Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890139810> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2890139810 abstract "Myopia, as a common ocular disorder, is caused by both genetic and environmental factors. Conventional genome-wide association studies (GWAS) in humans have limited power to detect myopia genes partly due to the complex interplay between genes and environment. Here, I performed a GWAS in a sample of chicks with form deprivation (FD) myopia, aiming to reduce environmental complexity and increase the statistical power to detect genetic variants that confer susceptibility to this environmentally-induced myopia phenotype.The degree of FD myopia was quantified by measuring the treatment-induced changes in axial length (∆AXL) and mean spherical equivalent (∆MSE). Body weight, sex, and batch were evaluated as potential confounding factors. To reduce costs, chicks in the phenotype extremes (lowest or highest ∆AXL, within each batch) were selected for genotyping.To identify genetic variants conferring susceptibility to myopia, GWA analyses for ∆AXL and ∆MSE were applied to the genotype data. After adjusting for confounding factors, genetic variant rs317386235, located between the genes PRKAR2B and PIK3CG exceeded the Bonferroni corrected significance threshold for ∆AXL. To complement the GWAS findings, an RNA sequencing transcriptomics analysis was performed, using retinal tissue from the treated and control eyes of chicks with high or low-susceptibility to myopia. This revealed 516 differentially-expressed genes, identified using a combination of three analysis tools. In order to discover more about the biological function underlying the GWAS and transcriptomics analysis results, pathway analyses were conducted. The pathway analysis implicated gene sets relating to circadian rhythms, extracellular matrix (ECM) and structural remodelling, energy generation, oxidative stress, glycometabolism and lipid metabolism." @default.
- W2890139810 created "2018-09-27" @default.
- W2890139810 creator A5084076285 @default.
- W2890139810 date "2018-05-14" @default.
- W2890139810 modified "2023-09-27" @default.
- W2890139810 title "Gene-environment interactions in myopia" @default.
- W2890139810 hasPublicationYear "2018" @default.
- W2890139810 type Work @default.
- W2890139810 sameAs 2890139810 @default.
- W2890139810 citedByCount "0" @default.
- W2890139810 crossrefType "dissertation" @default.
- W2890139810 hasAuthorship W2890139810A5084076285 @default.
- W2890139810 hasConcept C104317684 @default.
- W2890139810 hasConcept C106208931 @default.
- W2890139810 hasConcept C126322002 @default.
- W2890139810 hasConcept C127716648 @default.
- W2890139810 hasConcept C135763542 @default.
- W2890139810 hasConcept C150194340 @default.
- W2890139810 hasConcept C153209595 @default.
- W2890139810 hasConcept C162317418 @default.
- W2890139810 hasConcept C186413461 @default.
- W2890139810 hasConcept C31467283 @default.
- W2890139810 hasConcept C54355233 @default.
- W2890139810 hasConcept C69991583 @default.
- W2890139810 hasConcept C70721500 @default.
- W2890139810 hasConcept C71924100 @default.
- W2890139810 hasConcept C77350462 @default.
- W2890139810 hasConcept C86803240 @default.
- W2890139810 hasConceptScore W2890139810C104317684 @default.
- W2890139810 hasConceptScore W2890139810C106208931 @default.
- W2890139810 hasConceptScore W2890139810C126322002 @default.
- W2890139810 hasConceptScore W2890139810C127716648 @default.
- W2890139810 hasConceptScore W2890139810C135763542 @default.
- W2890139810 hasConceptScore W2890139810C150194340 @default.
- W2890139810 hasConceptScore W2890139810C153209595 @default.
- W2890139810 hasConceptScore W2890139810C162317418 @default.
- W2890139810 hasConceptScore W2890139810C186413461 @default.
- W2890139810 hasConceptScore W2890139810C31467283 @default.
- W2890139810 hasConceptScore W2890139810C54355233 @default.
- W2890139810 hasConceptScore W2890139810C69991583 @default.
- W2890139810 hasConceptScore W2890139810C70721500 @default.
- W2890139810 hasConceptScore W2890139810C71924100 @default.
- W2890139810 hasConceptScore W2890139810C77350462 @default.
- W2890139810 hasConceptScore W2890139810C86803240 @default.
- W2890139810 hasLocation W28901398101 @default.
- W2890139810 hasOpenAccess W2890139810 @default.
- W2890139810 hasPrimaryLocation W28901398101 @default.
- W2890139810 hasRelatedWork W1496855348 @default.
- W2890139810 hasRelatedWork W2517347321 @default.
- W2890139810 hasRelatedWork W2591470648 @default.
- W2890139810 hasRelatedWork W2789880132 @default.
- W2890139810 hasRelatedWork W2792922085 @default.
- W2890139810 hasRelatedWork W2794376599 @default.
- W2890139810 hasRelatedWork W2887240983 @default.
- W2890139810 hasRelatedWork W2891986494 @default.
- W2890139810 hasRelatedWork W2922619836 @default.
- W2890139810 hasRelatedWork W2965038419 @default.
- W2890139810 hasRelatedWork W2966688979 @default.
- W2890139810 hasRelatedWork W2968794964 @default.
- W2890139810 hasRelatedWork W2972164954 @default.
- W2890139810 hasRelatedWork W3003389941 @default.
- W2890139810 hasRelatedWork W3012997316 @default.
- W2890139810 hasRelatedWork W3025047014 @default.
- W2890139810 hasRelatedWork W3044634089 @default.
- W2890139810 hasRelatedWork W3102035843 @default.
- W2890139810 hasRelatedWork W3180822706 @default.
- W2890139810 hasRelatedWork W3186993530 @default.
- W2890139810 isParatext "false" @default.
- W2890139810 isRetracted "false" @default.
- W2890139810 magId "2890139810" @default.
- W2890139810 workType "dissertation" @default.