FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890133370> ?p ?o ?g. }

• W2890133370 abstract "Abstract Gout arthritis (GA) is a painful inflammatory disease in response to monosodium urate (MSU) crystals in the joints. 15deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ) is a natural activator of PPAR-γ with analgesic, anti-inflammatory, and pro-resolution properties. Thus, we aimed to evaluate the effect and mechanisms of action of 15d-PGJ 2 nanocapsules (NC) in the model of GA in mice, since a reduction of 33-fold in the dose of 15d-PGJ 2 has been reported. Mice were treated with 15d-PGJ 2 -loaded NC, inert NC, free 15d-PGJ 2 (without NC), or 15d-PGJ 2 -loaded NC+ GW9662, a PPAR-γ inhibitor. We show that 15d-PGJ 2 -loaded NC provided analgesic effect in a dose that the free 15d-PGJ 2 failed to inhibiting pain and inflammation. Hence, 15d-PGJ 2 -loaded NC reduced MSU-induced IL-1β, TNF-α, IL-6, IL-17, and IL-33 release and oxidative stress. Also, 15d-PGJ 2 -loaded NC decreased the maturation of IL-1β in LPS-primed BMDM triggered by MSU. Further, 15d-PGJ 2 -loaded NC decreased the expression of the components of the inflammasome Nlrp3 , Asc , and Pro-caspase-1 , as consequence of inhibiting NF-κB activation. All effects were PPAR-γ-sensitive. Therefore, we demonstrated that 15d-PGJ 2 -loaded NC present analgesic and anti-inflammatory properties in a PPAR-γ-dependent manner inhibiting IL-1β release and NF-κB activation in GA. Concluding, 15d-PGJ 2 -loaded NC ameliorates MSU-induced GA in a PPAR-γ-sensitive manner." @default.
• W2890133370 created "2018-09-27" @default.
• W2890133370 creator A5006994441 @default.
• W2890133370 creator A5017615120 @default.
• W2890133370 creator A5020393806 @default.
• W2890133370 creator A5031690868 @default.
• W2890133370 creator A5033437310 @default.
• W2890133370 creator A5035877999 @default.
• W2890133370 creator A5053616519 @default.
• W2890133370 creator A5059251523 @default.
• W2890133370 creator A5064208545 @default.
• W2890133370 creator A5072583774 @default.
• W2890133370 creator A5074382470 @default.
• W2890133370 creator A5077513818 @default.
• W2890133370 creator A5078024039 @default.
• W2890133370 creator A5078701793 @default.
• W2890133370 creator A5080486844 @default.
• W2890133370 creator A5085783926 @default.
• W2890133370 date "2018-09-18" @default.
• W2890133370 modified "2023-10-14" @default.
• W2890133370 title "15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice" @default.
• W2890133370 cites W1482159339 @default.
• W2890133370 cites W1534551308 @default.
• W2890133370 cites W1539392991 @default.
• W2890133370 cites W1565533401 @default.
• W2890133370 cites W1589636708 @default.
• W2890133370 cites W1633340712 @default.
• W2890133370 cites W1812573520 @default.
• W2890133370 cites W1890869106 @default.
• W2890133370 cites W1897205387 @default.
• W2890133370 cites W1969205037 @default.
• W2890133370 cites W1977479621 @default.
• W2890133370 cites W1979709831 @default.
• W2890133370 cites W1983393601 @default.
• W2890133370 cites W1984228225 @default.
• W2890133370 cites W1986422363 @default.
• W2890133370 cites W1986696886 @default.
• W2890133370 cites W1994659489 @default.
• W2890133370 cites W1996267589 @default.
• W2890133370 cites W1996872802 @default.
• W2890133370 cites W2002276672 @default.
• W2890133370 cites W2009800174 @default.
• W2890133370 cites W2020930525 @default.
• W2890133370 cites W2031661588 @default.
• W2890133370 cites W2034120366 @default.
• W2890133370 cites W2036047634 @default.
• W2890133370 cites W2044895791 @default.
• W2890133370 cites W2046326015 @default.
• W2890133370 cites W2051829971 @default.
• W2890133370 cites W2058894795 @default.
• W2890133370 cites W2061147690 @default.
• W2890133370 cites W2071425405 @default.
• W2890133370 cites W2077305107 @default.
• W2890133370 cites W2080034730 @default.
• W2890133370 cites W2087263689 @default.
• W2890133370 cites W2095835743 @default.
• W2890133370 cites W2095917499 @default.
• W2890133370 cites W2099297232 @default.
• W2890133370 cites W2102354025 @default.
• W2890133370 cites W2104475738 @default.
• W2890133370 cites W2115158780 @default.
• W2890133370 cites W2121053940 @default.
• W2890133370 cites W2140953825 @default.
• W2890133370 cites W2145946501 @default.
• W2890133370 cites W2149608846 @default.
• W2890133370 cites W2150359159 @default.
• W2890133370 cites W2165170037 @default.
• W2890133370 cites W2170958317 @default.
• W2890133370 cites W2258795479 @default.
• W2890133370 cites W2278476490 @default.
• W2890133370 cites W2301131921 @default.
• W2890133370 cites W2319854918 @default.
• W2890133370 cites W2334492386 @default.
• W2890133370 cites W2357676425 @default.
• W2890133370 cites W2399646749 @default.
• W2890133370 cites W2478570571 @default.
• W2890133370 cites W2507214393 @default.
• W2890133370 cites W2528762545 @default.
• W2890133370 cites W2538622696 @default.
• W2890133370 cites W2543870809 @default.
• W2890133370 cites W2551392332 @default.
• W2890133370 cites W2606973606 @default.
• W2890133370 cites W2615130940 @default.
• W2890133370 cites W2615780060 @default.
• W2890133370 cites W2626551180 @default.
• W2890133370 cites W2726607166 @default.
• W2890133370 cites W2729187549 @default.
• W2890133370 cites W2740301936 @default.
• W2890133370 cites W4248403572 @default.
• W2890133370 cites W57104003 @default.
• W2890133370 doi "https://doi.org/10.1038/s41598-018-32334-0" @default.
• W2890133370 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6143605" @default.
• W2890133370 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30228306" @default.
• W2890133370 hasPublicationYear "2018" @default.
• W2890133370 type Work @default.
• W2890133370 sameAs 2890133370 @default.
• W2890133370 citedByCount "35" @default.
• W2890133370 countsByYear W28901333702019 @default.
• W2890133370 countsByYear W28901333702020 @default.
• W2890133370 countsByYear W28901333702021 @default.

• next