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• W2890136700 abstract "Summary The carrier state is an alternative bacteriophage life cycle by which virulent bacteriophage can persist in association with host bacteria. Campylobacter jejuni carrier state strains exhibit growth phase dependent motility due to a truncated flagella phenotype. Genome sequencing identified a T368A substitution in the G3 domain of the SRP‐like GTPase FlhF from C. jejuni PT14CP30A carrier state strains, which we hypothesized to be the cause of the complex motility phenotype. We have analyzed the role of this mutation in C. jejuni PT14 and demonstrated that flhF(T368A) leads to a large proportion of cells unable to synthesize flagella, while the remaining cells form a single flagellum at one pole leading to significantly reduced motility. The flhF(T368A) mutation causes a reduction in the phage adsorption constant, which leads to a decrease in infection efficiency. Down‐regulation of σ 28 and σ 54 dependent flagellar genes were observed as responses to the flhF(T368A) mutation. FlhF(T368A) protein is impaired in GTPase activity and exhibits reduced stability . C. jejuni carrying flhF(T368A) are less sensitive to bacteriophage infection and formation of the carrier state. The acquisition of flhF(T368A) in carrier state strains acts to prevent super‐infection and maintain association with the bacteriophage that provoked the interaction." @default.
• W2890136700 created "2018-09-27" @default.
• W2890136700 creator A5019613781 @default.
• W2890136700 creator A5086514660 @default.
• W2890136700 date "2018-10-23" @default.
• W2890136700 modified "2023-10-14" @default.
• W2890136700 title "FlhF(T368A) modulates motility in the bacteriophage carrier state of<i>Campylobacter jejuni</i>" @default.
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• W2890136700 doi "https://doi.org/10.1111/mmi.14120" @default.
• W2890136700 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6282759" @default.
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• W2890136700 hasPublicationYear "2018" @default.
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