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- W2890134512 abstract "Nanomaterials, such as graphene oxide (GO) are being studied to decipher their suitability in biomedical applications. This study investigate the effect on structure and function of hen egg white lysozyme (HEWL) adsorbed on GO, using various biophysical techniques. In spite of there being not much change in the structure, the catalytic activity is reduced significantly. Fluorescence quenching indicates complex formation. Fluorescence lifetime measurement suggests that GO binds at or near the active site close to Trp62 and Trp108. Heat change associated with HEWL-GO interaction suggests hydrogen bond along with van der Waals and electrostatic interactions are involved in the HEWL-GO complex. Molecular docking indicates binding of GO at the active site corroborating experimental findings. Molecular dynamics simulations indicate that the blocking of the active site affects the flexibility of the surrounding residues and contribute to the reduction of the activity. Unfolding experiments indicate that HEWL is more prone to thermal instability in presence of GO. Together, the results obtained established molecular details of HEWL-GO interaction and might be useful in eventual biomedical applications of GO." @default.
- W2890134512 created "2018-09-27" @default.
- W2890134512 creator A5000031273 @default.
- W2890134512 creator A5039886299 @default.
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- W2890134512 creator A5071816648 @default.
- W2890134512 creator A5083645854 @default.
- W2890134512 creator A5088454011 @default.
- W2890134512 date "2018-12-01" @default.
- W2890134512 modified "2023-09-24" @default.
- W2890134512 title "Molecular features of interaction involving hen egg white lysozyme immobilized on graphene oxide and the effect on activity" @default.
- W2890134512 cites W1486875326 @default.
- W2890134512 cites W1691583558 @default.
- W2890134512 cites W1886849294 @default.
- W2890134512 cites W1968024670 @default.
- W2890134512 cites W1968998311 @default.
- W2890134512 cites W1969038947 @default.
- W2890134512 cites W1969814828 @default.
- W2890134512 cites W1973831032 @default.
- W2890134512 cites W1974760003 @default.
- W2890134512 cites W1988176696 @default.
- W2890134512 cites W1991767480 @default.
- W2890134512 cites W1994136639 @default.
- W2890134512 cites W1997153101 @default.
- W2890134512 cites W1999561707 @default.
- W2890134512 cites W2004288009 @default.
- W2890134512 cites W2007215242 @default.
- W2890134512 cites W2007316257 @default.
- W2890134512 cites W2009870007 @default.
- W2890134512 cites W2021170238 @default.
- W2890134512 cites W2021229113 @default.
- W2890134512 cites W2021643078 @default.
- W2890134512 cites W2024915010 @default.
- W2890134512 cites W2029667189 @default.
- W2890134512 cites W2031970116 @default.
- W2890134512 cites W2038246612 @default.
- W2890134512 cites W2039716232 @default.
- W2890134512 cites W2047029192 @default.
- W2890134512 cites W2047404910 @default.
- W2890134512 cites W2049502419 @default.
- W2890134512 cites W2051628563 @default.
- W2890134512 cites W2053599143 @default.
- W2890134512 cites W2054668663 @default.
- W2890134512 cites W2055758194 @default.
- W2890134512 cites W2057910069 @default.
- W2890134512 cites W2084521156 @default.
- W2890134512 cites W2084613695 @default.
- W2890134512 cites W2088693256 @default.
- W2890134512 cites W2093657433 @default.
- W2890134512 cites W2094275965 @default.
- W2890134512 cites W2100241857 @default.
- W2890134512 cites W2101977779 @default.
- W2890134512 cites W2105668062 @default.
- W2890134512 cites W2106922939 @default.
- W2890134512 cites W2110470060 @default.
- W2890134512 cites W2112057811 @default.
- W2890134512 cites W2112972545 @default.
- W2890134512 cites W2117620409 @default.
- W2890134512 cites W2118233996 @default.
- W2890134512 cites W2124688926 @default.
- W2890134512 cites W2126739759 @default.
- W2890134512 cites W2128654538 @default.
- W2890134512 cites W2139549149 @default.
- W2890134512 cites W2142452135 @default.
- W2890134512 cites W2146922322 @default.
- W2890134512 cites W2147764910 @default.
- W2890134512 cites W2147993766 @default.
- W2890134512 cites W2150438401 @default.
- W2890134512 cites W2154822258 @default.
- W2890134512 cites W2158558808 @default.
- W2890134512 cites W2167029191 @default.
- W2890134512 cites W2188263579 @default.
- W2890134512 cites W2196414436 @default.
- W2890134512 cites W2239491650 @default.
- W2890134512 cites W2259189936 @default.
- W2890134512 cites W2281678963 @default.
- W2890134512 cites W2288574037 @default.
- W2890134512 cites W2325734377 @default.
- W2890134512 cites W2326517514 @default.
- W2890134512 cites W2331210993 @default.
- W2890134512 cites W2333331831 @default.
- W2890134512 cites W2398760169 @default.
- W2890134512 cites W2412672271 @default.
- W2890134512 cites W2413625270 @default.
- W2890134512 cites W2516588007 @default.
- W2890134512 cites W2534362370 @default.
- W2890134512 cites W2563721809 @default.
- W2890134512 cites W2583868006 @default.
- W2890134512 cites W2588006844 @default.
- W2890134512 cites W2590816952 @default.
- W2890134512 cites W2619775064 @default.
- W2890134512 cites W2802335867 @default.
- W2890134512 cites W378281437 @default.
- W2890134512 cites W4233194460 @default.
- W2890134512 doi "https://doi.org/10.1016/j.ijbiomac.2018.09.007" @default.
- W2890134512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30218729" @default.
- W2890134512 hasPublicationYear "2018" @default.
- W2890134512 type Work @default.