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• W2890139776 abstract "Post-translational modifications (PTMs), including phosphorylation, acetylation, ubiquitination, SUMOylation, etc., of proteins can modulate protein properties such as intracellular distribution, activity, stability, aggregation, and interactions. Therefore, PTMs are vital regulatory mechanisms for multiple cellular processes. Spinocerebellar ataxias (SCAs) are hereditary, heterogeneous, neurodegenerative diseases for which the primary manifestation involves ataxia. Because the pathogenesis of most SCAs is correlated with mutant proteins directly or indirectly, the PTMs of disease-related proteins might functionally affect SCA development and represent potential therapeutic interventions. Here, we review multiple PTMs related to disease-causing proteins in SCAs pathogenesis and their effects. Furthermore, we discuss these PTMs as potential targets for treating SCAs and describe translational therapies targeting PTMs that have been published." @default.
• W2890139776 created "2018-09-27" @default.
• W2890139776 creator A5019533275 @default.
• W2890139776 creator A5021555728 @default.
• W2890139776 creator A5063446960 @default.
• W2890139776 creator A5087272196 @default.
• W2890139776 creator A5088012800 @default.
• W2890139776 date "2018-09-19" @default.
• W2890139776 modified "2023-10-16" @default.
• W2890139776 title "Roles of Post-translational Modifications in Spinocerebellar Ataxias" @default.
• W2890139776 cites W1180737757 @default.
• W2890139776 cites W1483635560 @default.
• W2890139776 cites W1509995007 @default.
• W2890139776 cites W1577563769 @default.
• W2890139776 cites W1643390591 @default.
• W2890139776 cites W1844325262 @default.
• W2890139776 cites W1964232673 @default.
• W2890139776 cites W1964752963 @default.
• W2890139776 cites W1965267794 @default.
• W2890139776 cites W1965825362 @default.
• W2890139776 cites W1966816746 @default.
• W2890139776 cites W1967455040 @default.
• W2890139776 cites W1969416829 @default.
• W2890139776 cites W1971505657 @default.
• W2890139776 cites W1972792035 @default.
• W2890139776 cites W1972889041 @default.
• W2890139776 cites W1973054976 @default.
• W2890139776 cites W1974580750 @default.
• W2890139776 cites W1977381318 @default.
• W2890139776 cites W1988130372 @default.
• W2890139776 cites W1988774888 @default.
• W2890139776 cites W1990020901 @default.
• W2890139776 cites W1990115336 @default.
• W2890139776 cites W1991163497 @default.
• W2890139776 cites W1992257087 @default.
• W2890139776 cites W1992341804 @default.
• W2890139776 cites W1993287528 @default.
• W2890139776 cites W1995392239 @default.
• W2890139776 cites W1995802861 @default.
• W2890139776 cites W1998446681 @default.
• W2890139776 cites W2000048736 @default.
• W2890139776 cites W2001326517 @default.
• W2890139776 cites W2002466684 @default.
• W2890139776 cites W2004543547 @default.
• W2890139776 cites W2008526580 @default.
• W2890139776 cites W2009190820 @default.
• W2890139776 cites W2010684046 @default.
• W2890139776 cites W2012779106 @default.
• W2890139776 cites W2018185396 @default.
• W2890139776 cites W2018462246 @default.
• W2890139776 cites W2022652405 @default.
• W2890139776 cites W2023053159 @default.
• W2890139776 cites W2024171930 @default.
• W2890139776 cites W2025554299 @default.
• W2890139776 cites W2032535439 @default.
• W2890139776 cites W2036722948 @default.
• W2890139776 cites W2044984232 @default.
• W2890139776 cites W2048555293 @default.
• W2890139776 cites W2049122170 @default.
• W2890139776 cites W2049913051 @default.
• W2890139776 cites W2050971426 @default.
• W2890139776 cites W2051186583 @default.
• W2890139776 cites W2052404695 @default.
• W2890139776 cites W2052422567 @default.
• W2890139776 cites W2052883021 @default.
• W2890139776 cites W2057688655 @default.
• W2890139776 cites W2060168110 @default.
• W2890139776 cites W2060402656 @default.
• W2890139776 cites W2062468836 @default.
• W2890139776 cites W2066264051 @default.
• W2890139776 cites W2066582788 @default.
• W2890139776 cites W2068806054 @default.
• W2890139776 cites W2069113259 @default.
• W2890139776 cites W2070963496 @default.
• W2890139776 cites W2075341764 @default.
• W2890139776 cites W2076446466 @default.
• W2890139776 cites W2076627447 @default.
• W2890139776 cites W2077292361 @default.
• W2890139776 cites W2077356655 @default.
• W2890139776 cites W2079795628 @default.
• W2890139776 cites W2079813087 @default.
• W2890139776 cites W2083134947 @default.
• W2890139776 cites W2085905822 @default.
• W2890139776 cites W2093520089 @default.
• W2890139776 cites W2094898650 @default.
• W2890139776 cites W2097704427 @default.
• W2890139776 cites W2099821270 @default.
• W2890139776 cites W2105954114 @default.
• W2890139776 cites W2114200723 @default.
• W2890139776 cites W2116015530 @default.
• W2890139776 cites W2117120482 @default.
• W2890139776 cites W2120715236 @default.
• W2890139776 cites W2121568850 @default.
• W2890139776 cites W2123292231 @default.
• W2890139776 cites W2123347941 @default.
• W2890139776 cites W2123588104 @default.
• W2890139776 cites W2125774668 @default.
• W2890139776 cites W2130679131 @default.
• W2890139776 cites W2131575598 @default.
• W2890139776 cites W2131898220 @default.

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