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• W2890132977 abstract "Phantom limb pain (PLP) is a debilitating condition common after amputation that can considerably hinder patients’ quality of life. Several treatments have reported promising results in alleviating PLP. However, clinical evaluations are usually performed in small cohorts and rigorous clinical trials are scarce. In addition, the underlying mechanisms by which novel interventions alleviate PLP are often unclear, potentially because the condition itself is poorly understood. This article presents a theoretical framework of PLP that can be used as groundwork for hypotheses of novel treatments. Current hypotheses on the origins of PLP are discussed in relation to available clinical findings. Stochastic entanglement of the pain neurosignature, or connectome, with impaired sensorimotor circuitry is proposed as an alternative hypothesis for the genesis of PLP, and the implications and predictions this hypothesis entails are examined. In addition, I present a hypothesis for the working mechanism of Phantom Motor Execution (PME) as a treatment of PLP, along with its relation to the aforementioned stochastic entanglement hypothesis, which deals with PLP’s incipience. PME aims to reactivate the original central and peripheral circuitry involved in motor control of the missing limb, along with increasing dexterity of stump muscles. The PME hypothesis entails that training of phantom movements induces gradual neural changes similar to those of perfecting a motor skill, and these purposefully induced neural changes disentangle pain processing circuitry by competitive plasticity. This is a testable hypothesis that can be examined by brain imaging and behavioral studies on subjects undergoing PME treatment. The proposed stochastic entanglement hypothesis of PLP can be generalized to neuropathic pain due to sensorimotor impairment, and can be used to design suitable therapeutic treatments." @default.
• W2890132977 created "2018-09-27" @default.
• W2890132977 creator A5062966636 @default.
• W2890132977 date "2018-09-06" @default.
• W2890132977 modified "2023-10-18" @default.
• W2890132977 title "The Stochastic Entanglement and Phantom Motor Execution Hypotheses: A Theoretical Framework for the Origin and Treatment of Phantom Limb Pain" @default.
• W2890132977 cites W1143419823 @default.
• W2890132977 cites W1258294025 @default.
• W2890132977 cites W1508638528 @default.
• W2890132977 cites W1582611586 @default.
• W2890132977 cites W1590963585 @default.
• W2890132977 cites W1603457723 @default.
• W2890132977 cites W1782593725 @default.
• W2890132977 cites W1796735993 @default.
• W2890132977 cites W1821166321 @default.
• W2890132977 cites W1879868943 @default.
• W2890132977 cites W1923402420 @default.
• W2890132977 cites W1937787334 @default.
• W2890132977 cites W1963883925 @default.
• W2890132977 cites W1964899388 @default.
• W2890132977 cites W1966387855 @default.
• W2890132977 cites W1976933908 @default.
• W2890132977 cites W1977181697 @default.
• W2890132977 cites W1977853894 @default.
• W2890132977 cites W1979285610 @default.
• W2890132977 cites W1980165224 @default.
• W2890132977 cites W1980205873 @default.
• W2890132977 cites W1980336442 @default.
• W2890132977 cites W1980679598 @default.
• W2890132977 cites W1985120112 @default.
• W2890132977 cites W1986100203 @default.
• W2890132977 cites W1987373121 @default.
• W2890132977 cites W1992156837 @default.
• W2890132977 cites W1994217032 @default.
• W2890132977 cites W1995698477 @default.
• W2890132977 cites W1995753455 @default.
• W2890132977 cites W1997501248 @default.
• W2890132977 cites W1998057781 @default.
• W2890132977 cites W1999031782 @default.
• W2890132977 cites W2001579470 @default.
• W2890132977 cites W2005711298 @default.
• W2890132977 cites W2008812789 @default.
• W2890132977 cites W2012745722 @default.
• W2890132977 cites W2016068581 @default.
• W2890132977 cites W2018663611 @default.
• W2890132977 cites W2020870533 @default.
• W2890132977 cites W2027970772 @default.
• W2890132977 cites W2028553362 @default.
• W2890132977 cites W2028971143 @default.
• W2890132977 cites W2031832784 @default.
• W2890132977 cites W2031975075 @default.
• W2890132977 cites W2034871398 @default.
• W2890132977 cites W2035482871 @default.
• W2890132977 cites W2037667533 @default.
• W2890132977 cites W2041280124 @default.
• W2890132977 cites W2043722029 @default.
• W2890132977 cites W2044459837 @default.
• W2890132977 cites W2045120834 @default.
• W2890132977 cites W2046059817 @default.
• W2890132977 cites W2047178434 @default.
• W2890132977 cites W2048771292 @default.
• W2890132977 cites W2050316883 @default.
• W2890132977 cites W2057588442 @default.
• W2890132977 cites W2060488749 @default.
• W2890132977 cites W2069057518 @default.
• W2890132977 cites W2074380295 @default.
• W2890132977 cites W2079007789 @default.
• W2890132977 cites W2081167569 @default.
• W2890132977 cites W2084271325 @default.
• W2890132977 cites W2097700774 @default.
• W2890132977 cites W2101843765 @default.
• W2890132977 cites W2103226410 @default.
• W2890132977 cites W2104818454 @default.
• W2890132977 cites W2106163171 @default.
• W2890132977 cites W2108429804 @default.
• W2890132977 cites W2110179408 @default.
• W2890132977 cites W2111743172 @default.
• W2890132977 cites W2111790360 @default.
• W2890132977 cites W2124824246 @default.
• W2890132977 cites W2130009391 @default.
• W2890132977 cites W2131479747 @default.
• W2890132977 cites W2132309748 @default.
• W2890132977 cites W2137493947 @default.
• W2890132977 cites W2148570600 @default.
• W2890132977 cites W2150344053 @default.
• W2890132977 cites W2150441543 @default.
• W2890132977 cites W2152833623 @default.
• W2890132977 cites W2153993224 @default.
• W2890132977 cites W2154912948 @default.
• W2890132977 cites W2156830886 @default.
• W2890132977 cites W2157094999 @default.
• W2890132977 cites W2161988237 @default.
• W2890132977 cites W2169474975 @default.
• W2890132977 cites W2171456147 @default.
• W2890132977 cites W2270400488 @default.
• W2890132977 cites W2295482042 @default.
• W2890132977 cites W2328580988 @default.
• W2890132977 cites W2402033045 @default.
• W2890132977 cites W2411781414 @default.
• W2890132977 cites W2411795408 @default.

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