FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2890139938> ?p ?o ?g. }

• W2890139938 endingPage "10" @default.
• W2890139938 startingPage "1" @default.
• W2890139938 abstract "ARG1, which encodes Arginase1, is expressed in the liver cytoplasm and plays a major role in the hepatic urea cycle. The past research works shed light on the fact that ARG1 participates in anti-inflammation, tumor immunity, and immunosuppression-related diseases. Nevertheless, the concrete role and clinical significance of ARG1 in the progression of hepatocellular carcinoma (HCC) remain unclear. Herein, we aimed at examining the expression and clinicopathological significance of ARG1 in HCC, together with determining the effect of ARG1 on the progression and metastasis of HCC. In the current study, evaluation of the expression of ARG1 and clinicopathological significance of ARG1 was carried out in the human HCC tissues microarray, and the ARG1 overexpression vector and shRNA-ARG1 plasmids were constructed for the assessment of the concrete effect of ARG1 on cellular behaviors of Huh7 cells. As our data revealed, ARG1 was significantly downregulated in HCC, and the higher expression of ARG1 was positively correlated with more aggressive tumor growth, size, ALT, and GGT level. Significantly, we found that the high expression of ARG1 was correlated with poor DFS of HCC patients. Besides, in vitro study revealed that overexpression of ARG1 could enhance arginase activity, cell viability, migration, and invasion of Huh7 cells, and loss-of-function of ARG1 by shRNA interference could inhibit these cellular behaviors. Additionally, overexpression of ARG1 led to a significant increase in the expression of Vimentin, N-cadherin, and β -catenin both at protein and mRNA levels, which promotes the EMT process. On the other hand, these proteins' expression was significantly downregulated in ARG1 silenced Huh7 cells. Besides, the level of E-cadherin protein was upregulated in ARG1 knocked down cells. In conclusion, ARG1 might play a pivotal role as an oncogene in the progression of HCC through promoting the EMT process." @default.
• W2890139938 created "2018-09-27" @default.
• W2890139938 creator A5039482364 @default.
• W2890139938 creator A5041451993 @default.
• W2890139938 creator A5048379858 @default.
• W2890139938 creator A5050439687 @default.
• W2890139938 creator A5063646416 @default.
• W2890139938 creator A5079873709 @default.
• W2890139938 date "2018-09-18" @default.
• W2890139938 modified "2023-10-16" @default.
• W2890139938 title "The Oncogenic Role of ARG1 in Progression and Metastasis of Hepatocellular Carcinoma" @default.
• W2890139938 cites W1581040284 @default.
• W2890139938 cites W1757407923 @default.
• W2890139938 cites W1942579167 @default.
• W2890139938 cites W1960350516 @default.
• W2890139938 cites W1973582816 @default.
• W2890139938 cites W1977179270 @default.
• W2890139938 cites W2010257788 @default.
• W2890139938 cites W2046056065 @default.
• W2890139938 cites W2050441306 @default.
• W2890139938 cites W2077023434 @default.
• W2890139938 cites W2084310440 @default.
• W2890139938 cites W2090747780 @default.
• W2890139938 cites W2097642044 @default.
• W2890139938 cites W2106027870 @default.
• W2890139938 cites W2107450322 @default.
• W2890139938 cites W2109017823 @default.
• W2890139938 cites W2116554142 @default.
• W2890139938 cites W2117692326 @default.
• W2890139938 cites W2123105952 @default.
• W2890139938 cites W2128693062 @default.
• W2890139938 cites W2168761753 @default.
• W2890139938 cites W2353056405 @default.
• W2890139938 cites W2417139284 @default.
• W2890139938 cites W2586263334 @default.
• W2890139938 cites W2605768453 @default.
• W2890139938 cites W2622374255 @default.
• W2890139938 cites W2774484554 @default.
• W2890139938 cites W2802759810 @default.
• W2890139938 cites W4242460909 @default.
• W2890139938 cites W4362218836 @default.
• W2890139938 doi "https://doi.org/10.1155/2018/2109865" @default.
• W2890139938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6167590" @default.
• W2890139938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30320132" @default.
• W2890139938 hasPublicationYear "2018" @default.
• W2890139938 type Work @default.
• W2890139938 sameAs 2890139938 @default.
• W2890139938 citedByCount "47" @default.
• W2890139938 countsByYear W28901399382019 @default.
• W2890139938 countsByYear W28901399382020 @default.
• W2890139938 countsByYear W28901399382021 @default.
• W2890139938 countsByYear W28901399382022 @default.
• W2890139938 countsByYear W28901399382023 @default.
• W2890139938 crossrefType "journal-article" @default.
• W2890139938 hasAuthorship W2890139938A5039482364 @default.
• W2890139938 hasAuthorship W2890139938A5041451993 @default.
• W2890139938 hasAuthorship W2890139938A5048379858 @default.
• W2890139938 hasAuthorship W2890139938A5050439687 @default.
• W2890139938 hasAuthorship W2890139938A5063646416 @default.
• W2890139938 hasAuthorship W2890139938A5079873709 @default.
• W2890139938 hasBestOaLocation W28901399381 @default.
• W2890139938 hasConcept C104317684 @default.
• W2890139938 hasConcept C121608353 @default.
• W2890139938 hasConcept C147447768 @default.
• W2890139938 hasConcept C166703698 @default.
• W2890139938 hasConcept C173396325 @default.
• W2890139938 hasConcept C190232843 @default.
• W2890139938 hasConcept C203014093 @default.
• W2890139938 hasConcept C204232928 @default.
• W2890139938 hasConcept C2778019345 @default.
• W2890139938 hasConcept C2779013556 @default.
• W2890139938 hasConcept C502942594 @default.
• W2890139938 hasConcept C54355233 @default.
• W2890139938 hasConcept C55493867 @default.
• W2890139938 hasConcept C555283112 @default.
• W2890139938 hasConcept C67705224 @default.
• W2890139938 hasConcept C81885089 @default.
• W2890139938 hasConcept C86803240 @default.
• W2890139938 hasConceptScore W2890139938C104317684 @default.
• W2890139938 hasConceptScore W2890139938C121608353 @default.
• W2890139938 hasConceptScore W2890139938C147447768 @default.
• W2890139938 hasConceptScore W2890139938C166703698 @default.
• W2890139938 hasConceptScore W2890139938C173396325 @default.
• W2890139938 hasConceptScore W2890139938C190232843 @default.
• W2890139938 hasConceptScore W2890139938C203014093 @default.
• W2890139938 hasConceptScore W2890139938C204232928 @default.
• W2890139938 hasConceptScore W2890139938C2778019345 @default.
• W2890139938 hasConceptScore W2890139938C2779013556 @default.
• W2890139938 hasConceptScore W2890139938C502942594 @default.
• W2890139938 hasConceptScore W2890139938C54355233 @default.
• W2890139938 hasConceptScore W2890139938C55493867 @default.
• W2890139938 hasConceptScore W2890139938C555283112 @default.
• W2890139938 hasConceptScore W2890139938C67705224 @default.
• W2890139938 hasConceptScore W2890139938C81885089 @default.
• W2890139938 hasConceptScore W2890139938C86803240 @default.
• W2890139938 hasFunder F4320321878 @default.
• W2890139938 hasLocation W28901399381 @default.
• W2890139938 hasLocation W28901399382 @default.

• next