Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890133111> ?p ?o ?g. }
- W2890133111 endingPage "2841" @default.
- W2890133111 startingPage "2841" @default.
- W2890133111 abstract "The rate of chromosome segregation errors that emerge during meiosis I in the mammalian female germ line are known to increase with maternal age; however, little is known about the underlying molecular mechanism. The objective of this study was to analyze meiotic progression of mouse oocytes in relation to maternal age. Using the mouse as a model system, we analyzed the timing of nuclear envelope breakdown and the morphology of the nuclear lamina of oocytes obtained from young (2 months old) and aged females (12 months old). Oocytes obtained from older females display a significantly faster progression through meiosis I compared to the ones obtained from younger females. Furthermore, in oocytes from aged females, lamin A/C structures exhibit rapid phosphorylation and dissociation. Additionally, we also found an increased abundance of MPF components and increased translation of factors controlling translational activity in the oocytes of aged females. In conclusion, the elevated MPF activity observed in aged female oocytes affects precocious meiotic processes that can multifactorially contribute to chromosomal errors in meiosis I." @default.
- W2890133111 created "2018-09-27" @default.
- W2890133111 creator A5021703311 @default.
- W2890133111 creator A5024877710 @default.
- W2890133111 creator A5028951520 @default.
- W2890133111 creator A5036613537 @default.
- W2890133111 creator A5039635946 @default.
- W2890133111 creator A5041282927 @default.
- W2890133111 creator A5044324439 @default.
- W2890133111 creator A5050686192 @default.
- W2890133111 creator A5052255710 @default.
- W2890133111 creator A5069493142 @default.
- W2890133111 creator A5080257695 @default.
- W2890133111 creator A5091758668 @default.
- W2890133111 date "2018-09-19" @default.
- W2890133111 modified "2023-10-10" @default.
- W2890133111 title "Increased Expression of Maturation Promoting Factor Components Speeds Up Meiosis in Oocytes from Aged Females" @default.
- W2890133111 cites W1529934215 @default.
- W2890133111 cites W1795525374 @default.
- W2890133111 cites W1971457714 @default.
- W2890133111 cites W1974916178 @default.
- W2890133111 cites W1981093360 @default.
- W2890133111 cites W1984775769 @default.
- W2890133111 cites W1997528931 @default.
- W2890133111 cites W2018289835 @default.
- W2890133111 cites W2020520526 @default.
- W2890133111 cites W2020946972 @default.
- W2890133111 cites W2025157253 @default.
- W2890133111 cites W2038963685 @default.
- W2890133111 cites W2056032938 @default.
- W2890133111 cites W2060139430 @default.
- W2890133111 cites W2065196951 @default.
- W2890133111 cites W2065634301 @default.
- W2890133111 cites W2068843702 @default.
- W2890133111 cites W2076241697 @default.
- W2890133111 cites W2077312907 @default.
- W2890133111 cites W2079584602 @default.
- W2890133111 cites W2079921190 @default.
- W2890133111 cites W2084134136 @default.
- W2890133111 cites W2085593164 @default.
- W2890133111 cites W2092739399 @default.
- W2890133111 cites W2100246943 @default.
- W2890133111 cites W2100837269 @default.
- W2890133111 cites W2102597135 @default.
- W2890133111 cites W2105186191 @default.
- W2890133111 cites W2114435526 @default.
- W2890133111 cites W2114467586 @default.
- W2890133111 cites W2115343462 @default.
- W2890133111 cites W2123667262 @default.
- W2890133111 cites W2127394968 @default.
- W2890133111 cites W2132330478 @default.
- W2890133111 cites W2133466447 @default.
- W2890133111 cites W2146368979 @default.
- W2890133111 cites W2152752168 @default.
- W2890133111 cites W2153054542 @default.
- W2890133111 cites W2155864374 @default.
- W2890133111 cites W2157077875 @default.
- W2890133111 cites W2159808172 @default.
- W2890133111 cites W2160778315 @default.
- W2890133111 cites W2162766535 @default.
- W2890133111 cites W2163718479 @default.
- W2890133111 cites W2166516637 @default.
- W2890133111 cites W2202398807 @default.
- W2890133111 cites W2328404122 @default.
- W2890133111 cites W2430586175 @default.
- W2890133111 cites W2525306762 @default.
- W2890133111 cites W2605093440 @default.
- W2890133111 cites W2764279830 @default.
- W2890133111 cites W2765119927 @default.
- W2890133111 cites W2887504814 @default.
- W2890133111 cites W3022312892 @default.
- W2890133111 cites W590240299 @default.
- W2890133111 doi "https://doi.org/10.3390/ijms19092841" @default.
- W2890133111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6164426" @default.
- W2890133111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30235877" @default.
- W2890133111 hasPublicationYear "2018" @default.
- W2890133111 type Work @default.
- W2890133111 sameAs 2890133111 @default.
- W2890133111 citedByCount "13" @default.
- W2890133111 countsByYear W28901331112019 @default.
- W2890133111 countsByYear W28901331112020 @default.
- W2890133111 countsByYear W28901331112021 @default.
- W2890133111 countsByYear W28901331112022 @default.
- W2890133111 countsByYear W28901331112023 @default.
- W2890133111 crossrefType "journal-article" @default.
- W2890133111 hasAuthorship W2890133111A5021703311 @default.
- W2890133111 hasAuthorship W2890133111A5024877710 @default.
- W2890133111 hasAuthorship W2890133111A5028951520 @default.
- W2890133111 hasAuthorship W2890133111A5036613537 @default.
- W2890133111 hasAuthorship W2890133111A5039635946 @default.
- W2890133111 hasAuthorship W2890133111A5041282927 @default.
- W2890133111 hasAuthorship W2890133111A5044324439 @default.
- W2890133111 hasAuthorship W2890133111A5050686192 @default.
- W2890133111 hasAuthorship W2890133111A5052255710 @default.
- W2890133111 hasAuthorship W2890133111A5069493142 @default.
- W2890133111 hasAuthorship W2890133111A5080257695 @default.
- W2890133111 hasAuthorship W2890133111A5091758668 @default.
- W2890133111 hasBestOaLocation W28901331111 @default.