Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890131088> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2890131088 endingPage "1995" @default.
- W2890131088 startingPage "1991" @default.
- W2890131088 abstract "The high-affinity IgE receptor complex plays an essential part in allergic responses and involved in downstream signaling, released inflammatory mediators that cause allergic responses. The transmembrane region of the high-affinity IgE has a conserved motif (LFAVDTGL) where a polar aspartate (D194) is important for the ligand binding. This modeling study proposes novel potential binding sites between high affinity immunoglobulin E receptor α subunit (FcεRIα) and FcRγ and as a consequence, we propose a new model of FcεRIα and FcRγ interaction (T194) which can mediate downstream signaling in allergic response. The docking of FcRγ with wild-type (D194) and mutant human high affinity immunoglobulin E receptor α subunit (D194T, D194I, D194L, D194A, D194V, D194E, D194S and D194R) has been performed on Autodock Vina. This modeling study is based on lab data obtained by carrying out site-directed mutagenesis done at residue D194 of FcεRIα to assess its functional importance for the mediation of intracellular signal cascade. HuFcεRIα D194 residue was replaced with threonine, leucine, serine, arginine, alanine, asparagine and glutamic acid. FcRγ docking on mutated huFcεRIα (D194T) indicated a new site of interaction and emphasizes the significance of the charge and size of an amino acid at position 194 in huFcεRIα subunit. Amino acids D & T at position 194 are important for cell surface localization, interactions, distribution and downstream signaling of IgE receptor subunit. These proposed models may herald in better therapeutic interventions to combat unfavorably allergic diseases." @default.
- W2890131088 created "2018-09-27" @default.
- W2890131088 creator A5027730589 @default.
- W2890131088 creator A5044757404 @default.
- W2890131088 creator A5082925197 @default.
- W2890131088 date "2018-09-01" @default.
- W2890131088 modified "2023-09-26" @default.
- W2890131088 title "Report-Model studies of transmembrane interaction of FcεRIα/FcRγ reveal novel strategies to inhibit allergic responses." @default.
- W2890131088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30150199" @default.
- W2890131088 hasPublicationYear "2018" @default.
- W2890131088 type Work @default.
- W2890131088 sameAs 2890131088 @default.
- W2890131088 citedByCount "0" @default.
- W2890131088 crossrefType "journal-article" @default.
- W2890131088 hasAuthorship W2890131088A5027730589 @default.
- W2890131088 hasAuthorship W2890131088A5044757404 @default.
- W2890131088 hasAuthorship W2890131088A5082925197 @default.
- W2890131088 hasConcept C104292427 @default.
- W2890131088 hasConcept C104317684 @default.
- W2890131088 hasConcept C118892022 @default.
- W2890131088 hasConcept C153911025 @default.
- W2890131088 hasConcept C159110408 @default.
- W2890131088 hasConcept C170493617 @default.
- W2890131088 hasConcept C181199279 @default.
- W2890131088 hasConcept C185592680 @default.
- W2890131088 hasConcept C24530287 @default.
- W2890131088 hasConcept C2775880066 @default.
- W2890131088 hasConcept C2775895851 @default.
- W2890131088 hasConcept C2776414213 @default.
- W2890131088 hasConcept C2779856020 @default.
- W2890131088 hasConcept C41685203 @default.
- W2890131088 hasConcept C515207424 @default.
- W2890131088 hasConcept C55493867 @default.
- W2890131088 hasConcept C71924100 @default.
- W2890131088 hasConcept C86803240 @default.
- W2890131088 hasConcept C95444343 @default.
- W2890131088 hasConceptScore W2890131088C104292427 @default.
- W2890131088 hasConceptScore W2890131088C104317684 @default.
- W2890131088 hasConceptScore W2890131088C118892022 @default.
- W2890131088 hasConceptScore W2890131088C153911025 @default.
- W2890131088 hasConceptScore W2890131088C159110408 @default.
- W2890131088 hasConceptScore W2890131088C170493617 @default.
- W2890131088 hasConceptScore W2890131088C181199279 @default.
- W2890131088 hasConceptScore W2890131088C185592680 @default.
- W2890131088 hasConceptScore W2890131088C24530287 @default.
- W2890131088 hasConceptScore W2890131088C2775880066 @default.
- W2890131088 hasConceptScore W2890131088C2775895851 @default.
- W2890131088 hasConceptScore W2890131088C2776414213 @default.
- W2890131088 hasConceptScore W2890131088C2779856020 @default.
- W2890131088 hasConceptScore W2890131088C41685203 @default.
- W2890131088 hasConceptScore W2890131088C515207424 @default.
- W2890131088 hasConceptScore W2890131088C55493867 @default.
- W2890131088 hasConceptScore W2890131088C71924100 @default.
- W2890131088 hasConceptScore W2890131088C86803240 @default.
- W2890131088 hasConceptScore W2890131088C95444343 @default.
- W2890131088 hasIssue "5" @default.
- W2890131088 hasLocation W28901310881 @default.
- W2890131088 hasOpenAccess W2890131088 @default.
- W2890131088 hasPrimaryLocation W28901310881 @default.
- W2890131088 hasRelatedWork W1984166782 @default.
- W2890131088 hasRelatedWork W2014288004 @default.
- W2890131088 hasRelatedWork W2080181011 @default.
- W2890131088 hasRelatedWork W2150367211 @default.
- W2890131088 hasRelatedWork W2160424491 @default.
- W2890131088 hasRelatedWork W2394884746 @default.
- W2890131088 hasRelatedWork W2465101024 @default.
- W2890131088 hasRelatedWork W2527051824 @default.
- W2890131088 hasRelatedWork W4290434800 @default.
- W2890131088 hasRelatedWork W80967079 @default.
- W2890131088 hasVolume "31" @default.
- W2890131088 isParatext "false" @default.
- W2890131088 isRetracted "false" @default.
- W2890131088 magId "2890131088" @default.
- W2890131088 workType "article" @default.