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• W2890139175 abstract "Strictly controlled dendrite patterning underlies precise neural connection. Dendrite self-avoidance is a crucial system preventing self-crossing and clumping of dendrites. Although many cell-surface molecules that regulate self-avoidance have been identified, the signaling pathway that orchestrates it remains poorly understood, particularly in mammals. Here, we demonstrate that the LKB1-SIK kinase pathway plays a pivotal role in the self-avoidance of Purkinje cell (PC) dendrites by ensuring dendritic localization of Robo2, a regulator of self-avoidance. LKB1 is activated in developing PCs, and PC-specific deletion of LKB1 severely disrupts the self-avoidance of PC dendrites without affecting gross morphology. SIK1 and SIK2, downstream kinases of LKB1, mediate LKB1-dependent dendrite self-avoidance. Furthermore, loss of LKB1 leads to significantly decreased Robo2 levels in the dendrite but not in the cell body. Finally, restoration of dendritic Robo2 level via overexpression largely rescues the self-avoidance defect in LKB1-deficient PCs. These findings reveal an LKB1-pathway-mediated developmental program that establishes dendrite self-avoidance." @default.
• W2890139175 created "2018-09-27" @default.
• W2890139175 creator A5035479034 @default.
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• W2890139175 date "2018-09-01" @default.
• W2890139175 modified "2023-09-27" @default.
• W2890139175 title "The LKB1-SIK Pathway Controls Dendrite Self-Avoidance in Purkinje Cells" @default.
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• W2890139175 doi "https://doi.org/10.1016/j.celrep.2018.08.029" @default.
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