890131010 abstract "Abstract The successful implementation of synthetic biology for chemicals biosynthesis relies on the availability of large libraries of well-characterized enzymatic building blocks. Here we present a scalable pipeline that applies the methodology of synthetic biology itself to bootstrap the creation of such a library. By designing and building a cytochrome P450 enzyme collection and testing it in a custom-made untargeted GC/MS-metabolomics-based approach, we were able to rapidly create and characterize a comprehensive enzyme library for the controlled oxyfunctionalisation of terpene scaffolds with a wide range of activities and selectivities towards several monoterpenes. This novel resource can now be used to access the extensive chemical diversity of terpenoids by pathway engineering and the assembly of biocatalytic cascades to subsequently produce libraries of oxygenated terpenoids and their derivatives for diverse applications, including drug discovery." @default.
- W2890131010 created "2018-09-27" @default.
- W2890131010 creator A5015209135 @default.
- W2890131010 creator A5018115979 @default.
- W2890131010 creator A5058612126 @default.
- W2890131010 creator A5066686497 @default.
- W2890131010 creator A5083776365 @default.
- W2890131010 date "2018-09-26" @default.
- W2890131010 modified "2023-10-17" @default.
- W2890131010 title "A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes" @default.
- W2890131010 cites W1532212858 @default.
- W2890131010 cites W1611854178 @default.
- W2890131010 cites W1867574205 @default.
- W2890131010 cites W1966728747 @default.
- W2890131010 cites W1973469745 @default.
- W2890131010 cites W1975012493 @default.
- W2890131010 cites W1981198397 @default.
- W2890131010 cites W1985152937 @default.
- W2890131010 cites W2014177423 @default.
- W2890131010 cites W2016652826 @default.
- W2890131010 cites W2017395349 @default.
- W2890131010 cites W2025190990 @default.
- W2890131010 cites W2027974246 @default.
- W2890131010 cites W2041963701 @default.
- W2890131010 cites W2042673218 @default.
- W2890131010 cites W2057805674 @default.
- W2890131010 cites W2060406819 @default.
- W2890131010 cites W2071861224 @default.
- W2890131010 cites W2077188424 @default.
- W2890131010 cites W2081465448 @default.
- W2890131010 cites W2138422824 @default.
- W2890131010 cites W2139185863 @default.
- W2890131010 cites W2144002130 @default.
- W2890131010 cites W2146103026 @default.
- W2890131010 cites W2147640354 @default.
- W2890131010 cites W2155189293 @default.
- W2890131010 cites W2157875225 @default.
- W2890131010 cites W2158120631 @default.
- W2890131010 cites W2163685659 @default.
- W2890131010 cites W2176429769 @default.
- W2890131010 cites W2267214493 @default.
- W2890131010 cites W2296876951 @default.
- W2890131010 cites W2464602309 @default.
- W2890131010 cites W2509142766 @default.
- W2890131010 cites W2543006537 @default.
- W2890131010 cites W2563213715 @default.
- W2890131010 cites W2574601093 @default.
- W2890131010 cites W2591221283 @default.
- W2890131010 cites W2768601698 @default.
- W2890131010 cites W2768881190 @default.
- W2890131010 cites W2785199231 @default.
- W2890131010 cites W2807341474 @default.
- W2890131010 cites W4234428106 @default.
- W2890131010 doi "https://doi.org/10.1038/s41598-018-32816-1" @default.
- W2890131010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6158249" @default.
- W2890131010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30258114" @default.
- W2890131010 hasPublicationYear "2018" @default.
- W2890131010 type Work @default.
- W2890131010 sameAs 2890131010 @default.
- W2890131010 citedByCount "24" @default.
- W2890131010 countsByYear W28901310102018 @default.
- W2890131010 countsByYear W28901310102019 @default.
- W2890131010 countsByYear W28901310102020 @default.
- W2890131010 countsByYear W28901310102021 @default.
- W2890131010 countsByYear W28901310102022 @default.
- W2890131010 countsByYear W28901310102023 @default.
- W2890131010 crossrefType "journal-article" @default.
- W2890131010 hasAuthorship W2890131010A5015209135 @default.
- W2890131010 hasAuthorship W2890131010A5018115979 @default.
- W2890131010 hasAuthorship W2890131010A5058612126 @default.
- W2890131010 hasAuthorship W2890131010A5066686497 @default.
- W2890131010 hasAuthorship W2890131010A5083776365 @default.
- W2890131010 hasBestOaLocation W28901310101 @default.
- W2890131010 hasConcept C127413603 @default.
- W2890131010 hasConcept C183696295 @default.
- W2890131010 hasConcept C185592680 @default.
- W2890131010 hasConcept C191908910 @default.
- W2890131010 hasConcept C199360897 @default.
- W2890131010 hasConcept C206103511 @default.
- W2890131010 hasConcept C2777655017 @default.
- W2890131010 hasConcept C41008148 @default.
- W2890131010 hasConcept C43521106 @default.
- W2890131010 hasConcept C44937612 @default.
- W2890131010 hasConcept C48044578 @default.
- W2890131010 hasConcept C55493867 @default.
- W2890131010 hasConcept C70721500 @default.
- W2890131010 hasConcept C74187038 @default.
- W2890131010 hasConcept C77088390 @default.
- W2890131010 hasConcept C86803240 @default.
- W2890131010 hasConceptScore W2890131010C127413603 @default.
- W2890131010 hasConceptScore W2890131010C183696295 @default.
- W2890131010 hasConceptScore W2890131010C185592680 @default.
- W2890131010 hasConceptScore W2890131010C191908910 @default.
- W2890131010 hasConceptScore W2890131010C199360897 @default.
- W2890131010 hasConceptScore W2890131010C206103511 @default.
- W2890131010 hasConceptScore W2890131010C2777655017 @default.
- W2890131010 hasConceptScore W2890131010C41008148 @default.
- W2890131010 hasConceptScore W2890131010C43521106 @default.
- W2890131010 hasConceptScore W2890131010C44937612 @default.
- W2890131010 hasConceptScore W2890131010C48044578 @default.